Plastic embedded core biopsy: a complementary approach to bone marrow aspiration for diagnosing acute myeloid leukaemia.


:Bone marrow aspirates and biopsy specimens were taken at diagnosis from 51 patients with acute myeloid leukaemia (AML). The diagnosis was based on morphological and cytochemical analyses, and the leukaemias were classified by FAB criteria. A considerable difference was observed between the results of bone marrow aspirates and the findings of plastic-embedded bone marrow biopsy specimens, particularly in marrow cellularity, extent of blast cell infiltration, and cell type involved in the leukaemic process. The myelomonocytic cell type seemed to predominate in the sections. In four cases there was considerable marrow infiltration with maturing, but dysplastic, granulocytic cells in the sections, but not in the aspirate smears. Features of potential prognostic importance, such as bone marrow infiltration with inflammatory cells, were easily recognised and quantified in the sections. These results indicate that plastic embedded bone marrow biopsy sections complement the findings of bone marrow aspiration in the diagnosis of AML and may also provide information of independent prognostic importance that cannot be obtained by other means.


J Clin Pathol


Islam A,Frisch B,Henderson ES




Has Abstract


1989-03-01 00:00:00












  • A study in vitro of the sensitivity to antibiotics of Bacteroides fragilis.

    abstract::During a two-year period of observation Bacteroides species were isolated from specimens of pus and vaginal swabs from 115 patients in this hospital. Thirty-five representative strains proved on examination to be Bacteroides fragilis. Minimal inhibitory and minimal bactericidal concentrations of six antibiotics for th...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Ingham HR,Selkon JB,Codd AA,Hale JH

    更新日期:1968-07-01 00:00:00

  • Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma.

    abstract:AIMS:To study the homozygous deletion and methylation status of the 5' CpG island of the p16 and p15 genes (9p21) in a set of primary advanced head and neck squamous cell carcinomas (SCC) and to test whether inactivation of these genes by these mechanisms contributes to head and neck SCC development. METHODS:DNA was e...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: González MV,Pello MF,López-Larrea C,Suárez C,Menéndez MJ,Coto E

    更新日期:1997-06-01 00:00:00

  • Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities in north London blood donors.

    abstract::Serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GT) activities were measured in over 2000 north London blood donors. The results were compared with those from the United States. The percentage of the total donor population with ALT activities above 40 IU/l in 1986 was greater than that found ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Mijovic V,Contreras M,Barbara J

    更新日期:1987-11-01 00:00:00

  • Serial plasmapheresis in a haemophiliac with antibodies to FVIII.

    abstract::Serial plasmaphereses were performed on a 23-year-old haemophiliac, with antibodies to factor VIII (FVIII), in order to reduce the antibody level before multiple dental extractions. Eight phereses were carried out in which approximately 1.5 litres plasma was exchanged with isotonic saline. By the ninth exchange, which...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Cobcroft R,Tamagnini G,Dormandy KM

    更新日期:1977-08-01 00:00:00

  • Mixed lymphocyte reactions do not predict severity of graft versus host disease (GVHD) in HLA-DR compatible, sibling bone marrow transplants.

    abstract::Mixed lymphocyte reactions (MLRs) were measured in 25 HLA-A, B and DR compatible sibling bone marrow transplants. Only four of 25 MLRs were positive and in these the low reactivity was of doubtful clinical importance. There was no correlation between MLR and the subsequent development or severity of graft versus host ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Lim SH,Patton WN,Jobson S,Gentle TA,Baynham M,Franklin IM,Broughton BJ

    更新日期:1988-11-01 00:00:00

  • Risk of recurrence estimates with IHC4+C are tolerant of variations in staining and scoring: an analytical validity study.

    abstract:AIMS:The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,多中心研究


    authors: Dodson A,Zabaglo L,Yeo B,Miller K,Smith I,Dowsett M

    更新日期:2016-02-01 00:00:00

  • Changes in cytomorphology of childhood lymphoblastic leukaemia at the time of disease relapse. Childhood Leukaemia Working Party of the United Kingdom Medical Research Council.

    abstract:AIMS:Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the evolution of the disease. METHODS:Each relapse slide was assessed blindly for French American British (FAB) type and oth...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Lilleyman JS,Stevens RF,Hann IM,Gibson BE,Britton JA,Darbyshire PJ,Oakhill A

    更新日期:1995-11-01 00:00:00

  • Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas.

    abstract:AIM:The immunoproteasome is a specific proteasome isoform whose proteolytic activity enhances the generation of antigenic peptides to be presented by major histocompatibility complex class I molecules to CD8+ T cells. Physiologically, it is expressed abundantly in immune cells and is induced in somatic cells by cytokin...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Kiuchi T,Tomaru U,Ishizu A,Imagawa M,Iwasaki S,Suzuki A,Otsuka N,Ohhara Y,Kinoshita I,Matsuno Y,Dosaka-Akita H,Kasahara M

    更新日期:2020-09-17 00:00:00

  • Flow cytometry in diagnosis and management of large fetomaternal haemorrhage.

    abstract:AIMS:To evaluate an indirect immunofluorescence flow cytometry technique in a series of patients with large fetomaternal haemorrhage (FMH). METHODS:Patient samples identified by Kleihauer testing in local laboratories as having FMH > 4 ml were sent for flow cytometric analysis. In a proportion of cases the mothers rec...

    journal_title:Journal of clinical pathology

    pub_type: 临床试验,杂志文章


    authors: Johnson PR,Tait RC,Austin EB,Shwe KH,Lee D

    更新日期:1995-11-01 00:00:00

  • Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection.

    abstract:AIM:To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS:Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were gra...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Phull PS,Price AB,Stephens J,Rathbone BJ,Jacyna MR

    更新日期:1996-05-01 00:00:00

  • In situ hybridisation in formalin fixed, paraffin wax embedded liver specimens: method for detecting human and viral DNA using biotinylated probes.

    abstract::A rapid and reproducible technique for in situ hybridisation, using biotin labelled probes for the Y chromosome, human DNA, hepatitis B virus DNA and cytomegalovirus DNA on formalin fixed, paraffin embedded liver tissue, was developed. The degree of proteolytic digestion of tissue specimens is critical to ensure adequ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Naoumov NV,Alexander GJ,Eddleston AL,Williams R

    更新日期:1988-07-01 00:00:00

  • Langerhans' cell histiocytosis: possible association with malignant germ cell tumour.

    abstract::A rare case of adult onset Langerhans' cell histiocytosis associated with dysgerminoma in a 35 year old Chinese woman is reported. The patient had a history of dysgerminoma of left ovary 15 years previously and had undergone surgery followed by radiotherapy and an uneventful recovery. She presented again in March 1994...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Ng WK,Lam KY,Ng IO

    更新日期:1995-10-01 00:00:00

  • Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus.

    abstract:BACKGROUND:Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis. Morules have distinct histological characteristics, and are referred to as squamous metaplasia or squamoid metaplasia. AIM:To focus o...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Chinen K,Kamiyama K,Kinjo T,Arasaki A,Ihama Y,Hamada T,Iwamasa T

    更新日期:2004-09-01 00:00:00

  • Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report.

    abstract::Renal involvement as the first manifestation of sarcoidosis is rare and has never been reported in India. This report describes a 35 year old man who was admitted to the emergency department with a clinical diagnosis of acute on chronic renal failure, secondary to obstructive uropathy. Postmortem examination unexpecte...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Awasthi A,Nada R,Malhotra P,Goel R,Joshi K

    更新日期:2004-10-01 00:00:00

  • Evaluation of Questor urine screening system for bacteriuria and pyuria.

    abstract:AIMS:To evaluate the Questor automated bacteriuria and pyuria screening system; to compare its performance with that of a reference method; and to assess its usefulness in a routine clinical laboratory. METHODS:The Questor urine screening system was compared with a comprehensive regimen to detect urinary tract infecti...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Stevens M,Mitchell CJ,Livsey SA,MacDonald CA

    更新日期:1993-09-01 00:00:00

  • Histometry of lymphoid infiltrate in the thyroid of primary thyrotoxicosis patients. Relation of extent of thyroiditis to preoperative drug treatment and postoperative hypothyroidism.

    abstract::The thyroids of primary thyrotoxicosis patients prepared for partial thyroidectomy with propranolol contained much more lymphoid infiltrate than those prepared with carbimazole. No relation was found between the extent of lymphoid infiltrate in the thyroid and the development of postoperative hypothyroidism either bet...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Young RJ,Sherwood MB,Simpson JG,Nicol AG,Michie W,Beck JS

    更新日期:1976-05-01 00:00:00

  • Latex agglutination in the diagnosis of meningococcal meningitis.

    abstract::Group-specific polysaccharides of Neisseria meningitidis groups A and C have been demonstrated by means of a rapid, sensitive slide agglutination test with latex particles coated with antibodies. In this manner, the diagnosis can be made from the cerebrospinal fluid of patients with meningococcal meningitis caused by ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Severin WP

    更新日期:1972-12-01 00:00:00

  • Extramedullary transformation of chronic myeloid leukaemia with a unique chromosome pattern.

    abstract::A case of extramedullary myeloblastic transformation of chronic myeloid leukaemia is reported. This was characterised by an unusual clinical and haematological course and showed a unique cytogenetic pattern. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Flanagan NG,Harrison CJ,Harry DS,Ridway JC

    更新日期:1985-07-01 00:00:00

  • Nasal polyposis in Peutz-Jeghers syndrome: a distinct histopathological and molecular genetic entity.

    abstract:BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: de Leng WW,Westerman AM,Weterman MA,Jansen M,van Dekken H,Giardiello FM,de Rooij FW,Paul Wilson JH,Offerhaus GJ,Keller JJ

    更新日期:2007-04-01 00:00:00

  • Comparison of three methods for culture confirmation of Neisseria gonorrhoeae strains currently circulating in the UK.

    abstract:AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Turner A,Gough KR,Jephcott AE

    更新日期:1995-10-01 00:00:00

  • Histochemical demonstration of chymotrypsin like serine esterases in mucosal mast cells in four species including man.

    abstract::Serine esterases were detected in the granules of mucosal mast cells from rat, mouse, sheep, and man. Successful demonstration of enzyme activity required brief fixation (6 h) of tissues in 4% paraformaldehyde. Staining with naphthol AS-D chloroacetate produced an intense red reaction product in intraepithelial mucosa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Huntley JF,Newlands GF,Gibson S,Ferguson A,Miller HR

    更新日期:1985-04-01 00:00:00

  • Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.

    abstract:AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Montironi R,Valli M,Fabris G

    更新日期:1996-04-01 00:00:00

  • Plasma diamine oxidase levels in pregnancy complicated by threatened abortion.

    abstract::Plasma diamine oxidase levels were assayed in 66 patients who presented with pregnancy complicated by threatened abortion. Levels within the normal range were associated with continuing pregnancies, whereas levels below the normal range were associated with subsequent abortion. Among those patients in whom gestation w...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Legge M,Duff GB

    更新日期:1981-02-01 00:00:00

  • Morphometry of spermatozoa using semiautomatic image analysis.

    abstract::Human sperm heads were detected and tracked using semiautomatic image analysis. Measurements of size and shape on two specimens from each of 26 men showed that the major component of variability both within and between subjects was the number of small elongated sperm heads. Variability of the computed features between...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Jagoe JR,Washbrook NP,Hudson EA

    更新日期:1986-12-01 00:00:00

  • Antibodies specific for measles virus envelope antigens and autoantibodies in patients with chronic active hepatitis.

    abstract::Distinctly increased levels of antibodies to measles virus envelope antigens haemolysin and haemagglutinin were found in the sera of patients with chronic active hepatitis compared with a normal control group, using immunofluorescence and functional tests. Similarly, a higher incidence of smooth muscle antibody of bot...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Shirodaria PV,McMillan SA,Callender ME,Haire M,Fleming E,Merrett JD,Fulton TT

    更新日期:1985-11-01 00:00:00

  • Mucin histochemistry of mucous carcinomas of breast and colon and non-neoplastic breast epithelium.

    abstract::Although epithelial mucin has been demonstrated in ordinary mammary duct carcinomas, it is formed profusely in the uncommon mucous carcinomas. A histochemical study of mucous carcinomas of the breast and colon showed that both types produce similar mucins, viz, acid and neutral, although the mammary carcinomas produce...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Cooper DJ

    更新日期:1974-04-01 00:00:00

  • Analysis of von Willebrand factor multimers using a commercially available enhanced chemiluminescence kit.

    abstract:AIMS:To develop a rapid, sensitive, and safe method for the analysis of von Willebrand factor (vWf) multimers in plasma or platelet lysates. METHOD:Analysis of vWf multimers was carried out by sodium dodecyl sulphate-agarose discontinuous gel electrophoresis followed by protein transfer to nitrocellulose membranes by ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Cumming AM,Wensley RT

    更新日期:1993-05-01 00:00:00

  • Automatic platelet counting with the Couler particle counter.

    abstract::A method for accurately counting platelets is described using the Coulter counter model B fitted with a standard 100mu aperture tube. This enables the counter to be used for red and white cell as well as platelet counts using the same aperture tube. The method uses standard equipment except for a small inexpensive ele...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Davis RE,Green RE

    更新日期:1967-09-01 00:00:00

  • An evaluation of Neisseria gonorrhoeae antimicrobial susceptibility testing in the UK.

    abstract::The only method currently available to perform Neisseria gonorrhoeae antimicrobial susceptibility testing (Ng-AST) requires a viable organism obtained by culture. Reports of in vitro resistance to extended-spectrum cephalosporins, the treatment of choice for gonorrhoea, coupled with increasing gonorrhoea diagnoses is ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Jain A,Cole MJ,Planche T,Ison CA

    更新日期:2014-11-01 00:00:00

  • Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments.

    abstract:BACKGROUND:Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4+ T-cells. AIMS:To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T(H) immune response i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Atayar C,van den Berg A,Blokzijl T,Boot M,Gascoyne RD,Visser L,Poppema S

    更新日期:2007-10-01 00:00:00