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The Role of the Kidney and SGLT2 Inhibitors in Type 2 Diabetes.

Abstract：

:Effective glycemic control reduces the risk for diabetes-related complications. However, the majority of patients with type 2 diabetes still do not achieve glycemic targets. Beyond metformin therapy, current practice guidelines for the management of type 2 diabetes recommend individualized treatment based on patient and agent characteristics. The sodium glucose cotransporter type 2 (SGLT2) inhibitors represent a novel treatment strategy, independent of impaired beta-cell function and insulin resistance. SGLT2 inhibitors decrease renal glucose reabsorption, thereby increasing urinary glucose excretion with subsequent reduction in plasma glucose levels and glycosylated hemoglobin concentrations. Current evidence suggests that they are effective as monotherapy or as add-ons to metformin either alone, or in combination with other oral glucose-lowering agents or insulin. They are generally well tolerated, though rates of lower urinary tract and genital mycotic infections are slightly increased. The advantages of this class include modest reductions in body weight and blood pressure, and low risk for hypoglycemia. Long-term safety data and results of ongoing cardiovascular outcome studies are awaited so we can fully understand the role that SGLT2 inhibitors will play in the comprehensive management of type 2 diabetes.

journal_name

Can J Diabetes

journal_title

Canadian journal of diabetes

authors

Katz PM,Leiter LA

doi

10.1016/j.jcjd.2015.09.001

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

S167-75

eissn

1499-2671

issn

2352-3840

pii

S1499-2671(15)00629-2

journal_volume

39 Suppl 5

pub_type

杂志文章,评审

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