Abstract:
BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuromodulation might be the pedunculopontine tegmental nucleus (PPTg), which contributes to the initiation and control of gait. To test this hypothesis, we trained eighteen rats to cross a horizontal ladder and a wooden beam before inflicting a photothrombosis in the right sensorimotor cortex and implanting a stimulating electrode in the ipsilateral PPTg. RESULTS:Continuous high-frequency DBS (130 Hz; amplitude 55 ± 5 µA) of rats for 10 days yielded no significant improvement of skilled walking when examined with the ladder rung walking test and beam walking test compared to shamstimulation. CONCLUSION:In contrast to DBS of the cuneiform nucleus, PPTg-stimulation improves neither control of gait nor balance after stroke.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Bohr A,Schuhmann MK,Papp L,Volkmann J,Fluri Fdoi
10.2174/1567202617666201201141046subject
Has Abstractpub_date
2020-12-01 00:00:00eissn
1567-2026issn
1875-5739pii
CNR-EPUB-111978pub_type
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