Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans.

Abstract:

:We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic possibilities.

journal_name

Can J Diabetes

authors

Liminet C,Vouillarmet J,Chikh K,Disse E

doi

10.1016/j.jcjd.2016.02.007

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

462-465

issue

5

eissn

1499-2671

issn

2352-3840

pii

S1499-2671(15)30022-8

journal_volume

40

pub_type

杂志文章
  • Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus.

    abstract:OBJECTIVES:Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in p...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2015.01.004

    authors: Ayhan H,Kasapkara HA,Aslan AN,Durmaz T,Keleş T,Akçay M,Akar Bayram N,Baştuğ S,Bilen E,Sarı C,Bozkurt E

    更新日期:2015-08-01 00:00:00

  • Testing for albuminuria in 2014.

    abstract::Routine quantification of urinary albumin levels is recommended for all Canadians with diabetes, yet many controversies remain when interpreting these tests. Elevated levels of albuminuria have traditionally been labeled as either microalbuminuria, representing 30 to 300 mg of albuminuria per day (a range not reliably...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2014.07.221

    authors: McFarlane PA

    更新日期:2014-10-01 00:00:00

  • Perceived Barriers to and Facilitators of Patient-to-Provider E-Mail in the Management of Diabetes Care.

    abstract:OBJECTIVES:1) to describe current utilization of e-mail in the clinical care of patients with diabetes; and 2) to identify barriers to and facilitators of the adoption of e-mail in diabetes care. METHODS:Participants included diabetes care providers, including 9 physicians and 7 allied health professionals (AHPs). Par...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2015.07.001

    authors: Popeski N,McKeen C,Khokhar B,Edwards A,Ghali WA,Sargious P,White D,Hebert M,Rabi DM

    更新日期:2015-12-01 00:00:00

  • Association Between Systolic Blood Pressure and Cardiovascular Inpatient Cost Moderated by Peer-Support Intervention Among Adult Patients with Type 2 Diabetes: A 2-Cohort Study.

    abstract:OBJECTIVES:People with type 2 diabetes and increased systolic blood pressure (SBP) are at high risk of cardiovascular disease (CVD). In this study, we aimed to investigate the association between CVD-related hospital payments and SBP and tested whether this association is influenced by diabetes peer support. METHODS:T...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2020.07.008

    authors: Yu D,Cai Y,Graffy J,Holman D,Zhao Z,Simmons D

    更新日期:2020-08-10 00:00:00

  • Risk Factors for Adverse Outcomes in Adult and Pediatric Patients With Hyperglycemia Presenting to the Emergency Department: A Systematic Review.

    abstract::Hyperglycemia is a significant cause of morbidity and mortality, often resulting in adverse outcomes. This review aimed to identify predictors of adverse outcomes, such as repeated hospital visits, hospitalization or death, in patients presenting to the emergency department (ED) with hyperglycemia. Electronic searches...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2018.11.008

    authors: Siddiqi L,VanAarsen K,Iansavichene A,Yan J

    更新日期:2019-07-01 00:00:00

  • Culturally Tailored Self-Management Interventions for South Asians With Type 2 Diabetes: A Systematic Review.

    abstract::Diabetes mellitus is one of the most common chronic diseases worldwide and a leading cause of morbidity and mortality. A high prevalence of type 2 diabetes mellitus has been noted among the South Asian population, in general, and migrant South Asians. Self-management is considered a proponent to the management of diab...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2019.04.010

    authors: Navodia N,Wahoush O,Tang T,Yost J,Ibrahim S,Sherifali D

    更新日期:2019-08-01 00:00:00

  • A Simple Score Model to Assess Prediabetes Risk Status Based on the Medical Examination Data.

    abstract:OBJECTIVES:We aimed to build a risk score model to screen out the patients at high-risk status so as to prevent or delay the conversion of prediabetes to diabetes. METHODS:The population were divided into 2 groups: 1 was an exploratory population, and the other was a validation population. All the data were extracted ...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2016.02.013

    authors: Ouyang P,Guo X,Shen Y,Lu N,Ma C

    更新日期:2016-10-01 00:00:00

  • Implementation and Evaluation of the "Metformin First" Protocol for Management of Gestational Diabetes.

    abstract:OBJECTIVES:Although metformin has traditionally been avoided in pregnancy, evidence now supports its safety and efficacy for management of gestational diabetes mellitus (GDM). The primary objective of this study was to evaluate the clinical impact of a metformin-based approach for GDM management through assessment of p...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2019.06.005

    authors: Kumar R,Lowe J,Thompson-Hutchison F,Steinberg D,Shah B,Lipscombe L,Halperin I

    更新日期:2019-12-01 00:00:00

  • Diabetes and related metabolic conditions in an aboriginal cree community of quebec, Canada.

    abstract:OBJECTIVE:We evaluated the prevalence of type 2 diabetes, obesity and metabolic syndrome according to International Diabetes Federation criteria in the First Nations Cree community of Mistissini, Quebec. METHODS:A cross-sectional study of 172 adults was performed as part of a broader regional environmental study. RES...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/S1499-2671(09)33006-3

    authors: Chateau-Degat ML,Pereg D,Egeland GM,Nieboer E,Bonnier-Viger Y,Laouan-Sidi EA,Dannenbaum D,Dewailly E

    更新日期:2009-01-01 00:00:00

  • The Short Version of the Activities-Specific Balance Confidence Scale for Older Adults with Diabetes-Convergent, Discriminant and Concurrent Validity: A Pilot Study.

    abstract:OBJECTIVES:The short version of the Activities-Specific Balance Confidence Scale (ABC-6) is advantageous in busy clinical or research settings because it can be administered in less time than the original 16-item Activities-Specific Balance Confidence Scale (ABC-16). This pilot study examined the convergent, discrimina...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2016.10.007

    authors: Hewston P,Deshpande N

    更新日期:2017-06-01 00:00:00

  • TITRATION: A Randomized Study to Assess 2 Treatment Algorithms with New Insulin Glargine 300 units/mL.

    abstract:OBJECTIVE:It was uncertain whether an algorithm that involves increasing insulin dosages by 1 unit/day may cause more hypoglycemia with the longer-acting insulin glargine 300 units/mL (GLA-300). The objective of this study was to compare safety and efficacy of 2 titration algorithms, INSIGHT and EDITION, for GLA-300 in...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jcjd.2017.06.007

    authors: Yale JF,Berard L,Groleau M,Javadi P,Stewart J,Harris SB

    更新日期:2017-10-01 00:00:00

  • Review of Dietary Practices of the 21st Century: Facts and Fallacies.

    abstract::The prevalence of chronic metabolic diseases, such as diabetes, cardiovascular diseases and cancer, is increasing around the world. Nutritional interventions can reduce the prevalence and provide effective treatment, even when weight loss is not dramatic. The 2013 Canadian Diabetes Association Clinical Practice Guidel...

    journal_title:Canadian journal of diabetes

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.jcjd.2016.05.005

    authors: Subhan FB,Chan CB

    更新日期:2016-08-01 00:00:00

  • The Effect of Omega-3 on Circulating Adiponectin in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract::Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMe...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jcjd.2017.12.002

    authors: Bahreini M,Ramezani AH,Shishehbor F,Mansoori A

    更新日期:2018-10-01 00:00:00

  • Uptake of Community Pharmacist-Delivered MedsCheck Diabetes Medication Review Service in Ontario between 2010 and 2014.

    abstract:OBJECTIVES:The objective of the study was to describe the demographic and clinical characteristics of MedsCheck Diabetes (MCD) recipients in Ontario between program launch on September 1, 2010, and March 31, 2014. METHODS:This cohort study leveraged linked administrative claims data. Trends in MCD claims and recipient...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2016.12.001

    authors: MacCallum L,Consiglio G,MacKeigan L,Dolovich L

    更新日期:2017-06-01 00:00:00

  • Impact of Resistance Training on Factors Involved in the Development of New-Onset Diabetes After Transplantation in Renal Transplant Recipients: An Open Randomized Pilot Study.

    abstract:OBJECTIVES:New-onsetdiabetes after transplant (NODAT) is a major contributor to cardiovascular disease after transplantation. Kidney transplantation (KT) recipients have low levels of exercise capacity. Resistance training (RT) might be of special benefit in this population because underlying disease and immunosuppress...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2015.08.014

    authors: Karelis AD,Hébert MJ,Rabasa-Lhoret R,Räkel A

    更新日期:2016-10-01 00:00:00

  • Is YouTube Useful as a Source of Health Information for Adults With Type 2 Diabetes? A South Asian Perspective.

    abstract:OBJECTIVES:To investigate the content, quality and popularity of information about type 2 diabetes available on YouTube. METHODS:We searched YouTube with the terms Diabetes, Diabetes type 2, Diabetes South Asians, Diabetes Punjabi and Diabetes Hindi to identify videos concerning type 2 diabetes. A team of health-care ...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2017.10.056

    authors: Leong AY,Sanghera R,Jhajj J,Desai N,Jammu BS,Makowsky MJ

    更新日期:2018-08-01 00:00:00

  • Hyperglycemia in Young Adults With Types 1 and 2 Diabetes Seen in the Emergency Department: A Health Records Review.

    abstract::Patients with diabetes who are in emerging adulthood, defined as the life stage between 18 and 29 years of age, have unique challenges in managing their illness and are at risk for acute complications and loss to follow up. This study's objective was to describe emergency department (ED) utilization because of hypergl...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2017.06.016

    authors: Yan JW,Hamelin AL,Gushulak KM,Van Aarsen K,Columbus MP,Stiell IG

    更新日期:2018-06-01 00:00:00

  • Impact of the Balanced School Day on Glycemic Control in Children with Type 1 Diabetes.

    abstract:OBJECTIVE:The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD becaus...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2016.07.005

    authors: Stein RI,Doulla M,Seabrook JA,Yau L,Hamilton N,Salvadori MI,Dworatzek PDN

    更新日期:2017-02-01 00:00:00

  • Short-Term Dietary Oatmeal Interventions in Adults With Type 2 Diabetes: A Forgotten Tool.

    abstract::Dietary modifications play a central role in the treatment of diabetes. Educating and empowering individuals to make better dietary choices is a challenging task. In this context, 1 potential dietetic approach to achieve better glycemic control in type 2 diabetes is often overlooked: the use of short-term dietary oatm...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2019.08.020

    authors: Storz MA,Iraci F

    更新日期:2020-06-01 00:00:00

  • Understanding the Experiences of East African Immigrant Women With Gestational Diabetes Mellitus.

    abstract:OBJECTIVES:East African (EA) women are a subpopulation who are at very high risk for gestational diabetes (GDM) and poor obstetric outcomes, but little is known about the care experiences of this understudied group. The objective of this study was to document the impact of a diagnosis of GDM and the perceptions of diab...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2018.01.013

    authors: Siad FM,Fang XY,Santana MJ,Butalia S,Hebert MA,Rabi DM

    更新日期:2018-12-01 00:00:00

  • Glucagon-like Peptide-1 Receptor Agonists: A Class Update for Treating Type 2 Diabetes.

    abstract::Current management options for treating type 2 diabetes are diverse. Many different classes of antidiabetes therapies are used in clinic, and several new candidates are in late-phase clinical trial. This therapeutic abundance is a windfall for patients because it facilitates individualized patient care. Evidence-based...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2017.08.242

    authors: Lovshin JA

    更新日期:2017-10-01 00:00:00

  • Insulin infusion therapy in critically ill patients.

    abstract::While dysglycemia (hyperglycemia, hypoglycemia and glucose variability) is clearly associated with increased mortality in critically ill patients, target range of blood glucose control remains controversial. Standardized insulin infusion protocols constitute the basis of treatment of these patients. The choice of prot...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2014.01.016

    authors: Boutin JM,Gauthier L

    更新日期:2014-04-01 00:00:00

  • Insights Into the Current Management of Older Adults With Type 2 Diabetes in the Ontario Primary Care Setting.

    abstract:OBJECTIVE:The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS:Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and we...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2017.03.003

    authors: Meneilly GS,Berard LD,Cheng AYY,Lin PJ,MacCallum L,Tsuyuki RT,Yale JF,Nasseri N,Richard JF,Goldin L,Langer A,Tan MK,Leiter LA

    更新日期:2018-02-01 00:00:00

  • Efficacy of Carbohydrate Supplementation Compared With Bolus Insulin Dose Reduction Around Exercise in Adults With Type 1 Diabetes: A Retrospective, Controlled Analysis.

    abstract:OBJECTIVES:Individuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by either pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting hypoglycemia, but it remains unclear whic...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2020.03.003

    authors: Eckstein ML,McCarthy O,Tripolt NJ,Müller A,Birnbaumer P,Pferschy PN,Hofmann P,Bracken RM,Sourij H,Moser O

    更新日期:2020-12-01 00:00:00

  • Group medical visits in primary care for patients with diabetes and low socioeconomic status: users' perspectives and lessons for practitioners.

    abstract:OBJECTIVE:This article describes a qualitative research study that examines the encounters by patients of low socioeconomic status with a group medical visit (GMV) program for individuals with or at risk for diabetes. The goal of this study was to generate insights that could be used to guide the development of an inne...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2014.03.012

    authors: Thompson C,Meeuwisse I,Dahlke R,Drummond N

    更新日期:2014-06-01 00:00:00

  • Diet, inflammation and prediabetes-impact of quality of diet.

    abstract::Low grade inflammation has been linked to risk of type 2 diabetes and atherosclerotic vascular diseases. Obesity and, in particular, abdominal obesity increase the risk of diabetes and atherosclerotic vascular diseases. One of the mechanisms could be low grade inflammation and vascular endothelial dysfunction. Permane...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2013.07.029

    authors: Uusitupa M,Schwab U

    更新日期:2013-10-01 00:00:00

  • Use patterns of antidiabetic regimens by patients with type 2 diabetes.

    abstract:OBJECTIVE:To describe the use patterns of metformin-based antidiabetic regimens in patients with type 2 diabetes and to identify predictors of initiating metformin monotherapy. METHODS:By using administrative databases from Alberta, Canada, we identified all metformin users ages 65 years and older between 1998 and 201...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2013.04.008

    authors: Abdelmoneim AS,Eurich DT,Gamble JM,Simpson SH

    更新日期:2013-12-01 00:00:00

  • Effects of Changing the Amount and Source of Dietary Carbohydrates on Symptoms and Dietary Satisfaction Over a 1-Year Period in Subjects with Type 2 Diabetes: Canadian Trial of Carbohydrates in Diabetes (CCD).

    abstract:OBJECTIVES:To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS:Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jcjd.2016.08.223

    authors: Wolever TM,Chiasson JL,Josse RG,Leiter LA,Maheux P,Rabasa-Lhoret R,Rodger NW,Ryan EA

    更新日期:2017-04-01 00:00:00

  • Alberta Healthy Living Program--a model for successful integration of chronic disease management services.

    abstract::The most common presentation of chronic disease is multimorbidity. Disease management strategies are similar across most chronic diseases. Given the prevalence of multimorbidity and the commonality in approaches, fragmented single disease management must be replaced with integrated care of the whole person. The Albert...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章

    doi:10.1016/j.jcjd.2013.04.001

    authors: Morrin L,Britten J,Davachi S,Knight H

    更新日期:2013-08-01 00:00:00

  • Diabetes and Frailty: Two Converging Conditions?

    abstract::Diabetes mellitus is a disabling, chronic cardiovascular and medical disease with a tremendous health, social and economic burden in our ageing communities. It has a prevalence of 10% to 30% in people older than 65 years of age, and more than half of all subjects with diabetes in the United States are older than 60 ye...

    journal_title:Canadian journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1016/j.jcjd.2015.09.004

    authors: Sinclair AJ,Rodriguez-Mañas L

    更新日期:2016-02-01 00:00:00