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Lixisenatide plus basal insulin in patients with type 2 diabetes mellitus: a meta-analysis.

Abstract：

AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/without OADs. The primary endpoint was change in HbA1c from baseline to week 24. Secondary endpoints were change in PPG, FPG, insulin dose, and weight from baseline to week 24. Hypoglycemia rates and several composite endpoints were assessed. RESULTS:Lixisenatide plus basal insulin was significantly more effective than basal insulin alone at reducing HbA1c at 24 weeks. Composite and secondary endpoints were improved significantly with lixisenatide plus basal insulin, with the exception of FPG, which showed no significant difference between the groups. Lixisenatide plus basal insulin was associated with an increased incidence of hypoglycemia versus basal insulin alone. CONCLUSIONS:Lixisenatide plus basal insulin resulted in significant improvement in glycemic control versus basal insulin alone, particularly in terms of controlling PPG. Prandial lixisenatide in combination with basal insulin is a suitable option for treatment intensification in patients with T2DM insufficiently controlled with basal insulin, as these agents have complementary effects on PPG and FPG, respectively.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Charbonnel B,Bertolini M,Tinahones FJ,Domingo MP,Davies M

doi

10.1016/j.jdiacomp.2014.07.007

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

880-6

issue

6

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(14)00207-4

journal_volume

28

pub_type

杂志文章,meta分析

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