NF-κB Inhibition Resolves Cognitive Deficits in Experimental Type 2 Diabetes Mellitus through CREB and Glutamate/GABA Neurotransmitters Pathway.


:Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a large gap remains in understanding of the mechanisms and consequences of NF-κB activation in the central nervous system.In this study, we have evaluated the effects of NF-κB activation inhibitor on memory function, neurotransmitter levels changes and brain inflammatory cytokines in type-2 diabetic rats. BAY 11-7082 (BAY) was used as a pharmacological inhibitor of IκBα (inhibitor of kappa B alpha) phosphorylation to block NF-κB activation. Type-2 diabetic rats showed significant memory impairment at 15(th) week. Three weeks BAY treatment produced significant increase in Morris water maze test learning and memory performance. Diabetic animals also showed improved performance in passive avoidance and Y-maze test paradigm following treatment with NF-κB inhibitor BAY. BAY treatment did not show any significant effect on blood glucose and insulin levels. NF-κB inhibition significantly reduced neuroinflammation as evidenced by decrease in IL-6 and TNF-α levels. BAY treatment in diabetic rats also increased the phosphorylation of CREB which indicates that the NF-κB activation inhibitor engage a CREB regulated mechanism in-vivo. Moreover, BAY also reversed the alterations in brain glutamate and GABA levels in diabetic rats. These findings corroborate that NF-κB inhibition may be an effective treatment strategy in diabetes associated cognitive deficits.


Curr Neurovasc Res


Datusalia AK,Sharma SS




Has Abstract


2016-01-01 00:00:00














  • NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis.

    abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Okouchi M,Okayama N,Alexander JS,Aw TY

    更新日期:2006-11-01 00:00:00

  • Nifedipine inhibits the progression of an experimentally induced cerebral aneurysm in rats with associated down-regulation of NF-kappa B transcriptional activity.

    abstract::Cerebral aneurysm (CA) causes a life-threatening subarachnoid hemorrhage. However, no effective medical treatment to prevent the growth of CA is available. Nifedipine, a widely used calcium antagonist, was shown to improve endothelial function in various cardiovascular diseases. We examined whether nifedipine has a pr...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Aoki T,Kataoka H,Ishibashi R,Nozaki K,Hashimoto N

    更新日期:2008-02-01 00:00:00

  • Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia.

    abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RR

    更新日期:2012-08-01 00:00:00

  • Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex.

    abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

    更新日期:2016-01-01 00:00:00

  • Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain.

    abstract::Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Higashida T,Peng C,Li J,Dornbos D 3rd,Teng K,Li X,Kinni H,Guthikonda M,Ding Y

    更新日期:2011-02-01 00:00:00

  • Perinatal asphyxia in preterm neonates leads to serum changes in protein S-100 and neuron specific enolase.

    abstract::In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Giuseppe D,Sergio C,Pasqua B,Giovanni LV,Salvatore C,Frigiola A,Petra H,Maurizio A

    更新日期:2009-05-01 00:00:00

  • A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms.

    abstract::Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Lin Y,Yu H,Song W,Zhang Y,Zhang C,Zhu Y,Pang Q,Hui R,Chen J

    更新日期:2014-01-01 00:00:00

  • TRPA1 and TRPM8 Receptors May Promote Local Vasodilation that Aggravates Oxaliplatin-Induced Peripheral Neuropathy Amenable to 17β-Estradiol Treatment.

    abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

    更新日期:2016-01-01 00:00:00

  • Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis.

    abstract::Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence of antigens or micro...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Maestroni GJ

    更新日期:2005-04-01 00:00:00

  • Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

    abstract::Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Chong ZZ,Li F,Maiese K

    更新日期:2005-01-01 00:00:00

  • Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study.

    abstract:BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Rosenbaum MD,Heiferman DM,Raslan OA,Martin B,Dominguez JF,de la Peña PM,Ashley WW,Rosenblum JD,Germanwala AV

    更新日期:2019-01-01 00:00:00

  • Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke.

    abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

    更新日期:2009-08-01 00:00:00

  • An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset.

    abstract::This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara H

    更新日期:2015-01-01 00:00:00

  • Using endogenous neural stem cells to enhance recovery from ischemic brain injury.

    abstract::The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation of embryonic stem cells ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Leker RR,McKay RD

    更新日期:2004-12-01 00:00:00

  • High Serum Alkaline Phosphatase Levels in Relation to Multi-Cerebral Microbleeds in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease.

    abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Liu J,Wang D,Li J,Xiong Y,Liu B,Wei C,Wu S,Liu M

    更新日期:2016-01-01 00:00:00

  • Deep brain stimulation for Stroke: Continuous stimulation of the pedunculopontine tegmental nucleus has no impact on skilled walking in rats after photothrombotic stroke.

    abstract:BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri F

    更新日期:2020-12-01 00:00:00

  • Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.

    abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Qu X,Shi J,Cao Y,Zhang M,Xu J

    更新日期:2018-01-01 00:00:00

  • Biological Function and Mechanism of Bone Marrow Mesenchymal Stem Cells-packed Poly (3,4-ethylenedioxythiophene) (PEDOT) Scaffolds for Peripheral Nerve Injury: The Involvement of miR-21-Notch Signaling Pathway.

    abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Wu W,Zhang S,Chen Y,Liu H

    更新日期:2017-01-01 00:00:00

  • Elevated Serum Homocysteine Associated with Distal Type of Single Small Subcortical Infarction.

    abstract:OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Liu C,Gao Y,Song B,Wang Y,Pei L,Li S,Xu Y,Li Y

    更新日期:2020-10-29 00:00:00

  • Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.

    abstract:BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Caprio MG,Marr K,Gandhi S,Jakimovski D,Hagemeier J,Weinstock-Guttman B,Zivadinov R,Mancini M

    更新日期:2017-01-01 00:00:00

  • The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways.

    abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Chong ZZ,Lin SH,Li F,Maiese K

    更新日期:2005-10-01 00:00:00

  • Multiple sclerosis -- a coordinated immune attack across the blood brain barrier.

    abstract::Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Hemmer B,Cepok S,Zhou D,Sommer N

    更新日期:2004-04-01 00:00:00

  • Dexmedetomidine Pretreatment Improves Lipopolysaccharide-induced Iron Homeostasis Disorder in Aged Mice.

    abstract:BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Guo F,Kang J,Tan J,Wang Y,Jia L,Xu H

    更新日期:2020-01-01 00:00:00

  • Doppler haemodynamics of cerebral venous return.

    abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Menegatti E,Zamboni P

    更新日期:2008-11-01 00:00:00

  • Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain.

    abstract::This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Pluta R

    更新日期:2007-05-01 00:00:00

  • Intracranial venous haemodynamics in multiple sclerosis.

    abstract::In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Zamboni P,Menegatti E,Bartolomei I,Galeotti R,Malagoni AM,Tacconi G,Salvi F

    更新日期:2007-11-01 00:00:00

  • Association Between Preoperative Midline Shift Growing Rate and Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction.

    abstract:BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Yuan R,Wu S,Cheng Y,Ye K,Hao Z,Zhang S,Liu Y,Liu M

    更新日期:2020-01-01 00:00:00

  • Association of Non-Traditional Lipid Parameters with Hemorrhagic Transformation and Clinical Outcome After Thrombolysis in Ischemic Stroke Patients.

    abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

    更新日期:2021-01-01 00:00:00

  • Prolactin and blood-brain barrier permeability.

    abstract::The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

    更新日期:2013-11-01 00:00:00

  • Recombinant human growth hormone in abstinent androgenic-anabolic steroid use: psychological, endocrine and trophic factor effects.

    abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,随机对照试验


    authors: Graham MR,Davies B,Kicman A,Cowan D,Hullin D,Baker JS

    更新日期:2007-02-01 00:00:00