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Undiagnosed cognitive impairment, health status and depressive symptoms in patients with type 2 diabetes.

Abstract：

AIMS:Type 2 diabetes (T2DM) is associated with cognitive impairment. We examined whether undiagnosed cognitive impairment in T2DM-patients is associated with a reduced health status and depressive symptoms. METHODS:In an observational study, 225 T2DM-patients aged ≥70years were examined at their homes and (some of them) at a memory clinic for undiagnosed cognitive impairment (dementia or mild cognitive impairment [MCI], defined according to internationally accepted criteria). Questionnaires assessing health status (SF-36, EQ-5D, EQ-VAS) and depressive symptoms (CES-D) were filled out. Health status and depressive symptoms were compared between patients with and without cognitive impairment. RESULTS:Patients with cognitive impairment (n=57) showed significantly lower scores on the physical and mental summary scores of the SF-36 than patients with normal cognition (difference: 3.5 (95%-CI 0.7-6.3, p=0.02, effect size 0.41) and 2.9 (95%-CI 0.3-5.6; p=0.03, effect size 0.37). EQ-5D index and EQ-VAS scores were significantly lower in patients with cognitive impairment. Depression (CES-D≥16) occurred almost twice as often in patients with cognitive impairment (RR 1.8; 95%-CI: 1.1-3.0). CONCLUSIONS:Undiagnosed cognitive impairment in T2DM-patients is associated with a reduced health status and more depressive symptoms. Detection of cognitive impairment in T2DM-patients identifies a vulnerable patient group that could benefit from tailored treatment and care.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Koekkoek PS,Biessels GJ,Kooistra M,Janssen J,Kappelle LJ,Rutten GE,Cog-ID study group.

doi

10.1016/j.jdiacomp.2015.07.010

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1217-22

issue

8

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(15)00282-2

journal_volume

29

pub_type

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