Plastic embedded core biopsy: a complementary approach to bone marrow aspiration for diagnosing acute myeloid leukaemia.

Abstract:

:Bone marrow aspirates and biopsy specimens were taken at diagnosis from 51 patients with acute myeloid leukaemia (AML). The diagnosis was based on morphological and cytochemical analyses, and the leukaemias were classified by FAB criteria. A considerable difference was observed between the results of bone marrow aspirates and the findings of plastic-embedded bone marrow biopsy specimens, particularly in marrow cellularity, extent of blast cell infiltration, and cell type involved in the leukaemic process. The myelomonocytic cell type seemed to predominate in the sections. In four cases there was considerable marrow infiltration with maturing, but dysplastic, granulocytic cells in the sections, but not in the aspirate smears. Features of potential prognostic importance, such as bone marrow infiltration with inflammatory cells, were easily recognised and quantified in the sections. These results indicate that plastic embedded bone marrow biopsy sections complement the findings of bone marrow aspiration in the diagnosis of AML and may also provide information of independent prognostic importance that cannot be obtained by other means.

journal_name

J Clin Pathol

authors

Islam A,Frisch B,Henderson ES

doi

10.1136/jcp.42.3.300

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

300-6

issue

3

eissn

0021-9746

issn

1472-4146

journal_volume

42

pub_type

杂志文章
  • Neutron activation analysis ofr copper in biological material applied to Wilson's disease.

    abstract::A method for the neutron activation analysis of copper in biological material is described and applied to the diagnosis and management of four cases of Wilson's disease. Results obtained for serum and urine are in agreement with values obtained by established colorimetric techniques. The method described can estimate ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.21.1.8

    authors: Fell GS,Smith H,Howie RA

    更新日期:1968-01-01 00:00:00

  • Chronic alcoholic skeletal muscle myopathy: a clinical, histological and biochemical assessment of muscle lipid.

    abstract::Muscle biopsy samples were analysed from five control subjects, four patients with mild to moderate fibre atrophy and four patients with severe atrophy. Patchy increase in lipid was noted with oil red O staining but there was no consistent association of lipid with selective fibre types. Ultrastructural studies demons...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.7.778

    authors: Sunnasy D,Cairns SR,Martin F,Slavin G,Peters TJ

    更新日期:1983-07-01 00:00:00

  • Squamous differentiation in carcinoma in situ of the cervix uteri. A cyto-histological correlation of malignant intraepithelial lesions with invasive carcinoma.

    abstract::Cervical biopsies from 97 women with malignant cells in cervical scrape smears have been studied. Forty-eight patients had invasive squamous carcinoma, and 49 had intraepithelial lesions. Of these, six had dedifferentiated carcinoma in situ, nine had the differentiated lesions generally known as ;severe dysplasia', an...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.20.1.7

    authors: Grubb C,Janota I

    更新日期:1967-01-01 00:00:00

  • Screening of blood donors for the detection of antitetanus antibodies suitable for the production of human antitetanus immunoglobulin.

    abstract::During a 12-month period, 40 146 blood donors were tested for the presence of high titre antitetanus antibodies. An attempt has been made to define the most suitable donors, those with antitetanus antibody titres of 4 IU/ml or above, by virtue of titre, sex, location, and length of time since most recent immunisation...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.30.2.177

    authors: Wiseman IC,Gascoigne ME

    更新日期:1977-02-01 00:00:00

  • Aneuploidy and malignancy: an unsolved equation.

    abstract::Aneuploidy is frequently noted in malignant tumours. There is much controversy about its cause and effect in relation to malignant tumours. Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. Telomere dysfunction may also ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2004.018952

    authors: Dey P

    更新日期:2004-12-01 00:00:00

  • Distribution of fibronectin and laminin in normal and pathological lymphoid tissue.

    abstract::Forty six lymph nodes were examined with the indirect immunoperoxidase technique for the distribution of fibronectin and laminin. Fibronectin was present in the framework of the tissue and the basal lamina of blood vessels, giving a clear outline of nodal architecture. Intracellular fibronectin was observed in cases o...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.38.8.849

    authors: Reilly JT,Nash JR,Mackie MJ,McVerry BA

    更新日期:1985-08-01 00:00:00

  • Visual versus mechanised leucocyte differential counts: costing and evaluation of traditional and Hemalog D methods.

    abstract::Visual differential counts were examined for efficiency, cost effectiveness, and staff acceptability within our laboratory. A comparison with the Hemalog D system was attempted. The advantages and disadvantages of each system are enumerated and discussed in the context of a large general hospital. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.33.11.1114

    authors: Hudson MJ,Green AE

    更新日期:1980-11-01 00:00:00

  • CLINICAL VALUE OF THE CORTISOL SECRETION RATE.

    abstract::The isotopic estimation of the cortisol secretion rate in man is now an accepted and reliable method of assaying adrenal cortical function.Seven years' experience with its clinical use is reviewed and some practical aspects of technique are considered. The mean normal resting cortisol secretion rate is 16.2 +/- 5.7 mg...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.18.1.82

    authors: COPE CL,PEARSON J

    更新日期:1965-01-01 00:00:00

  • Diagnosis of human toxocariasis by antigen capture enzyme linked immunosorbent assay.

    abstract:AIMS:To evaluate an antigen capture enzyme linked immunosorbent assay (ELISA) which detects a carbohydrate epitope on the excretory-secretory (ES) antigens of Toxocara canis in clinical practice. METHODS:Serum specimens from healthy adults, patients with acute visceral larva migrans, ocular and inactive toxocariasis, ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.46.6.551

    authors: Gillespie SH,Bidwell D,Voller A,Robertson BD,Maizels RM

    更新日期:1993-06-01 00:00:00

  • A rapid immunoperoxidase assay for the detection of specific IgG antibodies to Chlamydia trachomatis.

    abstract::A technique, using indirect immunoperoxidase antibody (IPA), was developed for the detection of IgG antibody to Chlamydia trachomatis. The IPA technique employs glass slides with air-dried and acetone-fixed C trachomatis infected cells, which can be stored at -70 degrees C and used for several months. Antibody titres ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.3.353

    authors: Cevenini R,Rumpianesi F,Donati M,Sarov I

    更新日期:1983-03-01 00:00:00

  • Immunohistochemical localisation of tissue plasminogen activator and urokinase in the vessel wall.

    abstract::Immunoreactive plasminogen activators were studied in tissue sections using a peroxidase method and monospecific antibodies to tissue plasminogen activator produced by a melanoma. Tissue plasminogen activator reactivity was found in skin melanomas and in endothelial and smooth muscle cells of arteries and veins. Vesse...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.38.2.140

    authors: Larsson A,Astedt B

    更新日期:1985-02-01 00:00:00

  • Development of a radioimmunoassay for measuring gonadotrophin releasing hormone in patients receiving treatment.

    abstract::A radioimmunoassay for the measurement of gonadotrophin releasing hormone (GnRH) in plasma and urine using readily available reagents was developed. The GnRH assay showed good precision, recovery, and parallelism over a wide range of GnRH concentrations with a sensitivity of 15 pg/ml. The assay was compared with a com...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.5.542

    authors: Mosby VA,Knapp ML,Fink RS,Osgood VM,Mayne PD

    更新日期:1989-05-01 00:00:00

  • Spherical connective tissue inclusions in epithelial hyperplasia of the breast ("collagenous spherulosis").

    abstract::Partial myoepithelial differentiation is common in simple epithelial hyperplasia (epitheliosis) of the breast but functional myoepithelial differentiation with basement membrane production is exceedingly rare. A peculiar change of hyaline globules within benign epithelial hyperplasia has been recognised before as "col...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.43.11.905

    authors: Wells CA,Wells CW,Yeomans P,Viña M,Jordan S,d'Ardenne AJ

    更新日期:1990-11-01 00:00:00

  • Rubella virus serology:detection of residual lipoprotein inhibitors of haemagglutination using sensitive indicator arboviruses.

    abstract::Immune and non-immune rubella sera were examined in the haemagglutination inhibition (HAI) test to evaluate the removal of lipoprotein non-specific inhibitors (NSI) of haemagglutination after kaolin and manganous chloride/heparin treatments. The sera were titrated fresh or after lipoprotein deterioration brought about...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.30.5.409

    authors: Shortridge KF

    更新日期:1977-05-01 00:00:00

  • Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant.

    abstract::A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.55.10.784

    authors: Gompels MM,Bethune CA,Jackson G,Spickett GP

    更新日期:2002-10-01 00:00:00

  • Adenocarcinoma of the anal glands.

    abstract::Adenocarcinoma of the anal glands is very rare but it is an important lesion to recognise as with early diagnosis, it has an excellent prognosis. Because it involves the submucosa widely and penetrates the mucosa late, it can be mistaken for metastatic gastrointestinal carcinoma, or tumour arising in sinuses and fistu...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.49.12.1009

    authors: Behan WM,Burnett RA

    更新日期:1996-12-01 00:00:00

  • Urinary excretion kinetics of hydroxyethyl starch 350/0.60 in normovolaemic man.

    abstract::Rates of urinary excretion concomitant with the molecular size distribution of filtered polymer fragments were determined in five normovolaemic men dosed with 30 g/m2 BSA of a species of HES (HES 350/0.60) possessing a M-W of 350 000 combined with an MS of 0.60. Approximately 13% of the total injected dose of HES 350/...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.4.361

    authors: Mishler JM,Ricketts CR,Parkhouse EJ

    更新日期:1981-04-01 00:00:00

  • Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.

    abstract::Using a radioimmunoassay technique serum alpha-fetoprotein could be detected in healthy adults in concentrations of less than 20 microgram/l. Of patients with acute, viral hepatitis 43% exhibited a transient rise of serum alpha-fetoprotein, the peak occurring eight to nine days after the maximum recorded serum asparta...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.30.8.704

    authors: Eleftheriou N,Heathcote J,Thomas HC,Sherlock S

    更新日期:1977-08-01 00:00:00

  • Foveolar hyperplasia at the gastric cardia: prevalence and associations.

    abstract:AIMS:In the gastric antrum and body, foveolar hyperplasia is a feature of reactive gastritis resulting from--for example, duodenogastric bile reflux and the use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of this study was to examine the occurrence and clinical relevance of gastric cardiac foveolar hyper...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.55.5.352

    authors: Voutilainen M,Juhola M,Färkkilä M,Sipponen P

    更新日期:2002-05-01 00:00:00

  • Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis.

    abstract:AIM:Primary biliary cirrhosis (PBC) is characterised by antimitochondrial antibody against the pyruvate dehydrogenase complex (PDC) and chronic non-suppurative destructive cholangitis (CNSDC). Pyruvate oxidation to acetyl-CoA by PDC is a key step in the glycolytic system. Oestrogen-related receptor-α (ERRα) is function...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2013-201815

    authors: Harada K,Kakuda Y,Sato Y,Ikeda H,Shimoda S,Yamamoto Y,Inoue H,Ohta H,Kasashima S,Kawashima A,Nakanuma Y

    更新日期:2014-05-01 00:00:00

  • Pseudoangiomatous hyperplasia of mammary stroma associated with gynaecomastia.

    abstract:AIMS:To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS:Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In th...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.51.3.204

    authors: Milanezi MF,Saggioro FP,Zanati SG,Bazan R,Schmitt FC

    更新日期:1998-03-01 00:00:00

  • Audit of laboratory mycology services for the management of patients with fungal infections in the northwest of England.

    abstract:BACKGROUND:Fungal infection is increasingly recognised as an important cause of morbidity and mortality, especially in immunocompromised patients. Little information exists on laboratory services available and the methods used by general microbiology laboratories to diagnose these important infections. AIM:To investig...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1136/jcp.2005.034108

    authors: Hassan IA,Critten P,Isalska B,Denning DW

    更新日期:2006-07-01 00:00:00

  • Immunohistological characterisation of amyloid deposits in renal biopsy specimens.

    abstract::The amyloid deposits in 21 renal biopsy specimens were subjected to a detailed immunohistochemical analysis using a panel of antibodies against recognised constituents of tissue amyloid. This was a retrospective study of material originally submitted during the investigation of various renal abnormalities and studied ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.44.3.200

    authors: Fitzmaurice RJ,Bartley C,McClure J,Ackrill P

    更新日期:1991-03-01 00:00:00

  • Rapid cytological diagnosis of basal cell carcinoma of the skin.

    abstract::Cytological diagnosis in a series of 153 skin lesions is presented. The diagnosis in each case has been compared with the clinical assessment and, where available, the biopsy result (85 lesions). Of 131 basal cell carcinomas, a cytological diagnosis was possible in 124 while biopsyl failed to identify two of the 73 le...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.4.361

    authors: Brown CL,Klaber MR,Robertson MG

    更新日期:1979-04-01 00:00:00

  • The weights of kidneys in late intrautrine life and childhood.

    abstract::Statistical tables including 50 and 95 percentile ranges are presented of the combined kidney weights compared with body weight, crown-rump length, and gestation age of foetuses and newborn children, and also a table of kidney weights related to post-natal age. The importance of relating kidney weight to more than one...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.13.6.490

    authors: EMERY JL,MITHAL A

    更新日期:1960-11-01 00:00:00

  • Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence.

    abstract::This report describes a patient with a gastric biopsy specimen showing histomorphological and immunohistochemical appearances indistinguishable from those usually present in lymphocytic gastritis, a rare condition of unknown aetiology with a distinctive phenotype. The patient had a history of a biopsy confirmed T cell...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2004.017350

    authors: Nga ME,Tan SH,Teh M,Koay ES,Chong SM,Putti TC,Salto-Tellez M

    更新日期:2004-11-01 00:00:00

  • Vibrio vulnificus: an unusual mode of acquisition and novel use of rapid susceptibility testing.

    abstract::Infection with Vibrio vulnificus is uncommon in Europe but is associated with necrotising wound infections and life-threatening septicaemia. This case is one of infection most likely to have been acquired from a thermal pool in Turkey without preceding exposure to seawater or shellfish. The report also describes how e...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2008.059238

    authors: Partridge DG,Townsend R,Larkin S,Parsons HK

    更新日期:2009-04-01 00:00:00

  • The HLA system: immunobiology, HLA typing, antibody screening and crossmatching techniques.

    abstract::The Human Leukocyte Antigen (HLA) system plays a critical role in regulating the immune response. As a consequence of its role in immune regulation and exquisite polymorphism, the HLA system also constitutes an immunological barrier which must be avoided or otherwise overcome in clinical transplantation. This introduc...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2009.072371

    authors: Howell WM,Carter V,Clark B

    更新日期:2010-05-01 00:00:00

  • The assay and properties of labile factor (factor V).

    abstract::Human oxalated plasma stored at 4 degrees C. until the prothrombin time is increased beyond 60 sec. is a reliable medium for assaying labile factor (factor V) because its response to added labile factor corresponds quantitatively to that of plasma from patients with congenital deficiency of this factor. Such an agreem...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.13.6.457

    authors: QUICK AJ

    更新日期:1960-11-01 00:00:00

  • Immunohistochemical assays in prostatic biopsies processed in Bouin's fixative.

    abstract:AIMS:To investigate the problems involved in undertaking immunohistochemistry (IHC) and nuclear morphometry using Bouin's fixed prostate biopsies. METHODS:Archival Bouin's fixed and formalin fixed, paraffin wax embedded prostatic biopsies were immunostained for three nuclear biomarkers (minichromosome maintenance prot...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2004.019299

    authors: Ananthanarayanan V,Pins MR,Meyer RE,Gann PH

    更新日期:2005-03-01 00:00:00