Abstract:
BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality in AIS patients. METHODS:447 AIS patients treated with IVT between May 2010 and May 2017 were enrolled. WBC counts and CRP were measured within 24 hours after IVT. The main outcomes included poor functional outcomes (modified Rankin score ≥3) at 3 months and 3-month all-cause mortality. RESULTS:High WBC counts were associated with poor functional outcomes (adjusted OR (odds ratio) 4.48; 95% CI (confidence interval) 2.00-10.03; P-trend<0.001) and with all-cause mortality (adjusted HR (hazard ratio) 2.19; 95% CI 1.07-4.49; P-trend=0.018). In addition, high CRP levels were associated with poor functional outcomes (adjusted OR 4.95; 95% CI 1.39-17.65; Ptrend= 0.002). However, no significant association between high CRP levels and all-cause mortality was observed (adjusted HR 2.61; 95% CI 0.80-8.47; P-trend=0.138). CONCLUSION:Our analysis indicated that elevated WBC counts and CRP levels after IVT can independently predict poor outcome among AIS patients.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Qu X,Shi J,Cao Y,Zhang M,Xu Jdoi
10.2174/1567202615666180326101524subject
Has Abstractpub_date
2018-01-01 00:00:00pages
10-17issue
1eissn
1567-2026issn
1875-5739pii
CNR-EPUB-89274journal_volume
15pub_type
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abstract::In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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