NF-κB Inhibition Resolves Cognitive Deficits in Experimental Type 2 Diabetes Mellitus through CREB and Glutamate/GABA Neurotransmitters Pathway.


:Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a large gap remains in understanding of the mechanisms and consequences of NF-κB activation in the central nervous system.In this study, we have evaluated the effects of NF-κB activation inhibitor on memory function, neurotransmitter levels changes and brain inflammatory cytokines in type-2 diabetic rats. BAY 11-7082 (BAY) was used as a pharmacological inhibitor of IκBα (inhibitor of kappa B alpha) phosphorylation to block NF-κB activation. Type-2 diabetic rats showed significant memory impairment at 15(th) week. Three weeks BAY treatment produced significant increase in Morris water maze test learning and memory performance. Diabetic animals also showed improved performance in passive avoidance and Y-maze test paradigm following treatment with NF-κB inhibitor BAY. BAY treatment did not show any significant effect on blood glucose and insulin levels. NF-κB inhibition significantly reduced neuroinflammation as evidenced by decrease in IL-6 and TNF-α levels. BAY treatment in diabetic rats also increased the phosphorylation of CREB which indicates that the NF-κB activation inhibitor engage a CREB regulated mechanism in-vivo. Moreover, BAY also reversed the alterations in brain glutamate and GABA levels in diabetic rats. These findings corroborate that NF-κB inhibition may be an effective treatment strategy in diabetes associated cognitive deficits.


Curr Neurovasc Res


Datusalia AK,Sharma SS




Has Abstract


2016-01-01 00:00:00














  • Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.

    abstract:BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Caprio MG,Marr K,Gandhi S,Jakimovski D,Hagemeier J,Weinstock-Guttman B,Zivadinov R,Mancini M

    更新日期:2017-01-01 00:00:00

  • Identification of target antigens of antiendothelial cell antibodies against human brain microvascular endothelial cells in healthy subjects.

    abstract::Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In the present study, we evaluated AECAs against human brain microvascular endotheli...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Kimura A,Sakurai T,Yoshikura N,Koumura A,Hayashi Y,Ohtaki H,Chousa M,Seishima M,Inuzuka T

    更新日期:2015-01-01 00:00:00

  • Early timing of endovascular treatment for aneurysmal subarachnoid hemorrhage achieves improved outcomes.

    abstract::Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Qian Z,Peng T,Liu A,Li Y,Jiang C,Yang H,Wu J,Kang H,Wu Z

    更新日期:2014-02-01 00:00:00

  • Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain.

    abstract::Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Higashida T,Peng C,Li J,Dornbos D 3rd,Teng K,Li X,Kinni H,Guthikonda M,Ding Y

    更新日期:2011-02-01 00:00:00

  • The multiple facets of hematopoietic stem cells.

    abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Chan RJ,Yoder MC

    更新日期:2004-07-01 00:00:00

  • Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex.

    abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

    更新日期:2016-01-01 00:00:00

  • Membrane insertion of new AMPA receptors and LTP induced by glycine is prevented by blocking NR2A-containing NMDA receptors in the rat visual cortex in vitro.

    abstract::N-methyl-D-aspartate receptors (NMDA-Rs) activation has been implicated in various forms of synaptic plasticity depending on the receptor subtypes involved. However, the contribution of NR2A and NR2B subunits in glycine-induced long-term potentiation (LTP) of miniature excitatory postsynaptic currents (mEPSCs) in laye...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Li YH,Wang J

    更新日期:2013-02-01 00:00:00

  • Human mesenchymal stem cells increases expression of α-tubulin and angiopoietin 1 and 2 in focal cerebral ischemia and reperfusion.

    abstract::Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Ma XL,Liu KD,Li FC,Jiang XM,Jiang L,Li HL

    更新日期:2013-05-01 00:00:00

  • Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia.

    abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RR

    更新日期:2012-08-01 00:00:00

  • Biological Function and Mechanism of Bone Marrow Mesenchymal Stem Cells-packed Poly (3,4-ethylenedioxythiophene) (PEDOT) Scaffolds for Peripheral Nerve Injury: The Involvement of miR-21-Notch Signaling Pathway.

    abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Wu W,Zhang S,Chen Y,Liu H

    更新日期:2017-01-01 00:00:00

  • NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis.

    abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Okouchi M,Okayama N,Alexander JS,Aw TY

    更新日期:2006-11-01 00:00:00

  • Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.

    abstract::This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Carvalho C,Santos MS,Baldeiras I,Oliveira CR,Seiça R,Moreira PI

    更新日期:2010-11-01 00:00:00

  • Fluoxetine enhances Brain Derived Neurotropic Factor Serum Concentration and Cognition in Patients with Vascular Dementia.

    abstract::Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Liu X,Zhang J,Sun D,Fan Y,Zhou H,Fu B

    更新日期:2013-08-19 00:00:00

  • Platelet-derived Growth Factor Receptor-beta is Differentially Regulated in Primary Mouse Pericytes and Brain Slices.

    abstract::Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Hutter-Schmid B,Humpel C

    更新日期:2016-01-01 00:00:00

  • Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke.

    abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

    更新日期:2009-08-01 00:00:00

  • Deep brain stimulation for Stroke: Continuous stimulation of the pedunculopontine tegmental nucleus has no impact on skilled walking in rats after photothrombotic stroke.

    abstract:BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri F

    更新日期:2020-12-01 00:00:00

  • An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset.

    abstract::This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara H

    更新日期:2015-01-01 00:00:00

  • TRPA1 and TRPM8 Receptors May Promote Local Vasodilation that Aggravates Oxaliplatin-Induced Peripheral Neuropathy Amenable to 17β-Estradiol Treatment.

    abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

    更新日期:2016-01-01 00:00:00

  • Higher Levels of Dynamin-related Protein 1 are Associated with Reduced Radiation Sensitivity of Glioblastoma Cells.

    abstract:BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Cheng WY,Chow KC,Chiao MT,Yang YC,Shen CC

    更新日期:2020-01-01 00:00:00

  • Prolactin and blood-brain barrier permeability.

    abstract::The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

    更新日期:2013-11-01 00:00:00

  • Using endogenous neural stem cells to enhance recovery from ischemic brain injury.

    abstract::The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation of embryonic stem cells ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Leker RR,McKay RD

    更新日期:2004-12-01 00:00:00

  • Association Between Preoperative Midline Shift Growing Rate and Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction.

    abstract:BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Yuan R,Wu S,Cheng Y,Ye K,Hao Z,Zhang S,Liu Y,Liu M

    更新日期:2020-01-01 00:00:00

  • Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality.

    abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Anne M,Juha K,Timo M,Mikko T,Olli V,Kyösti S,Heikki H,Vilho M

    更新日期:2007-08-01 00:00:00

  • Association of Non-Traditional Lipid Parameters with Hemorrhagic Transformation and Clinical Outcome After Thrombolysis in Ischemic Stroke Patients.

    abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

    更新日期:2021-01-01 00:00:00

  • Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain.

    abstract::This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Pluta R

    更新日期:2007-05-01 00:00:00

  • Doppler haemodynamics of cerebral venous return.

    abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Menegatti E,Zamboni P

    更新日期:2008-11-01 00:00:00

  • Remote Ischemic Conditioning Improves Cognitive Function During Cerebral Vascular Injury Through the Induction of Autophagy.

    abstract:BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Wang H,Zhang Q,Xu Y,Bian H,Si C,Yan Z,Zhu M

    更新日期:2017-01-01 00:00:00

  • Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

    abstract::Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审


    authors: Chong ZZ,Li F,Maiese K

    更新日期:2005-01-01 00:00:00

  • The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways.

    abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...

    journal_title:Current neurovascular research

    pub_type: 杂志文章


    authors: Chong ZZ,Lin SH,Li F,Maiese K

    更新日期:2005-10-01 00:00:00

  • Recombinant human growth hormone in abstinent androgenic-anabolic steroid use: psychological, endocrine and trophic factor effects.

    abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,随机对照试验


    authors: Graham MR,Davies B,Kicman A,Cowan D,Hullin D,Baker JS

    更新日期:2007-02-01 00:00:00