Abstract:
BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circulation, such as with CAS, increase compensatory flow demands via the Circle of Willis (COW) and may induce similar stress at the basilar apex. OBJECTIVE:We present a series of nine unruptured basilar apex aneurysms (BAA) with CAS and a comparative radiographic analysis to BAA without CAS. METHODS:Twenty-three patients with BAA were retrospectively identified using records from 2011 to 2016. CAS by North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria, morphology of BAA, competency of COW, and anatomic relationships within the posterior circulation were examined independently by a neuroradiologist using angiographic imaging. RESULTS:Nine (39%) of the twenty-three BAA patients had CAS, with six having stenosis ≥50%. Four (67%) of the patients with ≥50% CAS demonstrated aneurysm flow angles contralateral to the side with highest CAS. Additionally, the angle between the basilar artery (BA) trajectory and aneurysm neck was observed to be smaller in patients with ≥50% CAS (61 vs 74 degrees). No significant differences in COW patency, posterior circulation morphology, and degree of stenosis were observed. CONCLUSION:Changes in the cervical carotid arteries may lead to blood flow alterations in the posterior circulation that increase the propensity for BAA formation. Posterior circulation imaging can be considered in CAS patients to screen for BAA.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Rosenbaum MD,Heiferman DM,Raslan OA,Martin B,Dominguez JF,de la Peña PM,Ashley WW,Rosenblum JD,Germanwala AVdoi
10.2174/1567202616666190129150403subject
Has Abstractpub_date
2019-01-01 00:00:00pages
12-18issue
1eissn
1567-2026issn
1875-5739pii
CNR-EPUB-96198journal_volume
16pub_type
杂志文章abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720206778792876
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666171005122925
更新日期:2017-01-01 00:00:00
abstract::Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202052773508
更新日期:2005-01-01 00:00:00
abstract::No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774962683
更新日期:2005-12-01 00:00:00
abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788970036
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200217105109
更新日期:2020-01-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362324
更新日期:2004-07-01 00:00:00
abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720212801619018
更新日期:2012-08-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043480152
更新日期:2004-04-01 00:00:00
abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160817095623
更新日期:2016-01-01 00:00:00
abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207781387169
更新日期:2007-08-01 00:00:00
abstract::In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angio...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362072
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200207125552
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180326101524
更新日期:2018-01-01 00:00:00
abstract::Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202611310020003
更新日期:2013-05-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150102124703
更新日期:2015-01-01 00:00:00
abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774322584
更新日期:2005-10-01 00:00:00
abstract::This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720210793180765
更新日期:2010-11-01 00:00:00
abstract::Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In the present study, we evaluated AECAs against human brain microvascular endotheli...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150107161847
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666170718095203
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666181204122457
更新日期:2018-01-01 00:00:00
abstract::Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666151030104810
更新日期:2016-01-01 00:00:00
abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666161123112832
更新日期:2017-01-01 00:00:00
abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160601144254
更新日期:2016-01-01 00:00:00
abstract::HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell struc...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208784310222
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666201029145824
更新日期:2020-10-29 00:00:00
abstract:BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200623123638
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666170619081419
更新日期:2017-01-01 00:00:00
abstract::The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/15672026113109990025
更新日期:2013-11-01 00:00:00
abstract::Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720211794520251
更新日期:2011-02-01 00:00:00