Using endogenous neural stem cells to enhance recovery from ischemic brain injury.

abstract：:Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

journal_title：Current neurovascular research

authors： Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

更新日期：2009-08-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

journal_title：Current neurovascular research

authors： Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors fo...

journal_title：Current neurovascular research

authors： Xin J,Huang X,Pan X,Lin L,Sun M,Liu C,Ye Q

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...

journal_title：Current neurovascular research

authors： Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri F

更新日期：2020-12-01 00:00:00

abstract：:A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...

journal_title：Current neurovascular research

authors： Anne M,Juha K,Timo M,Mikko T,Olli V,Kyösti S,Heikki H,Vilho M

更新日期：2007-08-01 00:00:00

abstract：:Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the blood vessels starts with prominent hemorrhage and generation of inflammation. Fu...

journal_title：Current neurovascular research

authors： Graumann U,Ritz MF,Hausmann O

更新日期：2011-11-01 00:00:00

abstract：:No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...

journal_title：Current neurovascular research

authors： Chong ZZ,Li F,Maiese K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...

journal_title：Current neurovascular research

authors： Guo F,Kang J,Tan J,Wang Y,Jia L,Xu H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...

journal_title：Current neurovascular research

authors： Cheng WY,Chow KC,Chiao MT,Yang YC,Shen CC

更新日期：2020-01-01 00:00:00

abstract：:Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...

journal_title：Current neurovascular research

authors： Lin Y,Yu H,Song W,Zhang Y,Zhang C,Zhu Y,Pang Q,Hui R,Chen J

更新日期：2014-01-01 00:00:00

abstract：:This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...

journal_title：Current neurovascular research

authors： Pluta R

更新日期：2007-05-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...

journal_title：Current neurovascular research

authors： Chan RJ,Yoder MC

更新日期：2004-07-01 00:00:00

abstract：:This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...

journal_title：Current neurovascular research

authors： Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara H

更新日期：2015-01-01 00:00:00

abstract：:Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...

journal_title：Current neurovascular research

authors： Hutter-Schmid B,Humpel C

更新日期：2016-01-01 00:00:00

abstract：:In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angio...

journal_title：Current neurovascular research

authors： Sakamaki K

更新日期：2004-10-01 00:00:00

abstract：:The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

journal_title：Current neurovascular research

authors： Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

更新日期：2013-11-01 00:00:00

abstract：:Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...

journal_title：Current neurovascular research

authors： Chong ZZ,Lin SH,Li F,Maiese K

更新日期：2005-10-01 00:00:00

abstract：:Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...

journal_title：Current neurovascular research

authors： Ma XL,Liu KD,Li FC,Jiang XM,Jiang L,Li HL

更新日期：2013-05-01 00:00:00

abstract：:Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

journal_title：Current neurovascular research

authors： Wu W,Zhang S,Chen Y,Liu H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...

journal_title：Current neurovascular research

authors： Schulz VC,de Magalhaes PSC,Carneiro CC,da Silva JIT,Silva VN,Guesser VV,Safanelli J,Diegoli H,Liberato RB,Lopes CCC,de Souza A,de França PHC,Conforto AB,Cabral NL

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...

journal_title：Current neurovascular research

authors： Caprio MG,Marr K,Gandhi S,Jakimovski D,Hagemeier J,Weinstock-Guttman B,Zivadinov R,Mancini M

更新日期：2017-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...

journal_title：Current neurovascular research

authors： Hemmer B,Cepok S,Zhou D,Sommer N

更新日期：2004-04-01 00:00:00

abstract：:Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...

journal_title：Current neurovascular research

authors： Okouchi M,Okayama N,Alexander JS,Aw TY

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Whether preoperative midline shift and its growing rate are associated with outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction is unknown. METHODS:We retrospectively included patients: 1) who underwent decompressive craniectomy for malignant middle cerebral ar...

journal_title：Current neurovascular research

authors： Yuan R,Wu S,Cheng Y,Ye K,Hao Z,Zhang S,Liu Y,Liu M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

journal_title：Current neurovascular research

authors： Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...

journal_title：Current neurovascular research

authors： Wang H,Zhang Q,Xu Y,Bian H,Si C,Yan Z,Zhu M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

journal_title：Current neurovascular research

authors： Qu X,Shi J,Cao Y,Zhang M,Xu J

更新日期：2018-01-01 00:00:00

abstract：:Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...

journal_title：Current neurovascular research

authors： Menegatti E,Zamboni P

更新日期：2008-11-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...

journal_title：Current neurovascular research

authors： Liu X,Zhang J,Sun D,Fan Y,Zhou H,Fu B

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in t...

journal_title：Current neurovascular research

authors： Casas S,Perez AF,Mattiazzi M,Lopez J,Folgueira A,Gargiulo-Monachelli GM,Gonzalez Deniselle MC,De Nicola AF

更新日期：2017-01-01 00:00:00