Abstract：
:Cerebral edema (CE) is a rare but potentially fatal complication of diabetic ketoacidosis (DKA) in children with type 1 diabetes. CE is frequently mentioned as being more common in young children. The primary objective of this study was to review the evidence suggesting that younger age is a risk factor for the development of CE during DKA. The secondary objective was to assess if younger children are at a higher risk of DKA and severe DKA. A literature review was performed, and studies which reported the frequency of CE, DKA and severe DKA in children <3 and 3 to 5 years of age were included. Among the 6 studies reporting the frequency of CE that were identified, 5 good-quality studies found no significant association between younger age and higher risk of CE. Twenty-seven studies (DKA frequency: 11.3% to 54%) reported DKA frequency as a function of age. Most published studies found a higher frequency of DKA in children <5 years of age (20/25 studies), and in particular in those in the first 2 to 3 years of life (8/8 studies). There was inconclusive evidence to determine whether the severity of DKA was influenced by age. In conclusion, the commonly held view that CE is more common in younger children is not supported by the existing literature. Published data suggest that DKA (and possibly severe DKA) is more common in very young children. Regardless of age, all children with DKA should be monitored carefully for the development of CE.
journal_name
Can J Diabetesjournal_title
Canadian journal of diabetesauthors
Glackin S,Metzger D,Hanas R,Chanoine JPdoi
10.1016/j.jcjd.2019.04.013subject
Has Abstractpub_date
2020-02-01 00:00:00pages
111-118issue
1eissn
1499-2671issn
2352-3840pii
S1499-2671(18)30709-3journal_volume
44pub_type
杂志文章,评审abstract：:The prevalence of chronic metabolic diseases, such as diabetes, cardiovascular diseases and cancer, is increasing around the world. Nutritional interventions can reduce the prevalence and provide effective treatment, even when weight loss is not dramatic. The 2013 Canadian Diabetes Association Clinical Practice Guidel...
journal_title：Canadian journal of diabetes
pub_type： 历史文章,杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2017.08.242
更新日期：2017-10-01 00:00:00
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journal_title：Canadian journal of diabetes
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.02.060
更新日期：2013-04-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:Examining the diets of people living with type 2 diabetes may improve understanding of how diet affects disease progression. We derived dietary patterns in adults living with type 2 diabetes and explored associations among patterns, sociodemographic variables and cardiometabolic risk factors. METHODS:Dietar...
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pub_type： 杂志文章
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2020-06-17 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2014.12.001
更新日期：2015-08-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.07.002
更新日期：2018-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2020-08-10 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.01.004
更新日期：2015-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.07.005
更新日期：2017-02-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.07.029
更新日期：2013-10-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.02.013
更新日期：2016-10-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章,撤回出版物
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更新日期：2016-05-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,随机对照试验
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更新日期：2017-04-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.04.001
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:We evaluated the prevalence of type 2 diabetes, obesity and metabolic syndrome according to International Diabetes Federation criteria in the First Nations Cree community of Mistissini, Quebec. METHODS:A cross-sectional study of 172 adults was performed as part of a broader regional environmental study. RES...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/S1499-2671(09)33006-3
更新日期：2009-01-01 00:00:00
