Abstract:
:Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoof-horn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship with pro-inflammatory cytokine (IL-1β) and virulent Dichelobacter nodosus in footrot. From 55 healthy and 30 footrot ovine feet, parallel biopsies (one fixed for histology) were collected post-slaughter and analysed for lesions and histopathological analysis using haematoxylin and eosin and Periodic Acid-Schiff. Histological lesions were similar in both conditions while inflammatory scores mirror IL-1β expression levels. Increased inflammatory score corresponded with high virulent D. nodosus load and was significant (p < 0.0001) in footrot feet with an inflammatory score of 3 compared to scores 1 and 2. In addition, in contrast to healthy tissues, localisation of eubacterial load extended beyond follicular depths in footrot samples. The novel inflammatory cell infiltration scoring system in this study may be used to grade inflammatory response in the ovine feet and demonstrated an association between severity of inflammatory response and increased virulent D. nodosus load.
journal_name
PeerJjournal_title
PeerJauthors
Agbaje M,Rutland CS,Maboni G,Blanchard A,Bexon M,Stewart C,Jones MA,Totemeyer Sdoi
10.7717/peerj.5097subject
Has Abstractpub_date
2018-07-02 00:00:00pages
e5097issn
2167-8359pii
5097journal_volume
6pub_type
杂志文章相关文献
PeerJ文献大全abstract::Genome sequencing is rapidly being adopted in reference labs and hospitals for bacterial outbreak investigation and diagnostics where time is critical. Seven gene multi-locus sequence typing is a standard tool for broadly classifying samples into sequence types (STs), allowing, in many cases, to rule a sample out of a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5233
更新日期:2018-07-31 00:00:00
abstract::As a vector of Xylella fastidiosa (Wells, 1987) in Europe, the meadow spittlebug Philaenus spumarius (Linnaeus, 1758) (Hemiptera, Aphrophoridae) is a species of major concern. Therefore, tools and agents to control this ubiquitous insect that develops and feeds on hundreds of plant species are wanted. We conducted a f...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8591
更新日期:2020-03-24 00:00:00
abstract::Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5908
更新日期:2018-11-30 00:00:00
abstract::Background. Quotations and references are an indispensable element of scientific communication. They should support what authors claim or provide important background information for readers. Studies indicate, however, that quotations not serving their purpose-quotation errors-may be prevalent. Methods. We carried out...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1364
更新日期:2015-10-27 00:00:00
abstract::The massive influx of pelagic Sargassum spp. (sargasso) into the Mexican Caribbean Sea has caused major deterioration of the coastal environment and has affected the tourism industry as well as livelihoods since 2015. Species of Sargassum have high capacity to absorb metals; thus, leachates of sargasso may contribute ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8667
更新日期:2020-02-26 00:00:00
abstract::Neurons are embedded in an extracellular matrix (ECM), which functions both as a scaffold and as a regulator of neuronal function. The ECM is in turn dynamically altered through the action of serine proteases, which break down its constituents. This pathway has been implicated in the regulation of synaptic plasticity ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6796
更新日期:2019-04-23 00:00:00
abstract:Background:Geographic variation in body size and condition can reveal differential local adaptation to resource availability or climatic factors. Body size and condition are related to fitness in garter snakes (Thamnophis), thus good body condition may increase survival, fecundity in females, and mating success in male...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6601
更新日期:2019-03-13 00:00:00
abstract::Seymouria is the best known of the seymouriamorphs, a group of Permo-Carboniferous reptiliomorphs with both terrestrial and aquatic taxa. The majority of research on Seymouria has focused on cranial anatomy, with few detailed descriptions or illustrations of the postcrania. We utilized neutron computed tomography (nCT...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8698
更新日期:2020-03-10 00:00:00
abstract::Ocean acidification (OA) is one of the most significant threats to marine life, and is predicted to drive important changes in marine communities. Although OA impacts will be the sum of direct effects mediated by alterations of physiological rates and indirect effects mediated by shifts in species interactions and bio...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5327
更新日期:2018-07-31 00:00:00
abstract::Construction of hydropower stations has been an important approach to meet China's increasing power demand, but the impact of construction of hydropower stations on river microbiota is not fully understood. To evaluate this, the microbial composition from 18 sampling sites in the downstream of Jinsha River of China, u...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9500
更新日期:2020-07-16 00:00:00
abstract::Heterodonty in Crocodylia and closely related taxa has not been defined quantitatively, as the teeth rarely have been measured. This has resulted in a range of qualitative descriptors, with little consensus on the condition of dental morphology in the clade. The purpose of this study is to present a method for the qua...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6485
更新日期:2019-02-28 00:00:00
abstract::Anemones of genus Exaiptasia are used as model organisms for the study of cnidarian-dinoflagellate (genus Symbiodinium) endosymbiosis. However, while most reef-building corals harbor Symbiodinium of clade C, Exaiptasia spp. anemones mainly harbor clade B Symbiodinium (ITS2 type B1) populations. In this study, we revea...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2358
更新日期:2016-08-24 00:00:00
abstract:Background:Conserving both biodiversity and ecosystem services is a major goal of the Convention on Biological Diversity. Hotspots for biodiversity in the Andes significantly overlap with areas with dense human populations that sustain their economy through agricultural production. Therefore, developing management form...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6207
更新日期:2019-02-13 00:00:00
abstract::Osteosarcoma is a common malignancy seen mainly in children and adolescents. The disease is characterized by poor overall prognosis and lower survival due to a lack of predictive markers. Many gene signatures with diagnostic, prognostic, and predictive values were evaluated to achieve better clinical outcomes. Two pub...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10633
更新日期:2021-01-15 00:00:00
abstract:Background:Stellera chamaejasme Linn, an important poisonous plant of the China grassland, is toxic to humans and livestock. The rapid expansion of S. chamaejasme has greatly damaged the grassland ecology and, consequently, seriously endangered the development of animal husbandry. To draft efficient prevention and cont...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4535
更新日期:2018-04-03 00:00:00
abstract::Recent improvements in next-generation sequencing (NGS) technologies can facilitate the obtainment of mitochondrial genomes. However, it is not clear whether NGS could be effectively used to reconstruct the mitogenome with high gene rearrangement. These high rearrangements would cause amplification failure, and/or ass...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2786
更新日期:2016-12-15 00:00:00
abstract::In highly biodiverse systems, such as coral reefs, prey species are faced with predatory threats from numerous species. Recognition of predators can be innate, or learned, and can help increase the chance of survival. Research suggests that parental exposure to increased predatory threats can affect the development, b...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9340
更新日期:2020-06-18 00:00:00
abstract::We provided chimpanzees (Pan troglodytes) with the ability to improve the quality of food rewards they received in a dyadic test of inequity. We were interested to see if this provision influenced their responses and, if so, whether it was mediated by a social partner's outcomes. We tested eight dyads using an exchang...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.165
更新日期:2013-09-17 00:00:00
abstract:Background:Adnexal torsion is a gynecologic emergency that requires surgical treatment. In this study, we reviewed the surgical outcomes of women with adnexal torsion in eastern Taiwan (Hualien county, area 4,629 km2, 330,000 residents). Methods:This retrospective study included 42 women diagnosed with surgically-prov...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5995
更新日期:2018-12-04 00:00:00
abstract::The Asian clam, Corbicula fluminea, is a commonly consumed small freshwater bivalve in East Asia. However, available genetic information of this clam is still limited. In this study, the transcriptome of female C. fluminea was sequenced using the Illumina HiSeq 2500 platform. A total of 89,563 unigenes were assembled ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7770
更新日期:2019-10-22 00:00:00
abstract:Background:The body of literature regarding the associations between physical activity and psychological problems lacks consensus. Moreover, the role of gender has been scarcely investigated. The present study sought to fill the gap in the data by examining the associations, if any, between moderate-to-vigorous physica...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8775
更新日期:2020-03-25 00:00:00
abstract:Background:Although the postural instability accompanying bilateral vestibular loss in human and quadrupeds during lateral head movements are well-known, it is still unclear whether or not lateral head turns would indeed activate the postural control system to maintain balance. This study aimed to examine the kinetic p...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8186
更新日期:2019-12-12 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effects of age, body condition score (BCS) and muscle condition score (MCS) on indirect radial and coccygeal Doppler systolic arterial blood pressure (SAP) measurements in dogs. METHODS:Sixty-two privately-owned dogs were enrolled between June and July 2016. The BC...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3101
更新日期:2017-03-22 00:00:00
abstract::Ocean acidification (OA) is not an isolated threat, but acts in concert with other impacts on ecosystems and species. Coastal marine invertebrates will have to face the synergistic interactions of OA with other global and local stressors. One local factor, common in coastal environments, is trace element contamination...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.538
更新日期:2014-09-09 00:00:00
abstract::Previous studies of population genetic structure in Dissostichus eleginoides have shown that oceanographic and geographic discontinuities drive in this species population differentiation. Studies have focused on the genetics of D. eleginoides in the Southern Ocean; however, there is little knowledge of their genetic v...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4173
更新日期:2018-01-16 00:00:00
abstract::The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy in clinical trials, and several studies provide promising combination strategies to substantially maximize therapeu...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5092
更新日期:2018-06-19 00:00:00
abstract::Elucidating the molecular mechanism of helix-coil transitions of short peptides is a long-standing conundrum in physical chemistry. Although the helix-coil transitions of poly-glutamic acid (PGA) have been extensively studied, the molecular details of its unfolding process still remain unclear. We performed all-atom c...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4769
更新日期:2018-05-15 00:00:00
abstract:Background:Extensive genome rearrangements, known as chromothripsis, have been recently identified in several cancer types. Chromothripsis leads to complex structural variants (cSVs) causing aberrant gene expression and the formation of de novo fusion genes, which can trigger cancer development, or worsen its clinical ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7071
更新日期:2019-06-12 00:00:00
abstract::There is a lack of stability in language difficulties across early childhood: most late talkers (LTs) resolve their difficulties by pre-school; and a significant number of children who were not LTs subsequently manifest language difficulties. Greater reliability in predicting individual outcomes is needed, which might...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1098
更新日期:2015-07-23 00:00:00
abstract::Rhynchosauria is a group of archosauromorph reptiles abundant in terrestrial ecosystems of the Middle Triassic. Mesosuchus is one of the earliest and basalmost rhynchosaurs, playing an important role not only for the understanding of the evolution of the group as a whole, but also of archosauromorphs in general. The b...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6798
更新日期:2019-05-22 00:00:00