Abstract：
OBJECTIVE:To identify the pattern of congenital heart defects (CHD) in children with Down Syndrome (DS) in an Omani population, and compare it with CHD in children without DS and with historical cohorts from populations with low prevalence of consanguinity. SETTING:Open-access Paediatric Echocardiography Clinic at Sultan Qaboos University Hospital, Muscat, Oman. DESIGN:Prospective study. METHODS:All children with DS referred to the Clinic from 1995-1998 formed the subjects (Group I). Children without DS or other known associations of CHD seen at the clinic during the same period served as controls (Group II). Two-dimensional echo-Doppler studies were performed on both groups and the results compared. RESULTS:CHD were detected in 54/90 (60%) children in Group I, compared to 698/2122 (32.9%) in Group II (P<0.001). The common CHD in Group I included secundum atrial septal defect (ASD; 18/54), atrioventricular septal defect (AVSD; 15/54) and ventricular septal defect (VSD; 14/54), and in Group II included ASD (175/698), VSD (175/698), patent ductus arteriosus (123/698), pulmonary stenosis (PS; 76/698) and AVSD (35/698). AVSD was more common (P <0.001) and PS less common (P = 0.03) in Group I. Aortic stenosis, coarctation of aorta, transposition of great arteries and complex heart diseases were not detected. Compared to several studies from populations with low prevalence of consanguineous marriages, our study showed a higher frequency of CHD in DS (P <0.05). CONCLUSION:A high frequency of CHD was documented in DS-children from a population with widely prevalent consanguinity. AVSD was most frequent in DS. An interesting observation was the relative rarity of some CHD in the DS population studied.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Venugopalan P,Agarwal AKkeywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
398-403issue
5eissn
0019-6061issn
0974-7559journal_volume
40pub_type
杂志文章abstract：OBJECTIVE:To analyze variation in rotavirus-positivity using simple alternative statistical measures. METHODS:Hospital-based rotavirus surveillance among children admitted with acute gastroenteritis between 2005 and 2009. Prevalence, adjusted proportions and symmetrized index were calculated. RESULTS:Rotavirus preval...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0898-9
更新日期：2016-07-08 00:00:00
abstract：:Intravenously administered rehydration therapy was compared with orally administered rehydration therapy for treating children with diarrhea in a clinical study of 3000 children admitted to the Medical College Hospital, Kottayam, India. Oral rehydration was more effective and safer than intravenously administered flu...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:We studied the level of food insecurity among households with HIV-infected children and its relationship with childhood nutritional indicators. Among the 147 children assessed, food insecurity was present in 59% of households. Majority of children with stunting belonged to-food insecure families. Stunting and Underwei...
journal_title：Indian pediatrics
pub_type： 信件
doi：
更新日期：2015-03-08 00:00:00
abstract：:This report is based on observations during the conduct of a study of hypocalcemia in infants and children. In a study of 50 cases, 13 exclusively breast fed infants manifesting with hypocalcemic seizures were confirmed to have vitamin D deficiency. None of the 13 infants had received vitamin D supplementation. All of...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To study the clinical spectrum and management of choledochal cyst in children below 12 years of age. DESIGN:Descriptive study. SETTING:Tertiary care hospital. METHODS:Twenty three children with choledochal cysts were managed between January 1991 to September 1997 and their clinical details, investigations ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：NEED AND PURPOSE OF REVIEW:A number of newer anti-epileptic drugs have been developed in the last few years to improve the treatment outcomes in epilepsy. In this review, we discuss the use of newer anti-epileptic drugs in children. METHODS USED FOR LOCATING, SELECTING, EXTRACTING AND SYNTHESIZING DATA:MEDLINE search ...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-013-0284-9
更新日期：2013-11-08 00:00:00
abstract：OBJECTIVE:To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium. METHODS:This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE cr...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-015-0586-1
更新日期：2015-02-01 00:00:00
abstract：:Pathologic fractures in children may be due to various causes. Rarely, it may be the presenting symptom of neurofibromatosis. A misdiagnosis of Rickets and Vitamin D supplementation in such a case may wreak havoc in the form of iatrogenic hypervitaminosis D. We report one such case. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-010-0137-8
更新日期：2010-10-01 00:00:00
abstract：:A 12-year-old male child reported with history of fever for last seven years. Hepatosplenomegaly, hepatic and bone marrow granulomas were the main features. Idiopathic Granulomatous Hepatitis (IGH), a rare syndrome amenable to immunosuppressive therapy was diagnosed. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To compare the rate of optimal position of UVC between modified Shukla's formula and JSS formula. METHODS:Babies requiring umbilical vein catheterization were randomized to either Shukla or JSS formula group. Post-procedure X-ray was taken to check the tip position. Tip of the UVC just above the diaphragm (T...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2019-03-15 00:00:00
abstract：: ...
journal_title：Indian pediatrics
pub_type： 评论,社论
doi：
更新日期：2018-11-15 00:00:00
abstract：:The phenotypic description of SHORT syndrome (OMIM- 269880) is expanding since its initial description in 1975. There have been 26 case reports till date but the genetic locus of this syndrome is elusive. Involvement of PITX2 gene initially envisaged is probably is not the only gene involved but has an important role ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0099-8
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:To determine the clinical profile of children with Henoch-Schonlein purpura (HSP). DESIGN:Hospital based descriptive follow-up study. SUBJECTS:45 patients attending the Pediatric Rheumatology and Immunology clinic over the last 4 years. RESULTS:The patients were aged between 2.5-12 years with a male to fem...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates. DESIGN:Open labeled randomized controlled trial. SETTING:Neonatal intensive care unit of a level II unit from India, from November 2008 to September 2009. PARTICIPANTS:All term and lat...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13312-013-0218-6
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Management of pyothorax and pneumothorax requires aspiration and/or intercostal drainage. CASE CHARACTERISTICS:We present two cases which were complicated by instrument-related events resulting in breakage of needle or intercostal drainage tube resulting in pleural foreign body. INTERVENTION/OUTCOME:The pa...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0848-6
更新日期：2016-04-01 00:00:00
abstract：:The prevalence of vitamin A deficiency was estimated in 366 rural children in the age group of 1 to 15 years. In a systematically selected subsample of 90 children, the dietary intake of vitamin A was assessed. The prevalence of vitamin A deficiency signs ranged from 24.1 to 34.8%. The adequacy of dietary intake of vi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:A 13-year old girl presented with a decade long anemia, diffuse alveolar hemorrhage and interstistial lung disease; was eventually diagnosed as ANCA associated vasculitis. High index of suspicion is thus warranted for alternative diagnosis in chronic anemia, despite increased prevalence of infectious diseases and nutr...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0042-z
更新日期：2013-02-01 00:00:00
abstract：Background:We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). METHODS:We analyzed the clinical and laboratory findings of childr...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-11-15 00:00:00
abstract：:There is a paucity of data on the incidence of sporadic viral hepatitis in Indian children. Clinical, biochemical and etiological profile of 54 patients with acute viral hepatitis was evaluated. Of these, 32 (59.25%) patients had Hepatitis A, 18 (33.33%) had NANB, 2 (3.7%) had Hepatitis B and 2 (3.7%) concurrent Hepat...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Postictal values of plasma prolactin levels were measured in 15 children with generalized seizures, 8 children with pseudoseizures and 6 control subjects. In patients with generalized seizure, the mean plasma prolactin level was 28.6 +/- 2.3 ng/ml, whereas in patients with pseudoseizures and in controls, its mean valu...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Seven hundred and fifty nine children in different sectors were covered in this study, which was undertaken by observational techniques, questionnaires and physical examination. All children belonged to the age group of 6-14 years. Nearly 30% children had migrated from neighbouring districts and states. Almost 88% wer...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：CONTEXT:Increased prevalence of obesity in childhood and adolescence, defined by the use of body mass index (BMI), has drawn attention towards direct measurement of body fat. OBJECTIVE:To develop age-and sex-specific reference distribution of body fat in apparently healthy North-Indian children in the age group of 7-1...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0237-3
更新日期：2013-09-01 00:00:00
abstract：: ...
journal_title：Indian pediatrics
pub_type： 信件
doi：
更新日期：2019-02-15 00:00:00
abstract：OBJECTIVE:To study the etiological profile and patterns of clinical presentation of nephrocalcinosis. METHODS:In this observational study, patients 18 years or younger, referred to the pediatric nephrology clinic with nephrocalcinosis were evaluated for etiology. Symptoms/signs at presentation, estimated glomerular fi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-05-15 00:00:00
abstract：OBJECTIVE:To evaluate simple clinical signs of illness in young infants (0 to 2 months) and to correlate with WHO IMCI algorithm (7 days-2 months). DESIGN:Prospective observational. Study conducted in the outpatient department and emergency room of a pediatric tertiary level hospital. METHODS:Four hundred and ninety ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：JUSTIFICATION:There is a need to revise/review recommendations regarding existing vaccines in view of current developments in vaccinology. PROCESS:Advisory Committee on Vaccines and Immunization Practices (ACVIP) of Indian Academy of Pediatrics (IAP) reviewed the new evidence, had two meetings, and representatives of ...
journal_title：Indian pediatrics
pub_type： 杂志文章,实务指引
doi：
更新日期：2018-12-15 00:00:00
abstract：BACKGROUND:There is limited literature available on the phenotypic and mutation spectrum of Indian patients with Lysosomal storage disorders (LSD). OBJECTIVE:To elucidate the clinical, biochemical and mutation spectrum and to study the management options in Indian patients with lysosomal storage disorders. DESIGN:Des...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0192-4
更新日期：2012-10-01 00:00:00
abstract：:One hundred nine patients presenting with ambiguous genitalia over the past 10 years (year 1995 to 2004) to Pediatric Endocrine Service of our hospital were reviewed. On the basis of clinical and investigative evaluation like hormonal and biochemical estimations, imaging studies, karyotype and invasive techniques like...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：:Transfusion-associated graft-versus-host disease (TA-GVHD) is a dreaded complication in immunocompromized hosts. The diagnosis is often delayed because of lack of awareness and the non-specific clinical features. More than 90% patients succumb to refractory infections. The only effective preventive measure is administ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Three hundred and fifty stool samples from patients with acute diarrhea and 30 samples from normal healthy controls were examined for the presence of various parasitic and bacterial enteropathogens by conventional techniques. Cryptosporidium oocysts were detected in 15 out of 350 (4.3%) fecal samples. In 10 cases (2.9...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
