Abstract:
:Alzheimer's disease is a progressive disorder that results in the loss of cognitive function and memory. Although traditionally defined by the presence of extracellular plaques of amyloid-beta peptide aggregates and intracellular neurofibrillary tangles in the brain, more recent work has begun to focus on elucidating the complexities of Alzheimer's disease that involve the generation of reactive oxygen species and oxidative stress. Apoptotic processes that are incurred as a function of oxidative stress affect neuronal, vascular, and monocyte derived cell populations. In particular, it is the early apoptotic induction of cellular membrane asymmetry loss that drives inflammatory microglial activation and subsequent neuronal and vascular injury. In this article, we discuss the role of novel cellular pathways that are invoked during oxidative stress and may potentially mediate apoptotic injury in Alzheimer's disease. Ultimately, targeting new avenues for the development of therapeutic strategies linked to mechanisms that involve inflammatory microglial activation, cellular metabolism, cell-cycle regulation, G-protein regulated receptors, and cytokine modulation may provide fruitful gains for both the prevention and treatment of Alzheimer's disease.
journal_name
Curr Neurovasc Resjournal_title
Current neurovascular researchauthors
Chong ZZ,Li F,Maiese Kdoi
10.2174/1567202052773508keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
55-72issue
1eissn
1567-2026issn
1875-5739journal_volume
2pub_type
杂志文章,评审abstract::Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detected in healthy subjects. In the present study, we evaluated AECAs against human brain microvascular endotheli...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150107161847
更新日期:2015-01-01 00:00:00
abstract::In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information on the intracranial venous haemodynamics of MS is availa...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207782446298
更新日期:2007-11-01 00:00:00
abstract::This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n=24) control...
journal_title:Current neurovascular research
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720207779940699
更新日期:2007-02-01 00:00:00
abstract::Hematopoietic stem cells (HSCs) have long been defined as a cell with the capacity to repopulate the hematopoietic system of a lethally irradiated host. In clinical medicine, this property has been employed to reconstitute an individual's diseased hematopoietic system following ablation with a healthy, normal-function...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043362324
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Endothelial Progenitor Cells (EPCs) have been suggested to be a therapeutic option in Acute Ischemic Stroke (AIS). Statins modulate endothelial function and preserve blood flow to tissue exposed to an ischemic insult. We tested the hypothesis that statins therapy might augment circulating EPCs in patients wi...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202615666180611120546
更新日期:2018-01-01 00:00:00
abstract::Understanding the role of nicotinamide (NIC) in different cell systems represents a significant challenge in several respects. Recently, NIC has been reported to have diverse roles during cell biology. In the absence of NIC, sirtuin protein activity is enhanced and pyrazinamidase/nicotinamidase 1 (PNC1) expression, an...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774322584
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Intracranial aneurysms (IAs) are life-threatening lesions known within the literature to be found incidentally during routine angiographic workup for carotid artery stenosis (CAS). As IAs are associated with vascular shear stress, it is reasonable to expect that altered flow demands within the anterior circu...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202616666190129150403
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:It is unknown if improvements in ischemic stroke (IS) outcomes reported after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the "real world" scenario of low and middle-income countries. We aimed to measure the long-term outcomes of severe IS treated or not with CRT in Bra...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200521083132
更新日期:2020-01-01 00:00:00
abstract::Physiologic functioning of the cerebrovenous system is indispensable for maintaining normal brain function. However, in contrast to the cerebroarterial system, the cerebral venous return is not routinely investigated. Combined high-resolution echo-colour-Doppler (ECD) and transcranial colour coded Doppler sonography (...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/156720208786413442
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Recently, a few studies have shown that non-traditional lipid parameters are associated with the hemorrhagic transformation (HT) and the clinical outcome of ischemic stroke. However, the role of non-traditional lipid parameters in ischemic stroke patients treated with intravenous thrombolysis remains unclear....
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617999210101223129
更新日期:2021-01-01 00:00:00
abstract::In preterm infants, neurological signs and clinical manifestations of brain damage are limited criteria for diagnosis of neurologic sequelae. Early indicators of brain damage are needed and currently some specific biochemical markers of brain injury are investigated to assess regional brain damage after perinatal asph...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788185614
更新日期:2009-05-01 00:00:00
abstract::A stress response consisting of elevated levels of cortisol and catecholamines is common after acute stroke. The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the acute phase of stroke and their impact on long-term prognosis ha...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720207781387169
更新日期:2007-08-01 00:00:00
abstract::This study aimed to establish an experimental exudative age-related macular degeneration (AMD) model in the common marmoset (Callithrix jacchus), which is a small New World monkey. Choroidal neovascularization (CNV) was induced by laser irradiation on the left eye of each animal under anesthesia. Eight laser spots wer...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666150311105814
更新日期:2015-01-01 00:00:00
abstract::Angiogenesis is associated with improved neurologic recovery after cerebral ischemia. Human bone marrow mesenchymal stem cells (hMSCs) have been successfully used to treat ischemic stroke and were shown to induce the expression of a number of neurotrophic factors including VEGF, epidermal growth factor (EGF) and basic...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202611310020003
更新日期:2013-05-01 00:00:00
abstract::Ununited peripheral nerves represent attractive site for connectivity with neuroprostheses because their predictable internal topography allows precise sorting of motor and sensory signals. Also transplantation of bone marrow mesenchymal stem cells (BMSCs) is increasingly recognized as an effective method of restore t...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202614666161123112832
更新日期:2017-01-01 00:00:00
abstract::Diabetes is associated with deficits in memory and cognitive functions and sustained inflammation. Recently, involvement of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) has been postulated in many cognitive functions, immune system and inflammation. Despite of role of NF-κB in inflammation, a...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202612666151030104810
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). METHODS:Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and r...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666201029145824
更新日期:2020-10-29 00:00:00
abstract:BACKGROUND:Iron homeostasis disorder and neuroinflammation are the most commonly known factors that promote the occurrence and development of cognitive impairment in people. Dexmedetomidine has an anti-inflammatory effect, and it reduces the incidence of postoperative cognitive dysfunction. Therefore, the aim of this s...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666200217105109
更新日期:2020-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043480152
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Gait impairment after stroke is considered as a loss of cerebral function but is also the result of dysfunctional cerebral signals travelling to the spinal motor centres. A therapeutic option to restore disturbed cerebral network activity is deep brain stimulation (DBS). METHODS:A promising target for neuro...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202617666201201141046
更新日期:2020-12-01 00:00:00
abstract::Stroke has been shown to lead to depressive disorders, anxiety disorders and other emotional consequences. Although the cause of these disorders is a subject of debate, stroke has clearly been shown to lead to the production of pro-inflammatory cytokines, which we hypothesized to play a role in the production of post-...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720209788970036
更新日期:2009-08-01 00:00:00
abstract::Timing of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hem...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202610666131210104606
更新日期:2014-02-01 00:00:00
abstract::Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an op...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:
更新日期:2013-08-19 00:00:00
abstract::Elevated alkaline phosphatase (ALP) levels are associated with cerebral small vascular diseases, such as silent brain infarction and cerebral white matter hyperintensity (cWMH), but few prospective data are available for cerebral microbleeds (CMBs). The aim of the study was to investigate associations between serum AL...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160817095623
更新日期:2016-01-01 00:00:00
abstract::Activated platelets shed microparticles, which contain a variety of growth factors central to angiogenesis and neurogenesis. The aim of this study was to explore whether platelet derived microparticles (PMP) can boost endogenous neural stem cells dependent repair mechanisms following stroke in a rat model. To examine ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720212801619018
更新日期:2012-08-01 00:00:00
abstract::Oxaliplatin is a widely used chemotherapeutic agent that induces both acute and chronic peripheral neuropathy. Based on previous research indicating that estrogen replacement may attenuate some forms of pain in ovariectomized animals, we examined the effects of 17β-estradiol in OXAIPN. We discovered that local cold ex...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/1567202613666160601144254
更新日期:2016-01-01 00:00:00
abstract::The use of cell-based therapy may be a valid therapeutic approach to ischemic brain injury. Stem cells have been proposed as a new form of cell based therapy in a variety of disorders, including acute and degenerative brain diseases. Up to date most efforts have concentrated on transplantation of embryonic stem cells ...
journal_title:Current neurovascular research
pub_type: 杂志文章,评审
doi:10.2174/1567202043361938
更新日期:2004-12-01 00:00:00
abstract::Increased oxidative stress and susceptibility of brain endothelium are contributing factors in the development of central nervous system complications in neuro-degenerative disorders in diabetes, Alzheimer's and Parkinson's disease. The molecular mechanisms underpinning the vulnerability of brain endothelial cells to ...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720206778792876
更新日期:2006-11-01 00:00:00
abstract::Cerebral aneurysm (CA) causes a life-threatening subarachnoid hemorrhage. However, no effective medical treatment to prevent the growth of CA is available. Nifedipine, a widely used calcium antagonist, was shown to improve endothelial function in various cardiovascular diseases. We examined whether nifedipine has a pr...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720208783565663
更新日期:2008-02-01 00:00:00
abstract::No longer considered exclusive for the function of the hematopoietic system, erythropoietin (EPO) is now considered as a viable agent to address central nervous system injury in a variety of cellular systems that involve neuronal, vascular, and inflammatory cells. Yet, it remains unclear whether the protective capacit...
journal_title:Current neurovascular research
pub_type: 杂志文章
doi:10.2174/156720205774962683
更新日期:2005-12-01 00:00:00