Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.

abstract：:Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...

journal_title：Current neurovascular research

authors： Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RR

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

journal_title：Current neurovascular research

authors： Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

journal_title：Current neurovascular research

authors： Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

更新日期：2016-01-01 00:00:00

abstract：:This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...

journal_title：Current neurovascular research

authors： Pluta R

更新日期：2007-05-01 00:00:00

abstract：:In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...

journal_title：Current neurovascular research

authors： Giuseppe D,Sergio C,Pasqua B,Giovanni LV,Salvatore C,Frigiola A,Petra H,Maurizio A

更新日期：2009-05-01 00:00:00

abstract：:Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...

journal_title：Current neurovascular research

authors： Qian Z,Peng T,Liu A,Li Y,Jiang C,Yang H,Wu J,Kang H,Wu Z

更新日期：2014-02-01 00:00:00

abstract：:Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

journal_title：Current neurovascular research

authors： Wu W,Zhang S,Chen Y,Liu H

更新日期：2017-01-01 00:00:00

abstract：:Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the blood vessels starts with prominent hemorrhage and generation of inflammation. Fu...

journal_title：Current neurovascular research

authors： Graumann U,Ritz MF,Hausmann O

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

journal_title：Current neurovascular research

authors： Qu X,Shi J,Cao Y,Zhang M,Xu J

更新日期：2018-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...

journal_title：Current neurovascular research

authors： Chan RJ,Yoder MC

更新日期：2004-07-01 00:00:00

abstract：:HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell struc...

journal_title：Current neurovascular research

authors： Hu Z,Li T

更新日期：2008-05-01 00:00:00

abstract：:Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...

journal_title：Current neurovascular research

authors： Lin Y,Yu H,Song W,Zhang Y,Zhang C,Zhu Y,Pang Q,Hui R,Chen J

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...

journal_title：Current neurovascular research

authors： Chong ZZ,Li F,Maiese K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors fo...

journal_title：Current neurovascular research

authors： Xin J,Huang X,Pan X,Lin L,Sun M,Liu C,Ye Q

更新日期：2019-01-01 00:00:00

abstract：:The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

journal_title：Current neurovascular research

authors： Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

更新日期：2013-11-01 00:00:00

abstract：:Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...

journal_title：Current neurovascular research

authors： Okouchi M,Okayama N,Alexander JS,Aw TY

更新日期：2006-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...

journal_title：Current neurovascular research

authors： Hemmer B,Cepok S,Zhou D,Sommer N

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...

journal_title：Current neurovascular research

authors： Liu C,Gao Y,Song B,Wang Y,Pei L,Li S,Xu Y,Li Y

更新日期：2020-10-29 00:00:00

abstract：:Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...

journal_title：Current neurovascular research

authors： Liu J,Wang D,Li J,Xiong Y,Liu B,Wei C,Wu S,Liu M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...

journal_title：Current neurovascular research

authors： Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri F

更新日期：2020-12-01 00:00:00

abstract：:No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...

journal_title：Current neurovascular research

authors： Chong ZZ,Li F,Maiese K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...

journal_title：Current neurovascular research

authors： Schulz VC,de Magalhaes PSC,Carneiro CC,da Silva JIT,Silva VN,Guesser VV,Safanelli J,Diegoli H,Liberato RB,Lopes CCC,de Souza A,de França PHC,Conforto AB,Cabral NL

更新日期：2020-01-01 00:00:00

abstract：:A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...

journal_title：Current neurovascular research

authors： Anne M,Juha K,Timo M,Mikko T,Olli V,Kyösti S,Heikki H,Vilho M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...

journal_title：Current neurovascular research

authors： Wang H,Zhang Q,Xu Y,Bian H,Si C,Yan Z,Zhu M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...

journal_title：Current neurovascular research

authors： Guo F,Kang J,Tan J,Wang Y,Jia L,Xu H

更新日期：2020-01-01 00:00:00

abstract：:Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...

journal_title：Current neurovascular research

authors： Ma XL,Liu KD,Li FC,Jiang XM,Jiang L,Li HL

更新日期：2013-05-01 00:00:00

abstract：:The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation of embryonic stem cells ...

journal_title：Current neurovascular research

authors： Leker RR,McKay RD

更新日期：2004-12-01 00:00:00

abstract：:Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence of antigens or micro...

journal_title：Current neurovascular research

authors： Maestroni GJ

更新日期：2005-04-01 00:00:00

abstract：:Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

journal_title：Current neurovascular research

authors： Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

更新日期：2016-01-01 00:00:00

abstract：:Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

journal_title：Current neurovascular research

authors： Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

更新日期：2009-08-01 00:00:00