Deep brain stimulation for Stroke: Continuous stimulation of the pedunculopontine tegmental nucleus has no impact on skilled walking in rats after photothrombotic stroke.

Abstract:

BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuromodulation might be the pedunculopontine tegmental nucleus (PPTg), which contributes to the initiation and control of gait. To test this hypothesis, we trained eighteen rats to cross a horizontal ladder and a wooden beam before inflicting a photothrombosis in the right sensorimotor cortex and implanting a stimulating electrode in the ipsilateral PPTg. RESULTS:Continuous high-frequency DBS (130 Hz; amplitude 55 ± 5 µA) of rats for 10 days yielded no significant improvement of skilled walking when examined with the ladder rung walking test and beam walking test compared to shamstimulation. CONCLUSION:In contrast to DBS of the cuneiform nucleus, PPTg-stimulation improves neither control of gait nor balance after stroke.

journal_name

Curr Neurovasc Res

authors

Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri F

doi

10.2174/1567202617666201201141046

subject

Has Abstract

pub_date

2020-12-01 00:00:00

eissn

1567-2026

issn

1875-5739

pii

CNR-EPUB-111978

pub_type

杂志文章
  • NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis.

    abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720206778792876

    authors: Okouchi M,Okayama N,Alexander JS,Aw TY

    更新日期:2006-11-01 00:00:00

  • Platelets in the Alzheimer's disease brain: do they play a role in cerebral amyloid angiopathy?

    abstract::Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202612666150102124703

    authors: Kniewallner KM,Ehrlich D,Kiefer A,Marksteiner J,Humpel C

    更新日期:2015-01-01 00:00:00

  • The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways.

    abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720205774322584

    authors: Chong ZZ,Lin SH,Li F,Maiese K

    更新日期:2005-10-01 00:00:00

  • The multiple facets of hematopoietic stem cells.

    abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审

    doi:10.2174/1567202043362324

    authors: Chan RJ,Yoder MC

    更新日期:2004-07-01 00:00:00

  • Perinatal asphyxia in preterm neonates leads to serum changes in protein S-100 and neuron specific enolase.

    abstract::In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720209788185614

    authors: Giuseppe D,Sergio C,Pasqua B,Giovanni LV,Salvatore C,Frigiola A,Petra H,Maurizio A

    更新日期:2009-05-01 00:00:00

  • Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain.

    abstract::Brain edema following stroke is a critical clinical problem due to its association with increased morbidity and mortality. Despite its significance, present treatment for brain edema simply provides symptomatic relief due to the fact that molecular mechanisms underlying brain edema remain poorly understood. The presen...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720211794520251

    authors: Higashida T,Peng C,Li J,Dornbos D 3rd,Teng K,Li X,Kinni H,Guthikonda M,Ding Y

    更新日期:2011-02-01 00:00:00

  • Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study.

    abstract:BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202616666190129150403

    authors: Rosenbaum MD,Heiferman DM,Raslan OA,Martin B,Dominguez JF,de la Peña PM,Ashley WW,Rosenblum JD,Germanwala AV

    更新日期:2019-01-01 00:00:00

  • Identification of target antigens of antiendothelial cell antibodies against human brain microvascular endothelial cells in healthy subjects.

    abstract::Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In the present study, we evaluated AECAs against human brain microvascular endotheli...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202612666150107161847

    authors: Kimura A,Sakurai T,Yoshikura N,Koumura A,Hayashi Y,Ohtaki H,Chousa M,Seishima M,Inuzuka T

    更新日期:2015-01-01 00:00:00

  • Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity.

    abstract::No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720205774962683

    authors: Chong ZZ,Li F,Maiese K

    更新日期:2005-12-01 00:00:00

  • Using endogenous neural stem cells to enhance recovery from ischemic brain injury.

    abstract::The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation of embryonic stem cells ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审

    doi:10.2174/1567202043361938

    authors: Leker RR,McKay RD

    更新日期:2004-12-01 00:00:00

  • Prolactin and blood-brain barrier permeability.

    abstract::The blood-brain barrier (BBB) consists in part of a highly specialized set of cells which separates the brain from the vascular system. The BBB controls the entry and exit of substances from the brain tissue through tight junctions (TJs) between endothelial cells. It is known that the hormone prolactin (PRL) is able t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/15672026113109990025

    authors: Rosas-Hernandez H,Cuevas E,Lantz SM,Hamilton WR,Ramirez-Lee MA,Ali SF,Gonzalez C

    更新日期:2013-11-01 00:00:00

  • Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.

    abstract::This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720210793180765

    authors: Carvalho C,Santos MS,Baldeiras I,Oliveira CR,Seiça R,Moreira PI

    更新日期:2010-11-01 00:00:00

  • TRPA1 and TRPM8 Receptors May Promote Local Vasodilation that Aggravates Oxaliplatin-Induced Peripheral Neuropathy Amenable to 17β-Estradiol Treatment.

    abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202613666160601144254

    authors: Pan Y,Chen F,Huang S,Cai Z,Lan H,Tong Y,Yu X,Zhao G

    更新日期:2016-01-01 00:00:00

  • Improved Outcomes after Reperfusion Therapies for Ischemic Stroke: A "Real-world" Study in a Developing Country.

    abstract:BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202617666200521083132

    authors: Schulz VC,de Magalhaes PSC,Carneiro CC,da Silva JIT,Silva VN,Guesser VV,Safanelli J,Diegoli H,Liberato RB,Lopes CCC,de Souza A,de França PHC,Conforto AB,Cabral NL

    更新日期:2020-01-01 00:00:00

  • Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.

    abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202615666180326101524

    authors: Qu X,Shi J,Cao Y,Zhang M,Xu J

    更新日期:2018-01-01 00:00:00

  • Selective 5-HT7 Receptor Activation May Enhance Synaptic Plasticity Through N-methyl-D-aspartate (NMDA) Receptor Activity in the Visual Cortex.

    abstract::Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT receptors...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202613666160823164136

    authors: Xiang K,Zhao X,Li Y,Zheng L,Wang J,Li YH

    更新日期:2016-01-01 00:00:00

  • Doppler haemodynamics of cerebral venous return.

    abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...

    journal_title:Current neurovascular research

    pub_type: 杂志文章,评审

    doi:10.2174/156720208786413442

    authors: Menegatti E,Zamboni P

    更新日期:2008-11-01 00:00:00

  • Association of Non-Traditional Lipid Parameters with Hemorrhagic Transformation and Clinical Outcome After Thrombolysis in Ischemic Stroke Patients.

    abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202617999210101223129

    authors: Luo Y,Chen J,Yan XL,Jin H,Sun X,Guo ZN,Yang Y

    更新日期:2021-01-01 00:00:00

  • High Serum Alkaline Phosphatase Levels in Relation to Multi-Cerebral Microbleeds in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease.

    abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202613666160817095623

    authors: Liu J,Wang D,Li J,Xiong Y,Liu B,Wei C,Wu S,Liu M

    更新日期:2016-01-01 00:00:00

  • Biological Function and Mechanism of Bone Marrow Mesenchymal Stem Cells-packed Poly (3,4-ethylenedioxythiophene) (PEDOT) Scaffolds for Peripheral Nerve Injury: The Involvement of miR-21-Notch Signaling Pathway.

    abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202614666161123112832

    authors: Wu W,Zhang S,Chen Y,Liu H

    更新日期:2017-01-01 00:00:00

  • Human mesenchymal stem cells increases expression of α-tubulin and angiopoietin 1 and 2 in focal cerebral ischemia and reperfusion.

    abstract::Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202611310020003

    authors: Ma XL,Liu KD,Li FC,Jiang XM,Jiang L,Li HL

    更新日期:2013-05-01 00:00:00

  • Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202616666181204122457

    authors: Song Q,Li Y,Wang Y,Wei C,Liu J,Liu M

    更新日期:2018-01-01 00:00:00

  • An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset.

    abstract::This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202612666150311105814

    authors: Shimazawa M,Masuda T,Nakamura S,Miwa M,Nakamura K,Hara H

    更新日期:2015-01-01 00:00:00

  • Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke.

    abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720209788970036

    authors: Bossù P,Salani F,Cacciari C,Picchetto L,Cao M,Bizzoni F,Rasura M,Caltagirone C,Robinson RG,Orzi F,Spalletta G

    更新日期:2009-08-01 00:00:00

  • Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke.

    abstract:BACKGROUND:Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in t...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202614666171005122925

    authors: Casas S,Perez AF,Mattiazzi M,Lopez J,Folgueira A,Gargiulo-Monachelli GM,Gonzalez Deniselle MC,De Nicola AF

    更新日期:2017-01-01 00:00:00

  • Risk Factors for Aphasia in Cerebral Small Vessel Diseases.

    abstract:BACKGROUND:Lacunes and white matter hyperintensities (WMH) are two common findings seen on neuroimaging in patients with cerebral small vessel disease (cSVD). Clinically we observed that some patients with cSVD have aphasia through the language assessment scale. Our study aimed to explore the underlying risk factors fo...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202616666190227202638

    authors: Xin J,Huang X,Pan X,Lin L,Sun M,Liu C,Ye Q

    更新日期:2019-01-01 00:00:00

  • Elevated Serum Homocysteine Associated with Distal Type of Single Small Subcortical Infarction.

    abstract:OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202617666201029145824

    authors: Liu C,Gao Y,Song B,Wang Y,Pei L,Li S,Xu Y,Li Y

    更新日期:2020-10-29 00:00:00

  • Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia.

    abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/156720212801619018

    authors: Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RR

    更新日期:2012-08-01 00:00:00

  • Platelet-derived Growth Factor Receptor-beta is Differentially Regulated in Primary Mouse Pericytes and Brain Slices.

    abstract::Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202613666160219120411

    authors: Hutter-Schmid B,Humpel C

    更新日期:2016-01-01 00:00:00

  • Early timing of endovascular treatment for aneurysmal subarachnoid hemorrhage achieves improved outcomes.

    abstract::Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...

    journal_title:Current neurovascular research

    pub_type: 杂志文章

    doi:10.2174/1567202610666131210104606

    authors: Qian Z,Peng T,Liu A,Li Y,Jiang C,Yang H,Wu J,Kang H,Wu Z

    更新日期:2014-02-01 00:00:00