Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis.

Abstract:

OBJECTIVE:To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis. METHODS:Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocytic lymphohistiocytosis in IgM positive cases of scrub typhus was studied. RESULTS:Of the 35 children with unexplained fever and multi-systemic involvement, 15 children (9 boys) tested positive for scrub typhus. Thrombocytopenia, hypoalbuminemia and raised hepatic transaminases were observed in all children. Out of seven children evaluated for hemophagocytic lymphohistiocytosis. 3 met the criteria for hemophagocytosis. Two children (one with hemophagocytic lymphohistiocytosis) died. CONCLUSIONS:Scrub typhus is a common cause of unexplained fever in children in northern India. Hemophagocytic lymphohistiocytosis can occasionally complicate scrub typhus in children.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Sankhyan N,Saptharishi LG,Sasidaran K,Kanga A,Singhi SC

doi

10.1007/s13312-014-0470-4

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

651-3

issue

8

eissn

0019-6061

issn

0974-7559

journal_volume

51

pub_type

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