Abstract:
:In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences in PDV, characterized by negative values (16.2+/-1 cm/sec in controls vs. -1.3 +/-2.6 cm/sec in MS, respectively, p<0.0001). Consequently, RI was dramatically increased in the MS group, affecting impedance of cerebral venous drainage (0.48+/-0.04 in controls vs. 1.1 +/-0.08 in MS, respectively p<0.0001). Therefore, the detection of reflux directed toward the subcortical grey matter was significantly associated to highest disability scores (p < 0.0001). Our study of MS patients demonstrated significant haemodynamic alterations detected in veins anatomically related to plaque disposition. Our findings should contribute towards understanding the role of altered venous flow and tissue drainage in the MS inflammatory chain, as well as in the neurodegenerative process.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Zamboni P,Menegatti E,Bartolomei I,Galeotti R,Malagoni AM,Tacconi G,Salvi Fdoi
10.2174/156720207782446298subject
Has Abstractpub_date
2007-11-01 00:00:00pages
252-8issue
4eissn
1567-2026issn
1875-5739journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors fo...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666190227202638
更新日期:2019-01-01 00:00:00
abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208786413442
更新日期:2008-11-01 00:00:00
abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160817095623
更新日期:2016-01-01 00:00:00
abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666161123112832
更新日期:2017-01-01 00:00:00
abstract::Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160219120411
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180611120546
更新日期:2018-01-01 00:00:00
abstract::Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202611310020003
更新日期:2013-05-01 00:00:00
abstract::N-methyl-D-aspartate receptors (NMDA-Rs) activation has been implicated in various forms of synaptic plasticity depending on the receptor subtypes involved. However, the contribution of NR2A and NR2B subunits in glycine-induced long-term potentiation (LTP) of miniature excitatory postsynaptic currents (mEPSCs) in laye...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720213804805927
更新日期:2013-02-01 00:00:00
abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207781387169
更新日期:2007-08-01 00:00:00
abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774322584
更新日期:2005-10-01 00:00:00
abstract::Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202611666140912114450
更新日期:2014-01-01 00:00:00
abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720212801619018
更新日期:2012-08-01 00:00:00
abstract::Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202610666131210104606
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200207125552
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666201201141046
更新日期:2020-12-01 00:00:00
abstract::The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/15672026113109990025
更新日期:2013-11-01 00:00:00
abstract::Increased homocysteine (Hcy) levels contribute to a variety of cardiovascular and cerebrovascular diseases including stroke and Alzheimer's disease. Recent data has shown that elevated levels of Hcy can lead to the blood-brain barrier (BBB) dysfunction and activation. However, the mechanism for Hcy-mediated dysfunctio...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720210792231787
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200521083132
更新日期:2020-01-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150102124703
更新日期:2015-01-01 00:00:00
abstract::Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666151030104810
更新日期:2016-01-01 00:00:00
abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...
journal_title:Current neurovascular research
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720207779940699
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666171005122925
更新日期:2017-01-01 00:00:00
abstract::HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell struc...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208784310222
更新日期:2008-05-01 00:00:00
abstract::This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720210793180765
更新日期:2010-11-01 00:00:00
abstract::Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence of antigens or micro...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202053586776
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617999210101223129
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180326101524
更新日期:2018-01-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362324
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666181204122457
更新日期:2018-01-01 00:00:00
abstract::In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788185614
更新日期:2009-05-01 00:00:00