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Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

Abstract：

:BAF (Brg/Brm-associated factors) complexes play important roles in development and are linked to chromatin plasticity at selected genomic loci. Nevertheless, a full understanding of their role in development and chromatin remodeling has been hindered by the absence of mutants completely lacking BAF complexes. Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in active chromatin marks (H3K9Ac), a global increase in repressive marks (H3K27me2/3), and downregulation of gene expression. We demonstrate that BAF complexes interact with H3K27 demethylases (JMJD3 and UTX) and potentiate their activity. Importantly, BAF complexes are indispensable for forebrain development, including proliferation, differentiation, and cell survival of neural progenitor cells. Our findings reveal a molecular mechanism mediated by BAF complexes that controls the global transcriptional program and chromatin state in development.

journal_name

Cell Rep

journal_title

Cell reports

authors

Narayanan R,Pirouz M,Kerimoglu C,Pham L,Wagener RJ,Kiszka KA,Rosenbusch J,Seong RH,Kessel M,Fischer A,Stoykova A,Staiger JF,Tuoc T

doi

10.1016/j.celrep.2015.10.046

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1842-54

issue

9

issn

2211-1247

pii

S2211-1247(15)01216-4

journal_volume

13

pub_type

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