Abstract:
:Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine the effects of PMP therapy in-vivo, we delivered PMP or vehicle via a biodegradable polymer to the brain surface after permanent middle cerebral artery occlusion (PMCAO) in rats. Rats were tested with the neurological severity score and infarct volumes were measured at 90 days post-ischemia. Immunohistochemistry was used to determine the fate of newborn cells and to count blood vessels in the ischemic brain. The results show that PMP led to a dose dependent increase in cell proliferation, neurogenesis and angiogenesis at the infarct boundary zone and significantly improved behavioral deficits.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Hayon Y,Dashevsky O,Shai E,Brill A,Varon D,Leker RRdoi
10.2174/156720212801619018subject
Has Abstractpub_date
2012-08-01 00:00:00pages
185-92issue
3eissn
1567-2026issn
1875-5739pii
CNR-EPUB-20120523-4journal_volume
9pub_type
杂志文章abstract::Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker. The aim of...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160219120411
更新日期:2016-01-01 00:00:00
abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...
journal_title:Current neurovascular research
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720207779940699
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180326101524
更新日期:2018-01-01 00:00:00
abstract::This review demonstrated that ischemic brain injury induces chronic changes in blood-brain barrier in the gray and white matter. This insufficiency of blood-brain barrier may allow entry of uncellular blood components such as different fragments of amyloid precursor protein and cellular blood components like leukocyte...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720207780637207
更新日期:2007-05-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043480152
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617999210101223129
更新日期:2021-01-01 00:00:00
abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208786413442
更新日期:2008-11-01 00:00:00
abstract::Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence of antigens or micro...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202053586776
更新日期:2005-04-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362324
更新日期:2004-07-01 00:00:00
abstract::Intracranial aneurysms (IAs) are acquired lesions in the brain and can pose potential risk of rupture leading to subarachnoid hemorrhage. Endoglin plays a pivotal role in the vascular development and disease. Variations of endoglin gene have been shown to be risk factors for IAs in different racial population. In the ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202611666140912114450
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666170718095203
更新日期:2017-01-01 00:00:00
abstract::N-methyl-D-aspartate receptors (NMDA-Rs) activation has been implicated in various forms of synaptic plasticity depending on the receptor subtypes involved. However, the contribution of NR2A and NR2B subunits in glycine-induced long-term potentiation (LTP) of miniature excitatory postsynaptic currents (mEPSCs) in laye...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720213804805927
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes are supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuropr...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666170619081419
更新日期:2017-01-01 00:00:00
abstract::This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150311105814
更新日期:2015-01-01 00:00:00
abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160817095623
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200217105109
更新日期:2020-01-01 00:00:00
abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207781387169
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180611120546
更新日期:2018-01-01 00:00:00
abstract::In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207782446298
更新日期:2007-11-01 00:00:00
abstract::This study was aimed to evaluate and compare the effect of chronic hypoxia and aging in the oxidative status of brain vessels and synaptosomes. For this purpose we isolated brain vessels and synaptosomes from 3- and 12-month-old rats subjected to chronic hypoxia (10% O₂ for 7 days) or normoxia (21% O₂). Several parame...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720210793180765
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Acute Ischemic Stroke (AIS) represents an economic challenge for health systems all over the globe. Changes of neuroactive steroids have been found in different neurological diseases. We have previously demonstrated that old patients with AIS show changes of plasma cortisol and estradiol concentrations, in t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666171005122925
更新日期:2017-01-01 00:00:00
abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720206778792876
更新日期:2006-11-01 00:00:00
abstract::In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788185614
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma multiforme (GBM). METHODS:DRP1 expre...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200623123638
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocyte is currently known as a potential risk factor for symptomatic intracranial hemorrhage after reperfusion therapy, but there is little evidence on whether leukocyte is associated with the overall risk of Hemorrhagic Transformation (HT) after Acute Ischemic Stroke (AIS). METHODS:Patients ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666181204122457
更新日期:2018-01-01 00:00:00
abstract::Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:
更新日期:2013-08-19 00:00:00
abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788970036
更新日期:2009-08-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall resp...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150102124703
更新日期:2015-01-01 00:00:00
abstract::HspB5/alphaB-crystallin (alphaBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell struc...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208784310222
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200521083132
更新日期:2020-01-01 00:00:00