Coronavirus Disease 2019 (COVID-19) in Children - What We Know So Far and What We Do Not.

Abstract:

:Pediatric coronavirus disease-19 (COVID-19) infection is relatively mild when compared to adults, and children are reported to have a better prognosis. Mortality in children appears rare. Clinical features of COVID-19 in children include fever and cough, but a large proportion of infected children appears to be asymptomatic and may contribute to transmission. It remains unclear why children and young adults are less severely affected than older individuals, but this might involve differences in immune system function in the elderly and/or differences in the expression/function of the cellular receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)- Angiotensin converting enzyme 2 (ACE2). Laboratory findings and chest imaging may not be specific in children with COVID-19. Diagnosis is by Reverse transcriptase-Polymerase chain reaction (RT-PCR) testing of upper or lower respiratory tract secretions. This review additionally considers COVID-19 in immunosuppressed children, and also suggests a management algorithm for the few children who appear to present with life threatening infection, including the potential use of antiviral and immunomodulatory treatment. The most significant threat to global child health from SARS-CoV-2 is unlikely to be related to COVID 19 in children, but rather the socio-economic consequences of a prolonged pandemic.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Balasubramanian S,Rao NM,Goenka A,Roderick M,Ramanan AV

subject

Has Abstract

pub_date

2020-05-15 00:00:00

pages

435-442

issue

5

eissn

0019-6061

issn

0974-7559

pii

S097475591600159

journal_volume

57

pub_type

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