Abstract:
BACKGROUND:E-type prostaglandins (PGE1) can effectively maintain the patency of the ductus arteriosus in neonates. Its use, therefore and be life saving in infants born with ductus dependent congenital heart disease. Although PGE1 is available for over two decade in western world, it has been introduced in India only since April, 1995. OBJECTIVE:To assess the efficacy of PGE1 at our center. SETTING:Hospital based. METHOD:65 infants with ductus dependent congenital heart disease were included. Age at time of starting PGE1 infusion ranged from 18 hours to 39 days. Forty two of these were more than a week of age, 19 were more than 14 days, and two were above one month. PGE1 was started in an initial dose of 0.05 microgram/kg/min, decreased to 0.005-0.01 microgram/kg/min for maintenance. The indications for use of PGE1 were to increase pulmonary blood flow in 33 cases with pulmonary atresia, tricuspid atresia or critical pulmonic stenosis (Group I); to increase systemic blood flow in 15 cases with coarctation of aorta, hypoplastic left heart and interruption of aortic arch (Group II); to improve mixing in 13 cases of transposition of great arteries (Group III) and for improving the left ventricular volumes by keeping the duct open in 4 cases of transposition of great arteries with intact ventricular septum (Group IV). The efficacy of the drug was assessed by a rise on PaO2 and SaO2% determined for Group I & III, and by appearance of lower limbs pulses in Group II. Left ventricular volumes were serially measured by echocardiography in Group IV cases. RESULTS:The drug was successful in 62 of the 65 cases. There were two failures. One was a 39 days old baby with Ebstein's anomaly of tricuspid valve and pulmonary atresia and other was an eight days old baby with coarctation of aorta and renal failure. In addition, PGE1 could not be continued in another baby due to development of a linear skin rash locally. Side effects included apnea in 5 (9%) of 56 spontaneously breathing patients. Necrotizing enterocolitis, hyperpyrexia and jitteriness was sent in one case each. Six patients died. Two were related to PGE1, one due to failure, another due to its side effects. Definitive procedure were performed in 51 cases electively. PGE1 was used upto 13 days with sustained benefit. CONCLUSIONS:PGE1 is an effective drug for keeping the ductus open in infants with ductus dependent congenital heart disease. It can be used for neonates beyond the first week of life with efficacy. Apnea is a major side effect and close monitoring is essential.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Saxena A,Sharma M,Kothari SS,Juneja R,Reddy SC,Sharma R,Bhan A,Venugopal Pkeywords:
subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1063-9issue
11eissn
0019-6061issn
0974-7559journal_volume
35pub_type
临床试验,杂志文章abstract:JUSTIFICATION:Separate guidelines are needed for determining the optimal timing of intervention in children with congenital heart diseases in India, because of their frequent late presentation, undernutrition and co-existing morbidities. PROCESS:Guidelines emerged following expert deliberations at the National Consens...
journal_title:Indian pediatrics
pub_type: 杂志文章,实务指引
doi:
更新日期:2008-02-01 00:00:00
abstract::Trichotillomania, though uncommon, is one of the causes of unexplained hair loss, especially in children. Three girls in the age group of 4-6 years were observed in our pediatric dermatology clinic to have trichotillomania. In one child, there was co-existent alopecia areata. All were referred to the child guidance cl...
journal_title:Indian pediatrics
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更新日期:2003-01-01 00:00:00
abstract::Seven hundred and fifty nine children in different sectors were covered in this study, which was undertaken by observational techniques, questionnaires and physical examination. All children belonged to the age group of 6-14 years. Nearly 30% children had migrated from neighbouring districts and states. Almost 88% wer...
journal_title:Indian pediatrics
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Despite a reduction in disease burden of vaccine preventable diseases through childhood immunization, considerable progress needs to be made in terms of ensuring efficiency and equity of vaccination coverage. OBJECTIVE:To conduct a systematic review to identify and explore factors associated with inequities...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-012-0063-z
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abstract::Fifty seven male children between ages of 10-16 years engaged in the brassware industry at Moradabad in Northern India were studied for occupational morbidity. The finding were compared with those obtained in the children (n = 29) engaged in other ancillary units which did not involve exposure to the metal fumes and d...
journal_title:Indian pediatrics
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
abstract::A study of infant feeding practices was carried out as part of a larger longitudinal study of an urban birth cohort in an area of South Delhi, India. 802 mothers of children over 1 year of age were selected randomly for interview. The study group is considered to be a representative sampling of the economic, cultura...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:There is limited literature available on the phenotypic and mutation spectrum of Indian patients with Lysosomal storage disorders (LSD). OBJECTIVE:To elucidate the clinical, biochemical and mutation spectrum and to study the management options in Indian patients with lysosomal storage disorders. DESIGN:Des...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0192-4
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abstract::We report a 6 year old female child, who presented with history of right sided recurrent headache for four months. On diagnostic nasal endoscopy, a metallic foreign body was seen impacted between superior turbinate, middle turbinate and nasal septum which was removed using pediatric nasal endoscope. Following removal,...
journal_title:Indian pediatrics
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更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To compare the effect of Kangaroo mother care (KMC) and conventional methods of care (CMC) on growth in LBW babies (> 2000 g). STUDY DESIGN:Randomized controlled trial. SETTING:Level III NICU of a teaching institution in western India. SUBJECTS:206 neonates with birth weight < 2000 g. INTERVENTION:The sub...
journal_title:Indian pediatrics
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2008-01-01 00:00:00
abstract::Fifty eight (16%) of the 362 patients, who reported to Dermatology and STD Department with symptoms pertaining to their genitourinary system were below 14 years of age. Fifty four (93.1%) of these children belonged to families of lower socio-economic strata. All the children were slum dwellers and none of them had stu...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-11-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Indian pediatrics
pub_type: 杂志文章
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0341-z
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journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme. DESIGN:Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 20...
journal_title:Indian pediatrics
pub_type: 杂志文章
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章,多中心研究
doi:
更新日期:2008-09-01 00:00:00
abstract::Clinical and hematological data of 9 cases with factor XIII deficiency is highlighted. The age at first bleed ranged from 3 days of life to 1 year. Seven of these 9 cases had bleeding from the umbilicus, 3 had recurrent subcutaneous and muscle hematomas, while 4 cases had CNS bleeds of which 3 expired. Routine coagulo...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00
abstract::Andersen Tawil syndrome is a rare type of channelopathy characterized by the presence of periodic paralysis, cardiac arrhythmia (prolonged QT interval or ventricular arrhythmia) and distinct dysmorphic abnormalities. It is a type of potassium channelopathy that occurs sporadically or by autosomal dominant inheritance....
journal_title:Indian pediatrics
pub_type: 杂志文章
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journal_title:Indian pediatrics
pub_type: 杂志文章,评审
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abstract::Atypical celiac disease (ACD) presenting in childhood has rarely been documented from India. The present retrospective study analyzed features of atypical celiac disease over a 5-year period. Patients were diagnosed to have Celiac Disease (CD) as per the standard ESPGHAN criteria. The biochemical and hematological par...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::We conducted a case control study to compare the quality of life (QOL) in 40 cases of HIV infected children and 40 demographically matched controls with other chronic ailments at a referral hospital in Northern India. Quality of life among HIV infected children was significantly better in psychosocial (P=0.008), emoti...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0300-0
更新日期:2013-12-01 00:00:00
abstract::The prevalence of vitamin A deficiency was estimated in 366 rural children in the age group of 1 to 15 years. In a systematically selected subsample of 90 children, the dietary intake of vitamin A was assessed. The prevalence of vitamin A deficiency signs ranged from 24.1 to 34.8%. The adequacy of dietary intake of vi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::The year 2013 marks 50 years of both newborn screening and the Indian Academy of Pediatrics. India has seen a lot of change in terms of motivation, evolution and implementation of newborn screening as pilot projects for few disorders. Facilities for implementing screening using tandem mass spectrometry or what is term...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0187-9
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To assess the glycometabolic function in chronically transfused patients of beta- thalassemia major in terms of glucose tolerance, insulin secretion, insulin resistance index, and beta cell function index and to determine their relationship with clinical and biochemical profile. METHODS:30 homozygous thalass...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00