Plastic embedded core biopsy: a complementary approach to bone marrow aspiration for diagnosing acute myeloid leukaemia.


:Bone marrow aspirates and biopsy specimens were taken at diagnosis from 51 patients with acute myeloid leukaemia (AML). The diagnosis was based on morphological and cytochemical analyses, and the leukaemias were classified by FAB criteria. A considerable difference was observed between the results of bone marrow aspirates and the findings of plastic-embedded bone marrow biopsy specimens, particularly in marrow cellularity, extent of blast cell infiltration, and cell type involved in the leukaemic process. The myelomonocytic cell type seemed to predominate in the sections. In four cases there was considerable marrow infiltration with maturing, but dysplastic, granulocytic cells in the sections, but not in the aspirate smears. Features of potential prognostic importance, such as bone marrow infiltration with inflammatory cells, were easily recognised and quantified in the sections. These results indicate that plastic embedded bone marrow biopsy sections complement the findings of bone marrow aspiration in the diagnosis of AML and may also provide information of independent prognostic importance that cannot be obtained by other means.


J Clin Pathol


Islam A,Frisch B,Henderson ES




Has Abstract


1989-03-01 00:00:00












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  • Front-end genomics: using an alternative approach for the recovery of high-quality DNA from core needle biopsies.

    abstract:AIMS:Determine whether a simple prewash step will provide adequate amounts of high-quality DNA from core needle biopsies for molecular sequencing studies. METHODS:The quantitative and qualitative metrics of DNA recovered from core needle biopsies processed either by 1) formalin fixation and paraffin embedding (FFPE), ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Mojica WD,Hou T,Sykes D,Dey-Rao R

    更新日期:2017-06-01 00:00:00

  • Rapid serotyping of groups A, B, and C meningococci by rocket-line immunoelectrophoresis and co-agglutination.

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    journal_title:Journal of clinical pathology

    pub_type: 杂志文章


    authors: Danielsson D,Olcén P

    更新日期:1979-02-01 00:00:00

  • Cytomegalovirus infections in heart and heart and lung transplant recipients.

    abstract::Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%...

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    authors: Wreghitt TG,Hakim M,Gray JJ,Kucia S,Wallwork J,English TA

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    abstract::Laboratory studies on clotrimazole showed that it had marked activity in vitro against all the Candida spp. and Cryptococcus spp. tested, against almost all strains of dermatophytes, and against Aspergillus spp and other fungal genera responsible for systemic mycoses; it had limited activity towards Gram-positive bact...

    journal_title:Journal of clinical pathology

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    journal_title:Journal of clinical pathology

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    pub_type: 杂志文章



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    pub_type: 杂志文章


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