Abstract:
JUSTIFICATION:Gaucher disease (GD) is amongst the most frequently occurring lysosomal storage disorder in all ethnicities. The clinical manifestations and natural history of GD is highly heterogeneous with extreme geographic and ethnic variations. The literature on GD has paucity of information and optimal management guidelines for Indian patients. PROCESS:Gaucher Disease Task Force was formed under the auspices of the Society for Indian Academy of Medical Genetics. Invited experts from various specialties formulated guidelines for the management of patients with GD. A writing committee was formed and the draft guidelines were circulated by email to all members for comments and inputs. The guidelines were finalized in December 2016 at the annual meeting of the Indian Academy of Medical Genetics. OBJECTIVES:These guidelines are intended to serve as a standard framework for treating physicians and the health care systems for optimal management of Gaucher disease in India and to define unique needs of this patient population. RECOMMENDATIONS:Manifestations of GD are protean and a high index of suspicion is essential for timely diagnosis. Patients frequently experience diagnostic delays during which severe irreversible complications occur. Leucocyte acid b-glucosidase activity is mandatory for establishing the diagnosis of Gaucher disease; molecular testing can help identify patients at risk of neuronopathic disease. Enzyme replacement therapy for type 1 and type 3 Gaucher disease is the standard of care. Best outcomes are achieved by early initiation of therapy before onset of irreversible complications. However, in setting of progressive neurological symptoms such as seizures and or/ neuroregression, ERT is not recommended, as it cannot cross the blood brain barrier. The recommendations herein are for diagnosis, for initiation of therapy, therapeutic goals, monitoring and follow up of patients. We highlight that prevention of recurrence of the disease through genetic counseling and prenatal diagnosis is essential in India, due to uniformly severe phenotypes encountered in our population.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Puri RD,Kapoor S,Kishnani PS,Dalal A,Gupta N,Muranjan M,Phadke SR,Sachdeva A,Verma IC,Mistry PK,Gaucher Disease Task Force.subject
Has Abstractpub_date
2018-02-15 00:00:00pages
143-153issue
2eissn
0019-6061issn
0974-7559journal_volume
55pub_type
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journal_title:Indian pediatrics
pub_type: 杂志文章
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0470-4
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journal_title:Indian pediatrics
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
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doi:10.1007/s13312-013-0235-5
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journal_title:Indian pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian pediatrics
pub_type: 信件
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journal_title:Indian pediatrics
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doi:
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-01-15 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-11-15 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-02-01 00:00:00
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journal_title:Indian pediatrics
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doi:
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pub_type: 杂志文章,随机对照试验
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
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journal_title:Indian pediatrics
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doi:
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Indian pediatrics
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更新日期:2016-03-01 00:00:00