Abstract:
:This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots were applied around the macular area using the image-guided laser system (532 nm) attached with Micron III at 650 mW-2,000 mW power. Laser pulse duration and spot size were fixed at 100 ms and 50 µm, respectively. At 14 days after laser irradiation, fluorescein angiograms were observed. At 21 days after laser irradiation, the fluorescein angiograms were transcardially perfused to the bilateral common carotid arteries with 4% paraformaldehyde for the transverse section or with fluorescein-conjugated dextran (MW = 2,000 kDa) for the retinal pigment epithelia (RPE)-choroidal flatmount. At 14 days after laser irradiation, late hyperfluorescence and leakage within or beyond the lesion borders were observed in a laser power-dependent manner. In the RPE-choroidal flatmount, the mean size of the CNV lesions at 1,500 mW was 1.34 ± 0.49 × 10(5) µm(2) (Mean ± S.D., n = 29), and the coefficient of variation for each CNV area was 36.5% (n = 29). In conclusion, we succeeded in producing an experimental exudative type of AMD model in the common marmoset. This model may be useful in elucidating the pathophysiological mechanism and screening of new candidates for exudative AMD.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara Hdoi
10.2174/1567202612666150311105814subject
Has Abstractpub_date
2015-01-01 00:00:00pages
128-34issue
2eissn
1567-2026issn
1875-5739pii
CNR-EPUB-65821journal_volume
12pub_type
杂志文章abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617999210101223129
更新日期:2021-01-01 00:00:00
abstract::In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angio...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362072
更新日期:2004-10-01 00:00:00
abstract::No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774962683
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666190129150403
更新日期:2019-01-01 00:00:00
abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160823164136
更新日期:2016-01-01 00:00:00
abstract::Cerebral aneurysm (CA) causes a life-threatening subarachnoid hemorrhage. However, no effective medical treatment to prevent the growth of CA is available. Nifedipine, a widely used calcium antagonist, was shown to improve endothelial function in various cardiovascular diseases. We examined whether nifedipine has a pr...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720208783565663
更新日期:2008-02-01 00:00:00
abstract::Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the blood vessels starts with prominent hemorrhage and generation of inflammation. Fu...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720211798121007
更新日期:2011-11-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362324
更新日期:2004-07-01 00:00:00
abstract::Increased homocysteine (Hcy) levels contribute to a variety of cardiovascular and cerebrovascular diseases including stroke and Alzheimer's disease. Recent data has shown that elevated levels of Hcy can lead to the blood-brain barrier (BBB) dysfunction and activation. However, the mechanism for Hcy-mediated dysfunctio...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720210792231787
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200521083132
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666201029145824
更新日期:2020-10-29 00:00:00
abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208786413442
更新日期:2008-11-01 00:00:00
abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207781387169
更新日期:2007-08-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150102124703
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666181204122457
更新日期:2018-01-01 00:00:00
abstract::Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202052773508
更新日期:2005-01-01 00:00:00
abstract::This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720207780637207
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180326101524
更新日期:2018-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043480152
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666170718095203
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200623123638
更新日期:2020-01-01 00:00:00
abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...
journal_title:Current neurovascular research
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720207779940699
更新日期:2007-02-01 00:00:00
abstract::In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207782446298
更新日期:2007-11-01 00:00:00
abstract::Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160219120411
更新日期:2016-01-01 00:00:00
abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720212801619018
更新日期:2012-08-01 00:00:00
abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160601144254
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180611120546
更新日期:2018-01-01 00:00:00
abstract::Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720211794520251
更新日期:2011-02-01 00:00:00
abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774322584
更新日期:2005-10-01 00:00:00
abstract::HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell struc...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208784310222
更新日期:2008-05-01 00:00:00