Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain.

abstract：:Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a...

journal_title：Current neurovascular research

authors： Datusalia AK,Sharma SS

更新日期：2016-01-01 00:00:00

abstract：:Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the blood vessels starts with prominent hemorrhage and generation of inflammation. Fu...

journal_title：Current neurovascular research

authors： Graumann U,Ritz MF,Hausmann O

更新日期：2011-11-01 00:00:00

abstract：:Cerebral aneurysm (CA) causes a life-threatening subarachnoid hemorrhage. However, no effective medical treatment to prevent the growth of CA is available. Nifedipine, a widely used calcium antagonist, was shown to improve endothelial function in various cardiovascular diseases. We examined whether nifedipine has a pr...

journal_title：Current neurovascular research

authors： Aoki T,Kataoka H,Ishibashi R,Nozaki K,Hashimoto N

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...

journal_title：Current neurovascular research

authors： Yuan R,Wu S,Cheng Y,Ye K,Hao Z,Zhang S,Liu Y,Liu M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...

journal_title：Current neurovascular research

authors： Rosenbaum MD,Heiferman DM,Raslan OA,Martin B,Dominguez JF,de la Peña PM,Ashley WW,Rosenblum JD,Germanwala AV

更新日期：2019-01-01 00:00:00

abstract：:Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...

journal_title：Current neurovascular research

authors： Lin Y,Yu H,Song W,Zhang Y,Zhang C,Zhu Y,Pang Q,Hui R,Chen J

更新日期：2014-01-01 00:00:00

abstract：:Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

journal_title：Current neurovascular research

authors： Wu W,Zhang S,Chen Y,Liu H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

journal_title：Current neurovascular research

authors： Qu X,Shi J,Cao Y,Zhang M,Xu J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors fo...

journal_title：Current neurovascular research

authors： Xin J,Huang X,Pan X,Lin L,Sun M,Liu C,Ye Q

更新日期：2019-01-01 00:00:00

abstract：:Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...

journal_title：Current neurovascular research

authors： Hutter-Schmid B,Humpel C

更新日期：2016-01-01 00:00:00

abstract：:Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

journal_title：Current neurovascular research

authors： Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

更新日期：2016-01-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...

journal_title：Current neurovascular research

authors： Liu X,Zhang J,Sun D,Fan Y,Zhou H,Fu B

更新日期：2013-08-19 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...

journal_title：Current neurovascular research

authors： Liu C,Gao Y,Song B,Wang Y,Pei L,Li S,Xu Y,Li Y

更新日期：2020-10-29 00:00:00

abstract：:Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...

journal_title：Current neurovascular research

authors： Menegatti E,Zamboni P

更新日期：2008-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...

journal_title：Current neurovascular research

authors： Hemmer B,Cepok S,Zhou D,Sommer N

更新日期：2004-04-01 00:00:00

abstract：:No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...

journal_title：Current neurovascular research

authors： Chong ZZ,Li F,Maiese K

更新日期：2005-12-01 00:00:00

abstract：:Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In the present study, we evaluated AECAs against human brain microvascular endotheli...

journal_title：Current neurovascular research

authors： Kimura A,Sakurai T,Yoshikura N,Koumura A,Hayashi Y,Ohtaki H,Chousa M,Seishima M,Inuzuka T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...

journal_title：Current neurovascular research

authors： Song Q,Li Y,Wang Y,Wei C,Liu J,Liu M

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

journal_title：Current neurovascular research

authors： Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...

journal_title：Current neurovascular research

authors： Wang H,Zhang Q,Xu Y,Bian H,Si C,Yan Z,Zhu M

更新日期：2017-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

journal_title：Current neurovascular research

authors： Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

更新日期：2016-01-01 00:00:00

abstract：:This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...

journal_title：Current neurovascular research

authors： Carvalho C,Santos MS,Baldeiras I,Oliveira CR,Seiça R,Moreira PI

更新日期：2010-11-01 00:00:00

abstract：:Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...

journal_title：Current neurovascular research

authors： Higashida T,Peng C,Li J,Dornbos D 3rd,Teng K,Li X,Kinni H,Guthikonda M,Ding Y

更新日期：2011-02-01 00:00:00

abstract：:A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...

journal_title：Current neurovascular research

authors： Anne M,Juha K,Timo M,Mikko T,Olli V,Kyösti S,Heikki H,Vilho M

更新日期：2007-08-01 00:00:00

abstract：:In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...

journal_title：Current neurovascular research

authors： Zamboni P,Menegatti E,Bartolomei I,Galeotti R,Malagoni AM,Tacconi G,Salvi F

更新日期：2007-11-01 00:00:00

abstract：:Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...

journal_title：Current neurovascular research

authors： Ma XL,Liu KD,Li FC,Jiang XM,Jiang L,Li HL

更新日期：2013-05-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDA-Rs) activation has been implicated in various forms of synaptic plasticity depending on the receptor subtypes involved. However, the contribution of NR2A and NR2B subunits in glycine-induced long-term potentiation (LTP) of miniature excitatory postsynaptic currents (mEPSCs) in laye...

journal_title：Current neurovascular research

authors： Li YH,Wang J

更新日期：2013-02-01 00:00:00

abstract：:In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...

journal_title：Current neurovascular research

authors： Giuseppe D,Sergio C,Pasqua B,Giovanni LV,Salvatore C,Frigiola A,Petra H,Maurizio A

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...

journal_title：Current neurovascular research

authors： Guo F,Kang J,Tan J,Wang Y,Jia L,Xu H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...

journal_title：Current neurovascular research

authors： Golab-Janowska M,Paczkowska E,Machalinski B,Meller A,Kotlega D,Safranow K,Wankowicz P,Nowacki P

更新日期：2018-01-01 00:00:00