Abstract：
OBJECTIVE:To describe the use patterns of metformin-based antidiabetic regimens in patients with type 2 diabetes and to identify predictors of initiating metformin monotherapy. METHODS:By using administrative databases from Alberta, Canada, we identified all metformin users ages 65 years and older between 1998 and 2010. Rates of metformin use, either alone or in combination with other antidiabetic drugs, were evaluated at 6-month intervals. All rates were direct age- and sex-standardized using the 2006 Alberta census. Trends over time were assessed using Joinpoint regression software (National Cancer Institute, USA). In addition, a cohort of new users of antidiabetic drugs was identified and multivariable logistic regression models were constructed to identify independent predictors of receiving initial treatment with metformin monotherapy. RESULTS:Metformin monotherapy became the most common metformin-based regimen (508 of 1000 persons in 2010). Sulfonylureas were the most prevalent add-on drug to metformin; however, their use significantly decreased from 548 of 1000 in 1998 to 182 of 1000 persons in 2010 (67% reduction; p<0.001), with more patients using newer drugs, mainly thiazolidinediones (103 of 1000 persons in 2007). Combination therapy of metformin with glinides or insulin also significantly increased during the same period. Compared with patients starting sulfonylurea monotherapy, patients starting metformin monotherapy were younger, had fewer cardiovascular complications and lower healthcare use rates. CONCLUSIONS:In accordance with the clinical practice guidelines, patients with type 2 diabetes manage hyperglycemia mainly with metformin monotherapy and sulfonylureas are the most common add-on therapy. Older age and the presence of nephropathy, liver disease or congestive heart failure were important predictors for starting sulfonylurea monotherapy rather than metformin monotherapy.
journal_name
Can J Diabetesjournal_title
Canadian journal of diabetesauthors
Abdelmoneim AS,Eurich DT,Gamble JM,Simpson SHdoi
10.1016/j.jcjd.2013.04.008subject
Has Abstractpub_date
2013-12-01 00:00:00pages
394-400issue
6eissn
1499-2671issn
2352-3840pii
S1499-2671(13)00712-0journal_volume
37pub_type
杂志文章abstract：OBJECTIVE:With the expanding armamentarium of noninsulin therapies for type 2 diabetes mellitus, the use of insulin with various oral agents is becoming more common. In this study, we assessed the efficacy and cardiovascular (CV) safety of the dipeptidyl peptidase-4 inhibitor linagliptin as add-on to insulin in patient...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcjd.2015.06.010
更新日期：2016-02-01 00:00:00
abstract：:We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.02.007
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:South Asian immigrants are generally healthy upon arrival, but precipitously develop diabetes after immigration. Whether cultural and psychosocial factors contribute to diabetes risk in this ethnic minority group remains unclear. Existing prediction models focus primarily on clinical and lifestyle factors. T...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2019.04.015
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:1) to describe current utilization of e-mail in the clinical care of patients with diabetes; and 2) to identify barriers to and facilitators of the adoption of e-mail in diabetes care. METHODS:Participants included diabetes care providers, including 9 physicians and 7 allied health professionals (AHPs). Par...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.07.001
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To explore perspectives on the meaning of health to Aboriginal adults and youth living in a northern Manitoba First Nations community. METHODS:Six focus groups with 29 youth and individual interviews with 10 adults were audio-recorded, transcribed verbatim and thematically analyzed. RESULTS:Adults and older...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/S1499-2671(08)22008-3
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:Diabetes frequently coexists with other conditions, resulting in poorer diabetes self-management and quality of life, higher risk for diabetes-related complications and higher health service use compared to those with diabetes only. Few Canadian studies have undertaken a comprehensive, population-level analy...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.09.002
更新日期：2016-02-01 00:00:00
abstract：:Epidemiological studies suggest that adults and children who are habitual short sleepers tend to have a higher body mass index, fat percentage and abdominal circumference when compared to average-duration sleepers. Reduced or disturbed sleep is also associated with certain predictors of type 2 diabetes, such as glucos...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.02.060
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:We aimed to build a risk score model to screen out the patients at high-risk status so as to prevent or delay the conversion of prediabetes to diabetes. METHODS:The population were divided into 2 groups: 1 was an exploratory population, and the other was a validation population. All the data were extracted ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.02.013
更新日期：2016-10-01 00:00:00
abstract：:The prevalence of chronic metabolic diseases, such as diabetes, cardiovascular diseases and cancer, is increasing around the world. Nutritional interventions can reduce the prevalence and provide effective treatment, even when weight loss is not dramatic. The 2013 Canadian Diabetes Association Clinical Practice Guidel...
journal_title：Canadian journal of diabetes
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.jcjd.2016.05.005
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD becaus...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.07.005
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:Individuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by either pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting hypoglycemia, but it remains unclear whic...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2020.03.003
更新日期：2020-12-01 00:00:00
abstract：:Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMe...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,meta分析
doi：10.1016/j.jcjd.2017.12.002
更新日期：2018-10-01 00:00:00
abstract：:Diabetes mellitus is a disabling, chronic cardiovascular and medical disease with a tremendous health, social and economic burden in our ageing communities. It has a prevalence of 10% to 30% in people older than 65 years of age, and more than half of all subjects with diabetes in the United States are older than 60 ye...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2015.09.004
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:The self-monitoring of blood glucose plays a critical role in management of diabetes mellitus. Although laboratory comparisons of glucose meter accuracy are often acceptable, clinical comparisons show frequent inaccuracies. In this paper, we evaluate the accuracy of self-monitoring blood glucose meters using ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,撤回出版物
doi：10.1016/j.jcjd.2016.04.004
更新日期：2016-05-01 00:00:00
abstract：:The most common presentation of chronic disease is multimorbidity. Disease management strategies are similar across most chronic diseases. Given the prevalence of multimorbidity and the commonality in approaches, fragmented single disease management must be replaced with integrated care of the whole person. The Albert...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.04.001
更新日期：2013-08-01 00:00:00
abstract：:Diabetic mastopathy is an uncommon, benign breast condition seen in type 1 and less frequently type 2 diabetic patients. It is characterized by a dense fibrous stromal proliferation of breast tissue, clinically mimicking cancerous masses, thus leading to worrisome investigations. Clinicians and pathologists must disti...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.12.008
更新日期：2014-10-01 00:00:00
abstract：:Hyperglycemia is a significant cause of morbidity and mortality, often resulting in adverse outcomes. This review aimed to identify predictors of adverse outcomes, such as repeated hospital visits, hospitalization or death, in patients presenting to the emergency department (ED) with hyperglycemia. Electronic searches...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2018.11.008
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:This article describes a qualitative research study that examines the encounters by patients of low socioeconomic status with a group medical visit (GMV) program for individuals with or at risk for diabetes. The goal of this study was to generate insights that could be used to guide the development of an inne...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2014.03.012
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:No research to date has compared the beliefs of adolescents, parents and physicians with respect to type 1 diabetes mellitus self-care perceptions and barriers. This study examined how adolescents with type 1 diabetes, their parents and physicians perceive 4 key diabetes self-care behaviours (testing blood gl...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.02.057
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To examine the relationship of inadequate health literacy (HL) with changes in depressive symptoms, health-related quality of life and cardiometabolic outcomes in patients with type 2 diabetes mellitus recently screened positive for depression. METHODS:Secondary analysis of data from a clinical trial (N=154)...
journal_title：Canadian journal of diabetes
pub_type： 临床试验,杂志文章
doi：10.1016/j.jcjd.2014.11.005
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:There are currently no recommendations on following the ketogenic diet (KD) in the context of diabetes and, therefore, health-care professionals may not be comfortable in supporting this dietary regimen. In this qualitative study, we aim to understand the perspective of patients with diabetes when following ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2020.06.016
更新日期：2020-06-27 00:00:00
abstract：:While dysglycemia (hyperglycemia, hypoglycemia and glucose variability) is clearly associated with increased mortality in critically ill patients, target range of blood glucose control remains controversial. Standardized insulin infusion protocols constitute the basis of treatment of these patients. The choice of prot...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2014.01.016
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:(1) to describe pediatric patients with T1D and their caregivers' perceptions of measures of glycemic control (hemoglobin [A1C] and blood glucose [BG] levels) and (2) to determine the relationship between patients' and caregivers' perceptions of measures of glycemic control with actual A1C levels and adheren...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.07.002
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVES:Although metformin has traditionally been avoided in pregnancy, evidence now supports its safety and efficacy for management of gestational diabetes mellitus (GDM). The primary objective of this study was to evaluate the clinical impact of a metformin-based approach for GDM management through assessment of p...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2019.06.005
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS:Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and we...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.03.003
更新日期：2018-02-01 00:00:00
abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.jcjd.2017.02.003. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-busines...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.02.003
更新日期：2017-04-05 00:00:00
abstract：OBJECTIVES:Examining the diets of people living with type 2 diabetes may improve understanding of how diet affects disease progression. We derived dietary patterns in adults living with type 2 diabetes and explored associations among patterns, sociodemographic variables and cardiometabolic risk factors. METHODS:Dietar...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.11.006
更新日期：2016-08-01 00:00:00
abstract：:Patients with diabetes who are in emerging adulthood, defined as the life stage between 18 and 29 years of age, have unique challenges in managing their illness and are at risk for acute complications and loss to follow up. This study's objective was to describe emergency department (ED) utilization because of hypergl...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2017.06.016
更新日期：2018-06-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF), a member of neurotrophin growth factor family, physiologically mediates induction of neurogenesis and neuronal differentiation, promotes neuronal growth and survival and maintains synaptic plasticity and neuronal interconnections. Unlike the central nervous system, its secreti...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2016.08.228
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To enhance the dietary education presented to women with gestational diabetes (GDM) by exploring the reasons and experiences that women with GDM reported in making their food-choice decisions after receipt of dietary education from a healthcare professional. METHODS:Food Choice Map (FCM) semi-structured in-d...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.08.263
更新日期：2014-02-01 00:00:00
