Abstract：
:To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moderate or low (high death-to-birth ratio), senescence offers significant protection against cancer by halting abnormal cell proliferation at early pre-diagnostic stages of tumor development. We also find that by the time tumors are typically detected, there is a high probability that telomerase is activated, even if the cell of origin was telomerase negative. Hence, the fact that most cancers are positive for telomerase is not necessarily an indication that cancer originated in a telomerase positive cell. Finally, we discuss how the population dynamics of cells can determine the outcomes of anti-telomerase cancer therapies, and provide guidelines on how the model could potentially be applied to develop clinically useful tools to predict the response to treatment by telomerase inhibitors in individual patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rodriguez-Brenes IA,Wodarz D,Komarova NLdoi
10.1038/srep17660subject
Has Abstractpub_date
2015-12-09 00:00:00pages
17660issn
2045-2322pii
srep17660journal_volume
5pub_type
杂志文章abstract：:The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42092
更新日期：2017-02-13 00:00:00
abstract：:Pseudomonas aeruginosa is a major threat for immune-compromised patients. Bacterial pneumonia can induce uncontrolled and massive neutrophil recruitment ultimately leading to acute respiratory distress syndrome and epithelium damage. Interleukin-22 plays a central role in the protection of the epithelium. In this stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11518-0
更新日期：2017-09-08 00:00:00
abstract：:Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66090-x
更新日期：2020-06-08 00:00:00
abstract：:The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the pres...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62195-5
更新日期：2020-03-30 00:00:00
abstract：:Efficient control of magnetism with electric means is a central issue of current spintronics research, which opens an opportunity to design integrated spintronic devices. However, recent well-studied methods are mostly based on electric-current injection, and they are inevitably accompanied by considerable energy loss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46009-x
更新日期：2019-07-02 00:00:00
abstract：:The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58698-w
更新日期：2020-02-04 00:00:00
abstract：:High abundance and widespread distribution of the archaeal phylum Bathyarchaeota in marine environment have been recognized recently, but knowledge about Bathyarchaeota in terrestrial settings and their correlation with environmental parameters is fairly limited. Here we reported the abundance of Bathyarchaeota member...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45028
更新日期：2017-03-21 00:00:00
abstract：:Viral upper respiratory tract infection (URTI) predisposes to bacterial pneumonia possibly by facilitating growth of bacteria such as Streptococcus pneumoniae colonising the nasopharynx. We investigated whether viral URTI is temporally associated with an increase in nasopharyngeal pneumococcal concentration. Episodes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29119-w
更新日期：2018-07-23 00:00:00
abstract：:The 2011 Tohoku earthquake drastically changed human activities in some regions of Fukushima Prefecture, Japan. The subsequent tsunami damage and radioactive pollution from the Fukushima Daiichi nuclear power plant resulted in the evacuation of humans, and abandonment of agricultural lands, allowing population expansi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47982-z
更新日期：2019-08-08 00:00:00
abstract：:Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69571-1
更新日期：2020-07-29 00:00:00
abstract：:Many organisms faced with seasonally fluctuating abiotic and biotic conditions respond by altering their phenotype to account for the demands of environmental changes. Here we discovered that newts, which switch seasonally between an aquatic and terrestrial lifestyle, grow a complex adhesive system on their tongue pad...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00674-y
更新日期：2017-04-21 00:00:00
abstract：:Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, in a context where even mice have been questioned as a valid model for these analysis, a systematic study evaluating the reproducibility of hu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41905
更新日期：2017-02-03 00:00:00
abstract：:Thermoelectric effects in magnetic tunnel junctions are promising to serve as the basis for logic devices or memories in a "green" information technology. However, up to now the readout contrast achieved with Seebeck effects was magnitudes smaller compared to the well-established tunnel magnetoresistance effect. Here,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08945
更新日期：2015-03-10 00:00:00
abstract：:We found a novel spontaneous mouse mutant with depigmentation in the ventral body, which we called White Spotting (WS) mouse. Genetic investigation revealed deletion of a > 1.2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135). We designated this mutant allele K...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13632
更新日期：2015-09-08 00:00:00
abstract：:Fibrocystic breast change (FBC) is extremely common and occurrs in 90% of women during their lives. The association between body composition and risk of breast cancer is well established. We hypothesized that the effect might exist during the development of FBC. Our aim was to examine the relationships of total lean m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27546-3
更新日期：2018-06-15 00:00:00
abstract：:Maize streak virus disease (MSVD), caused by Maize streak virus (MSV; genus Mastrevirus), is one of the most severe and widespread viral diseases that adversely reduces maize yield and threatens food security in Africa. An effective control and management of MSVD requires robust and sensitive diagnostic tests capable ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76612-2
更新日期：2020-11-12 00:00:00
abstract：:Accurate recording of large, earthquake-induced ground shaking is critical for our understanding of earthquake physics as well as seismic hazard assessment. Extremely large accelerations with the peak value of 3.2 times the gravity acceleration were recorded at seismic station WTMC located in northern South Island of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37716-y
更新日期：2019-02-04 00:00:00
abstract：:Radiation exposure during muscle development induces long-term decrements to skeletal muscle health, which contribute to reduced quality of life in childhood cancer survivors. Whether the effects of radiation on skeletal muscle are influenced by relevant physiological factors, such as obesity and exercise training rem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43204-8
更新日期：2019-04-30 00:00:00
abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45180-5
更新日期：2019-07-01 00:00:00
abstract：:Very little is known about how fimbriae of Bacteroidetes bacteria are assembled. To shed more light on this process, we solved the crystal structures of the shaft protein Mfa1, the regulatory protein Mfa2, and the tip protein Mfa3 from the periodontal pathogen Porphyromonas gingivalis. Together these build up part of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20067-z
更新日期：2018-01-29 00:00:00
abstract：:Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38837
更新日期：2017-03-13 00:00:00
abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00278-6
更新日期：2017-03-09 00:00:00
abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36058-z
更新日期：2018-12-05 00:00:00
abstract：:Tuberculosis treatment includes broad-spectrum antibiotics such as rifampicin, streptomycin and fluoroquinolones, which are also used against other pathogenic bacteria. We developed Drug Resistance Associated Genes database (DRAGdb), a manually curated repository of mutational data of drug resistance associated genes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65766-8
更新日期：2020-06-02 00:00:00
abstract：:Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence of associations of genetic variants (e.g. rs671 in ALDH2) with such risk factors in women - who drank little in these populations - provides ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18422
更新日期：2015-12-21 00:00:00
abstract：:Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39448-z
更新日期：2019-03-05 00:00:00
abstract：:Overexpression of hST3Gal1 leads to hypersialylation of cell-surface glycoconjugates, a cancer-associated condition that promotes cell growth, migration and invasion. Upregulation of this enzyme in ovarian cancer is linked to cancer progression and metastasis, contributing also to chemotherapy resistance. Strategies f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54384-8
更新日期：2019-11-29 00:00:00
abstract：:An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.1, 0.2, 0.3, 0.5% wt.% P) were melted in a melting furnace under 1200 °C and cast into metal mould, the hardness, strength and elongation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49441-1
更新日期：2019-09-16 00:00:00
abstract：:The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79893-9
更新日期：2021-01-12 00:00:00
abstract：:Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19415-w
更新日期：2018-01-18 00:00:00
