Necessity for re-vascularization after spinal cord injury and the search for potential therapeutic options.

abstract：:This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...

journal_title：Current neurovascular research

authors： Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara H

更新日期：2015-01-01 00:00:00

abstract：:Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...

journal_title：Current neurovascular research

authors： Liu J,Wang D,Li J,Xiong Y,Liu B,Wei C,Wu S,Liu M

更新日期：2016-01-01 00:00:00

abstract：:Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

journal_title：Current neurovascular research

authors： Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

更新日期：2009-08-01 00:00:00

abstract：:Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...

journal_title：Current neurovascular research

authors： Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RR

更新日期：2012-08-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...

journal_title：Current neurovascular research

authors： Liu X,Zhang J,Sun D,Fan Y,Zhou H,Fu B

更新日期：2013-08-19 00:00:00

abstract：:A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...

journal_title：Current neurovascular research

authors： Anne M,Juha K,Timo M,Mikko T,Olli V,Kyösti S,Heikki H,Vilho M

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...

journal_title：Current neurovascular research

authors： Golab-Janowska M,Paczkowska E,Machalinski B,Meller A,Kotlega D,Safranow K,Wankowicz P,Nowacki P

更新日期：2018-01-01 00:00:00

abstract：:Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...

journal_title：Current neurovascular research

authors： Qian Z,Peng T,Liu A,Li Y,Jiang C,Yang H,Wu J,Kang H,Wu Z

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...

journal_title：Current neurovascular research

authors： Song Q,Li Y,Wang Y,Wei C,Liu J,Liu M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...

journal_title：Current neurovascular research

authors： Guo F,Kang J,Tan J,Wang Y,Jia L,Xu H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

journal_title：Current neurovascular research

authors： Qu X,Shi J,Cao Y,Zhang M,Xu J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...

journal_title：Current neurovascular research

authors： Schulz VC,de Magalhaes PSC,Carneiro CC,da Silva JIT,Silva VN,Guesser VV,Safanelli J,Diegoli H,Liberato RB,Lopes CCC,de Souza A,de França PHC,Conforto AB,Cabral NL

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...

journal_title：Current neurovascular research

authors： Chong ZZ,Li F,Maiese K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...

journal_title：Current neurovascular research

authors： Yuan R,Wu S,Cheng Y,Ye K,Hao Z,Zhang S,Liu Y,Liu M

更新日期：2020-01-01 00:00:00

abstract：:Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a...

journal_title：Current neurovascular research

authors： Datusalia AK,Sharma SS

更新日期：2016-01-01 00:00:00

abstract：:Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence of antigens or micro...

journal_title：Current neurovascular research

authors： Maestroni GJ

更新日期：2005-04-01 00:00:00

abstract：:Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

journal_title：Current neurovascular research

authors： Wu W,Zhang S,Chen Y,Liu H

更新日期：2017-01-01 00:00:00

abstract：:This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...

journal_title：Current neurovascular research

authors： Carvalho C,Santos MS,Baldeiras I,Oliveira CR,Seiça R,Moreira PI

更新日期：2010-11-01 00:00:00

abstract：:The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

journal_title：Current neurovascular research

authors： Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

更新日期：2013-11-01 00:00:00

abstract：:Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...

journal_title：Current neurovascular research

authors： Higashida T,Peng C,Li J,Dornbos D 3rd,Teng K,Li X,Kinni H,Guthikonda M,Ding Y

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...

journal_title：Current neurovascular research

authors： Cheng WY,Chow KC,Chiao MT,Yang YC,Shen CC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...

journal_title：Current neurovascular research

authors： Rosenbaum MD,Heiferman DM,Raslan OA,Martin B,Dominguez JF,de la Peña PM,Ashley WW,Rosenblum JD,Germanwala AV

更新日期：2019-01-01 00:00:00

abstract：:In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angio...

journal_title：Current neurovascular research

authors： Sakamaki K

更新日期：2004-10-01 00:00:00

abstract：:Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...

journal_title：Current neurovascular research

authors： Hutter-Schmid B,Humpel C

更新日期：2016-01-01 00:00:00

abstract：:Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

journal_title：Current neurovascular research

authors： Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

更新日期：2016-01-01 00:00:00

abstract：:Increased homocysteine (Hcy) levels contribute to a variety of cardiovascular and cerebrovascular diseases including stroke and Alzheimer's disease. Recent data has shown that elevated levels of Hcy can lead to the blood-brain barrier (BBB) dysfunction and activation. However, the mechanism for Hcy-mediated dysfunctio...

journal_title：Current neurovascular research

authors： Hohsfield LA,Humpel C

更新日期：2010-08-01 00:00:00

abstract：:Cerebral aneurysm (CA) causes a life-threatening subarachnoid hemorrhage. However, no effective medical treatment to prevent the growth of CA is available. Nifedipine, a widely used calcium antagonist, was shown to improve endothelial function in various cardiovascular diseases. We examined whether nifedipine has a pr...

journal_title：Current neurovascular research

authors： Aoki T,Kataoka H,Ishibashi R,Nozaki K,Hashimoto N

更新日期：2008-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...

journal_title：Current neurovascular research

authors： Kniewallner KM,Ehrlich D,Kiefer A,Marksteiner J,Humpel C

更新日期：2015-01-01 00:00:00

abstract：:In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...

journal_title：Current neurovascular research

authors： Giuseppe D,Sergio C,Pasqua B,Giovanni LV,Salvatore C,Frigiola A,Petra H,Maurizio A

更新日期：2009-05-01 00:00:00

abstract：:In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...

journal_title：Current neurovascular research

authors： Zamboni P,Menegatti E,Bartolomei I,Galeotti R,Malagoni AM,Tacconi G,Salvi F

更新日期：2007-11-01 00:00:00