Abstract：
PURPOSE:Molecular basis of various forms of hyperinsulinemic hypoglycemia, involving defects in key genes regulating insulin secretion, are being increasingly reported. However, the management of medically unresponsive hyperinsulinism still remains a challenge as current facilities for genetic diagnosis and appropriate imaging are limited only to very few centers in the world. We aim to provide an overview of spectrum of clinical presentation, diagnosis and management of hyperinsulinism. METHODS:We searched the Cochrane library, MEDLINE and EMBASE databases, and reference lists of identified studies. CONCLUSION:Analysis of blood samples, collected at the time of hypoglycemic episodes, for intermediary metabolites and hormones is critical for diagnosis and treatment. Increased awareness among clinicians about infants at-risk of hypoglycemia, and recent advances in genetic diagnosis have made remarkable contribution to the diagnosis and management of hyperinsulinism. Newer drugs like lanreotide a long acting somatostatin analogue and sirolimus (mammalian target of rapamycin (mTOR) inhibitor) appears promising as patients with diffuse disease can be treated successfully without subtotal pancreatectomy, minimizing the long-term sequelae of diabetes and pancreatic insufficiency. Newer insights in understanding the molecular and histological basis and improvements in imaging and surgical techniques will modify the approach to patients with congenital hyperinsulinism.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Vora S,Chandran S,Rajadurai VS,Hussain Kdoi
10.1007/s13312-015-0772-1subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1051-9issue
12eissn
0019-6061issn
0974-7559journal_volume
52pub_type
杂志文章,评审abstract：:Pediatric coronavirus disease-19 (COVID-19) infection is relatively mild when compared to adults, and children are reported to have a better prognosis. Mortality in children appears rare. Clinical features of COVID-19 in children include fever and cough, but a large proportion of infected children appears to be asympt...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：2020-05-15 00:00:00
abstract：OBJECTIVE:To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis. METHODS:Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocyt...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-014-0470-4
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy of artemether and quinine in the treatment of severe malaria in hospitalized children. STUDY DESIGN:Open randomized trial. SETTING:Pediatric ward of a tertiary care center. METHODS:All children admitted with clinical manifestations of severe malaria (as per WHO criteria) and asexual...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-10-01 00:00:00
abstract：:A quadrivalent MMRV (measles-mumps-rubella-varicella) combination vaccine has recently been launched in India. This vaccine is highly immunogenic, with seroconversion rates against all antigens reaching 96.6-100% at 42 to 56 days after the second vaccine dose in unvaccinated children or in those previously vaccinated ...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-017-1209-9
更新日期：2017-12-15 00:00:00
abstract：OBJECTIVE:To assess the efficacy of nasal intermittent positive pressure ventilation with heliox in preterm infants with respiratory distress syndrome. METHODS:Premature infants with mild respiratory distress syndrome requiring non-invasive respiratory support were eligible. Infants were randomly assigned to heliox or...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13312-014-0524-7
更新日期：2014-11-01 00:00:00
abstract：:There is a large child work force in India reported to be about 40 million. Child labor is being regarded as a form of modern slavery, as children are forced to work or have no choice to refuse work. Children are employed in a variety of occupations, many of which are hazardous. Exposure to machinery, pesticides, dust...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-08-15 00:00:00
abstract：:Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare genetic disorder characterized by lipoatrophy, hypertriglyceridemia, hepatomegaly and acromegaloid features. On the basis of mutational and haplotype analysis, BSCL families have been classified into three types BSCL 1, BSCL2 and BSCLX. We report Berardi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of a community oral health awareness program given to mothers through trained community level workers (Junior Public Health Nurses (JPHNs) and Anganwadi workers (AWWs). METHODS:Oral health education materials were prepared based on the findings of a knowledge survey among commun...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:In the present study, brainstorm auditory evoked responses (BAER) were recorded in 68 at risk neonates discharged from the neonatal ICU of Safdarjung Hospital. The high risk group of 35 neonates included 13 neonates with multiple (3-4) risk factors and 22 neonates with single risk factors, viz., prematurity (less than...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The retrospective study was carried out to examine performance of Pottels height- independent equation compared to Schwartzs height-dependent equation to estimate glomerular filtration rate in 115 children in Indian setting. The Pottels equation performed well compared to updated Schwartz equation (R2=0.94, mean bias ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-017-1001-x
更新日期：2017-01-15 00:00:00
abstract：:To identify an inexpensive, reliable predictor of low birth weight capable of being utilized by untrained personnel, anthropometric measures were performed on 1600 newborns in Kanpur, India. This analysis indicated that, for a birth weight of 2500 g, the critical limit of calf circumference was 10.8 cm or less. Crit...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Twenty children of acute viral hepatitis were subjected to ultrasound of gall bladder in acute and recovery phase. Increased wall thickness, reduced volume and abnormal echo-texture of gall bladder contents were the findings in the acute phase. A normal ultrasound of gall bladder was restored in most of the patients w...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Postictal values of plasma prolactin levels were measured in 15 children with generalized seizures, 8 children with pseudoseizures and 6 control subjects. In patients with generalized seizure, the mean plasma prolactin level was 28.6 +/- 2.3 ng/ml, whereas in patients with pseudoseizures and in controls, its mean valu...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug among febrile children. DESIGN:Randomized controlled trial. SETTING:Tertiary care hospital. PARTICIPANTS:150 children 6 mo - 12 yr age with axillary temperature 101F. INTERVENTION:Tepid sponging and antipyreti...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To evaluate endothelial function and arterial mechanics in apparently healthy overweight adolescents. DESIGN:Analytical observational study. SETTING:Tertiary hospital. METHODS:40 asymptomatic, normotensive and non-smoking adolescents (11 to 18 years old) were evaluated. Of these 20 were overweight or obese...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Salmonella senftenberg was isolated from the stools of 35 newborns between June, 1987 and September, 1988. Twenty nine (82.8%) babies were preterms and twenty six (74%) babies were less than 2,000 grams in weight. All of them were symptomatic within 6 days of life, 74.3% (26) within 4 days. All of them had loose stool...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:Management of pyothorax and pneumothorax requires aspiration and/or intercostal drainage. CASE CHARACTERISTICS:We present two cases which were complicated by instrument-related events resulting in breakage of needle or intercostal drainage tube resulting in pleural foreign body. INTERVENTION/OUTCOME:The pa...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0848-6
更新日期：2016-04-01 00:00:00
abstract：:Highly active antiretroviral therapy is beyond reach of most HIV-infected children in developing countries. There is paucity of data on more affordable regimens such as ones based on nevirapine and 2 nucleoside reverse transcriptase inhibitors. We report our experience with the use of antiretroviral therapy in childre...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:Thirty-two infants above one month of age admitted to a tertiary care hospital with signs of infection and presumptive diagnosis of sepsis were included. Cytokine levels of tumor necrosis factor alpha (TNFmu) and interleukin-6 (IL 6) were estimated at admission and after 48 to 72 hr, and their relationship examined to...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:Thirty six neonates with severe birth asphyxia (Apgar score less than or equal to 3 at 1 min), 32 with moderate birth asphyxia (Apgar score 4 to 6 at 1 min) and 35 controls (Apgar score greater than or equal to 7 at 1 min) matched for weight and gestation were followed up prospectively for neurodevelopmental outcome. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Increasing availability of DNA based tests in clinical practice has lead to widespread debate on the ethical issues involved. The wider usage of these tests in children has raised many questions regarding the ethics, validity of the request and its effects on childs psychosocial well-being. Though there have been much...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0228-4
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To compare lipid parameters between diabetics and controls and to study association between metabolic control and lipid profile. METHODS:Lipid profile and HbA1c were measured (n=80, 39 boys) in diabetic children [age 10.7(3.4) y] and 54 controls, tests repeated after 1 year (in 45 diabetics). RESULTS:Diabet...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0787-2
更新日期：2016-01-01 00:00:00
abstract：: ...
journal_title：Indian pediatrics
pub_type： 信件
doi：
更新日期：2019-02-15 00:00:00
abstract：:In 2009, India contributed to over half the global cases of poliomyelitis. Many believed that India would be the last country to be polio free. India proved them wrong and was certified polio free in 2014. In January 2016, India celebrated 5 years of being polio free. One of the major reasons behind the interruption o...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：2016-08-07 00:00:00
abstract：:We report on 16 children with ingestion of magnetic foreign bodies, who were identified by a medical record review of our hospital data for the time period between January, 2017 and May, 2018. Digestive tract wall was sandwiched in 13 (75%) children and 11 (74%) had gaptic intestinal perforation. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-06-24 00:00:00
abstract：BACKGROUND:E-type prostaglandins (PGE1) can effectively maintain the patency of the ductus arteriosus in neonates. Its use, therefore and be life saving in infants born with ductus dependent congenital heart disease. Although PGE1 is available for over two decade in western world, it has been introduced in India only s...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:The study aimed to explore the perception and knowledge-gain of undergraduate medical students during the Medical Council of India-mandated one month foundation course in August, 2019. A total of 129 consenting students who underwent the foundation course were enrolled and their feedback collected using an email-based...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-03-15 00:00:00
abstract：OBJECTIVE:To evaluate simple clinical signs of illness in young infants (0 to 2 months) and to correlate with WHO IMCI algorithm (7 days-2 months). DESIGN:Prospective observational. Study conducted in the outpatient department and emergency room of a pediatric tertiary level hospital. METHODS:Four hundred and ninety ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：JUSTIFICATION:Gaucher disease (GD) is amongst the most frequently occurring lysosomal storage disorder in all ethnicities. The clinical manifestations and natural history of GD is highly heterogeneous with extreme geographic and ethnic variations. The literature on GD has paucity of information and optimal management g...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-02-15 00:00:00
abstract：:Audit in medicine is a well tried means of assessing the quality of practice by using acceptable measures of outcome. Audit in maternal and child health has been limited to fatal outcomes such as maternal and perinatal deaths. The outcome of audit is of interest to the providers, the health authorities and the consume...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
