A prospective study of cardiovascular disease in patients with Type 2 diabetes. 6.3 years of follow-up.

Abstract:

OBJECTIVE:Type 2 diabetes mellitus (DM-2) is an important cardiovascular risk factor, although hardly any data are available in our country. Therefore, we decided to study the incidence of cardiovascular disease (CVD) and the related variables with its appearance in a group of patients with DM-2. RESEARCH DESIGN AND METHODS:176 DM-2 patients without CVD at baseline (63.6% women, mean age 54+/-8.9), mean follow-up 6.3 years. We collected data at 6-month intervals concerning new micro- and macrovascular complications, glucose, HbA(1C), lipid profile, and renal function. We analyzed values at baseline and at the end of follow-up. For numeric variables, the mean value during follow-up was calculated. In renal function variables, we also worked out the difference between baseline and final values, considering the time until the first episode of CVD as the independent variable. Kaplan-Meier analysis was used in categorical variables and Cox regression tests for numeric data and also for multivariate analysis. In multivariate analysis, we included significant data in the univariate analysis, excluding those from the end of the follow-up with the aim of having some predictive meaning in our results. RESULTS:New episodes of CVD were detected in 28 patients (15.9%). These events were statistically related with baseline diagnosed hypertension, presence of diabetic nephropathy and retinopathy, HbA(1C), and total cholesterol. Among mean values during follow-up, the association was with HbA(1C), cholesterol, urinary albumin excretion rate (UAER), glomerular filtration rate (GFR), and systolic arterial pressure. There was also a relationship of CVD events with the new appearance or worsening of diabetic retinopathy or nephropathy, creatinine and UAER increase and the decrease of GFR and effective renal plasma flow (ERPF), during follow-up. In the multivariate analysis, we found an independent association with the appearance of CVD and mean HbA(1C), mean UAER and the presence of proliferative diabetic retinopathy at baseline. CONCLUSIONS:We have a rather low incidence of CVD in our patients with DM-2. The appearance of CVD is independently related with HbA(1C), the level of UAER, and the presence at baseline of diabetic retinopathy.

authors

Rius Riu F,Salinas Vert I,Lucas Martín A,Romero González R,Sanmartí Sala A

doi

10.1016/s1056-8727(02)00174-5

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

235-42

issue

5

eissn

1056-8727

issn

1873-460X

pii

S1056872702001745

journal_volume

17

pub_type

杂志文章
  • Retrospective analysis of safety and efficacy of liraglutide monotherapy and sulfonylurea-combination therapy in Japanese type 2 diabetes: Association of remaining β-cell function and achievement of HbA1c target one year after initiation.

    abstract:AIMS:The GLP-1 receptor agonist liraglutide improves impaired pancreatic β-cell function, thereby exerting glucose-lowering effects. However, the association of remaining β-cell function with long-term therapeutic efficacy of liraglutide remains largely unknown. METHODS:Patients with type 2 diabetes who started liragl...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2015.07.020

    authors: Usui R,Yabe D,Kuwata H,Murotani K,Kurose T,Seino Y

    更新日期:2015-11-01 00:00:00

  • Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes.

    abstract:OBJECTIVES:Controversy remains as to the effects of type 2 diabetes on bone metabolism. The aims of this study were to assess the association between type 2 diabetes and bone mineral density (BMD) and to evaluate the possible relationship between chronic diabetic complications and bone density. METHODS:Bone mineral de...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2007.06.004

    authors: Anaforoglu I,Nar-Demirer A,Bascil-Tutuncu N,Ertorer ME

    更新日期:2009-01-01 00:00:00

  • The role of the high-mobility group box1 protein-Toll like receptor pathway in diabetic vascular disease.

    abstract:OBJECTIVES:Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in increased cellular inflammation. Since we have shown increased TLR2 and 4 activities in both T1DM and T2DM and MetS, we wanted to elucidate the mechanisms of this ste...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2016.03.005

    authors: Pahwa R,Jialal I

    更新日期:2016-08-01 00:00:00

  • The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans.

    abstract:OBJECTIVE:The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA). RESEARCH DESIGN AND METHODS:Data from the Insulin Resistance Atheroscl...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.10.018

    authors: Young KA,Maturu A,Lorenzo C,Langefeld CD,Wagenknecht LE,Chen YI,Taylor KD,Rotter JI,Norris JM,Rasouli N

    更新日期:2019-02-01 00:00:00

  • Early changes of arterial elasticity in Type 1 diabetes with microvascular complications - A cross-sectional study from childhood to adulthood.

    abstract:AIM:To examine the trajectory of small artery elasticity (SAE) and pulse pressure (PP) in people with Type 1 diabetes and non-diabetic controls across the lifespan, and explore associations with microvascular complications (CX+). METHODS:This cross-sectional study included 477 Type 1 diabetes patients (188 with CX+, 2...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jdiacomp.2017.08.007

    authors: Benitez-Aguirre PZ,Januszewski AS,Cho YH,Craig ME,Jenkins AJ,Donaghue KC

    更新日期:2017-12-01 00:00:00

  • Measurement of gastric emptying in diabetes.

    abstract::There has been a substantial evolution of concepts related to disordered gastric emptying in diabetes. While the traditional focus has hitherto related to the pathophysiology and management of upper gastrointestinal symptoms associated with gastroparesis, it is now apparent that the rate of gastric emptying is central...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2014.06.005

    authors: Phillips LK,Rayner CK,Jones KL,Horowitz M

    更新日期:2014-11-01 00:00:00

  • Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus.

    abstract:OBJECTIVES:Metformin is widely used in patients with type 2 diabetes but may decrease vitamin B(12) levels and increase levels of homocysteine (Hcy), a cardiovascular risk factor. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, may reduce markers of inflammation. We investigated whether 6 wee...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2005.10.005

    authors: Sahin M,Tutuncu NB,Ertugrul D,Tanaci N,Guvener ND

    更新日期:2007-03-01 00:00:00

  • The relative associations of β-cell function and insulin sensitivity with glycemic status and incident glycemic progression in migrant Asian Indians in the United States: the MASALA study.

    abstract:AIMS:We assessed the relative associations of β-cell dysfunction and insulin sensitivity with baseline glycemic status and incident glycemic progression among Asian Indians in the United States. METHODS:A 5-sample oral glucose tolerance test was obtained at baseline. Normoglycemia, impaired fasting glucose (IFG), impa...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.10.002

    authors: Gujral UP,Narayan KM,Kahn SE,Kanaya AM

    更新日期:2014-01-01 00:00:00

  • Plasma brain natriuretic peptide levels in normotensive Type 2 diabetic patients without cardiac disease and macroalbuminuria.

    abstract::To clarify the relationship of the plasma brain natriuretic peptide (BNP) levels to diabetic complications, we studied plasma BNP levels in 100 normotensive diabetic patients without clinical cardiac disease and macroalbuminuria. The values of plasma BNP levels were not significantly different between patients with mi...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(01)00173-8

    authors: Asakawa H,Fukui T,Tokunaga K,Kawakami F

    更新日期:2002-05-01 00:00:00

  • Mortality risk in admitted patients with diabetes mellitus according to treatment.

    abstract:AIMS:Investigate the importance of treating diabetes by evaluating mortality risk of untreated and medically-treated diabetic patients. METHODS:Historical prospectively collected observational data of hospitalized patient ≥18years, admitted for any-cause to medical wards, between January 2011 and December 2013. Main o...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.04.011

    authors: Akirov A,Dicker D,Shochat T,Shimon I

    更新日期:2016-08-01 00:00:00

  • Community-acquired infections in type 2 diabetic patients and their nondiabetic partners. The Fremantle Diabetes Study.

    abstract:AIMS:The aim of this study was to investigate the association between Type 2 diabetes and community-acquired infections. METHODS:We recruited 68 patients (mean+/-S.D. age=64.9+/-9.1 years; 57.4% males) from a community-based cohort and their nondiabetic partners (age=63.8+/-9.9 years; mean relationship duration=37.3+/...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2005.03.003

    authors: Davis TM,Weerarathne T,Foong Y,Mason C,Davis WA

    更新日期:2005-09-01 00:00:00

  • Long-term effects of antihypertensive treatment and good glycemic control on plasma lipids in diabetic rats.

    abstract::The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(94)00045-p

    authors: Reddi AS,Jyothirmayi GN,Bollineni JS

    更新日期:1995-07-01 00:00:00

  • Glycemic control is an important modifiable risk factor for uveitis in patients with diabetes: A retrospective cohort study establishing clinical risk and ophthalmic disease burden.

    abstract:AIM:To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS:Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis o...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.03.008

    authors: Ansari AS,de Lusignan S,Hinton W,Munro N,Taylor S,McGovern A

    更新日期:2018-06-01 00:00:00

  • Improved treatment satisfaction in patients with type 1 diabetes treated with insulin glargine 100U/mL versus neutral protamine Hagedorn insulin: An exploration of key predictors from two randomized controlled trials.

    abstract:AIM:Investigate contributors to treatment satisfaction in type 1 diabetes (T1D). METHODS:Post-hoc analysis using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) in 771 T1D patients from two 28-week trials comparing once-daily insulin glargine 100U/mL (Gla-100) with once- or twice-daily NPH neu...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.11.018

    authors: Polonsky W,Traylor L,Gao L,Wei W,Ameer B,Stuhr A,Vlajnic A

    更新日期:2017-03-01 00:00:00

  • Taurine prevents galactose-induced cataracts.

    abstract::Intact lenses from New Zealand white rabbits were incubated in tissue culture media containing either 5 mM glucose or 5 mM glucose plus 30 mM galactose. The standard media did not contain taurine. Lenses were also cultured in a third medium containing 30 mM galactose plus 0.2 mM taurine. The frequency of cataract form...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(93)90023-r

    authors: Malone JI,Benford SA,Malone J Jr

    更新日期:1993-01-01 00:00:00

  • Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes: acute postprandial and chronic effects on glycemic control and cardiovascular risk factors.

    abstract:OBJECTIVE:Two insulin regimens were used to explore acute and chronic postprandial changes in glycemia, lipemia, and metabolic markers associated with increased risk of cardiovascular disease. METHODS:An open-label, randomized, two-period crossover study (12 weeks/period) compared a prandial regimen [premeal insulin l...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2005.11.005

    authors: Ceriello A,Del Prato S,Bue-Valleskey J,Beattie S,Gates J,de la Peña A,Malone J

    更新日期:2007-01-01 00:00:00

  • Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM.

    abstract::To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associations with diabetes-associated microvascular dermatoses (DAMD). Further, to analyze the distribution of individual genotype combinations on the particular polymorphic loci in ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(00)00135-5

    authors: Kanková K,Záhejský J,Márová I,Muzík J,Kuhrová V,Blazková M,Znojil V,Beránek M,Vácha J

    更新日期:2001-07-01 00:00:00

  • Does treatment affect the levels of serum interleukin-6, interleukin-8 and procalcitonin in diabetic foot infection? A pilot study.

    abstract:AIMS:To investigate about serum PCT, IL-6 and IL-8 levels and how they are affected by the treatment in diabetic foot patients. METHODS:Fifty patients' blood samples were taken to study ESR and CRP, IL-6, IL-8 and PCT before and at the 14th day of the treatment. RESULTS:The pretreatment results of the 50 patients sho...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jdiacomp.2012.03.018

    authors: Altay FA,Sencan İ,Şentürk GÇ,Altay M,Güvenman S,Ünverdi S,Açıkgöz ZC

    更新日期:2012-05-01 00:00:00

  • Seasonal variability of glycated hemoglobin in a diabetic population from southern Europe.

    abstract:AIMS:To analyze the seasonal variations in A1c levels among a southern European diabetic population. METHODS:We examined all monthly-grouped A1c determinations from diabetic patients during the period 2006-2011, in a region of southern Spain. RESULTS:There were 61,329 records available. The mean A1c value was 56mmol/...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.04.013

    authors: Gomez-Huelgas R,Santamaria-Fernandez S,Guijarro-Merino R,Navajas-Luque F,Tinahones FJ,Roman-Teran CM,Picon MJ,Bernal-Lopez MR

    更新日期:2013-11-01 00:00:00

  • Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes.

    abstract:BACKGROUND:Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2016.10.003

    authors: Scalzo RL,Moreau KL,Ozemek C,Herlache L,McMillin S,Gilligan S,Huebschmann AG,Bauer TA,Dorosz J,Reusch JE,Regensteiner JG

    更新日期:2017-02-01 00:00:00

  • Differentially methylated circulating DNA: A novel biomarker to monitor beta cell death.

    abstract::Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2017.08.012

    authors: Liu Y,Tan Q,Liu F

    更新日期:2018-03-01 00:00:00

  • Human C-reactive protein accentuates macrophage activity in biobreeding diabetic rats.

    abstract:OBJECTIVE:Type 1 diabetes (T1DM) is a pro-inflammatory state characterized by high C-reactive protein (CRP) levels. However, there is a paucity of data examining the role of CRP in promoting the pro-inflammatory state of diabetes. Thus, we examined the pro-inflammatory effects of human CRP using spontaneously diabetic ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2012.03.020

    authors: Jialal I,Kaur H,Devaraj S

    更新日期:2013-01-01 00:00:00

  • Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.

    abstract::The relationship between the effect of aldose reductase inhibitors (ARIs) on the activation of the polyol pathway and on diabetic neuropathy has not been fully established. To address this issue, we investigated the effect of epalrestat (150 mg/day), an ARI, on erythrocyte sorbitol levels as an index of polyol activat...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jdiacomp.2005.09.002

    authors: Ando H,Takamura T,Nagai Y,Kaneko S,Kanazawa University Multicenter Diabetes Study Group.

    更新日期:2006-11-01 00:00:00

  • Lixisenatide plus basal insulin in patients with type 2 diabetes mellitus: a meta-analysis.

    abstract:AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jdiacomp.2014.07.007

    authors: Charbonnel B,Bertolini M,Tinahones FJ,Domingo MP,Davies M

    更新日期:2014-11-01 00:00:00

  • Associations between long chain polyunsaturated fatty acids and cardiovascular lipid risk factors in youth with type 1 diabetes: SEARCH Nutrition Ancillary Study.

    abstract:PURPOSE:In this longitudinal study we explored the relationships between plasma n-3 and n-6 polyunsaturated fatty acids (PUFAs) and Δ5 and Δ6 desaturase activities (D5D and D6D, respectively) and fasting lipids in youth with type 1 diabetes (T1D). METHODS:Incident cases of T1D in youth <20years of age who were seen fo...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2016.10.002

    authors: Couch SC,Crandell J,King I,Peairs A,Shah AS,Dolan LM,Tooze J,Crume T,Mayer-Davis E

    更新日期:2017-01-01 00:00:00

  • Association of urinary acidification function with the progression of diabetic kidney disease in patients with type 2 diabetes.

    abstract:OBJECTIVE:Although diabetic kidney disease (DKD) has been considered as a glomerulocentric disease in the past few decades, growing evidence demonstrated that tubular damage was indispensable in its pathogenesis and progression. This study was designed to investigate the association of urinary acidification dysfunction...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.107419

    authors: Zhu H,Liu X,Zhang C,Li Q,An X,Liu S,Wu L,Zhang B,Yuan Y,Xing C

    更新日期:2019-11-01 00:00:00

  • PAX4 R192H is associated with younger onset of Type 2 diabetes in East Asians in Singapore.

    abstract:AIMS:Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly,...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.10.002

    authors: Ang SF,Tan CSH,Wang L,Dorajoo R,Fong JCW,Kon WYC,Lian JX,Ang K,Rahim JB,Jeevith B,Lee SBM,Tang WE,Subramanium T,Sum CF,Liu JJ,Lim SC

    更新日期:2019-01-01 00:00:00

  • Patients with type 2 diabetes having higher glomerular filtration rate showed rapid renal function decline followed by impaired glomerular filtration rate: Japan Diabetes Complications Study.

    abstract:AIMS:The Japan Diabetes Complications Study (JDCS), a nation-wide, multicenter, prospective study of patients with type 2 diabetes, reported that hemoglobin A1c (HbA1c), systolic blood pressure, and smoking were risk factors for the onset of macroalbuminuria. This study explored the risk factors for glomerular filtrati...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jdiacomp.2016.06.020

    authors: Moriya T,Tanaka S,Sone H,Ishibashi S,Matsunaga S,Ohashi Y,Akanuma Y,Haneda M,Katayama S

    更新日期:2017-02-01 00:00:00

  • Lower extremity amputations in diabetic Mexican American elders: incidence, prevalence and correlates.

    abstract::This study was designed to determine the incidence and prevalence of amputations in diabetic Mexican American elders and to identify correlates of lower extremity amputations. Data for this study came from baseline and two follow-up interviews of the Hispanic Established Population for the Epidemiological Study of the...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(02)00175-7

    authors: Otiniano ME,Du X,Ottenbacher K,Black SA,Markides KS

    更新日期:2003-03-01 00:00:00

  • The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study.

    abstract:INTRODUCTION:Diabetic polyneuropathy aetiology is based on oxidative stress generation due to production of reactive oxygen species. Ubiquinone is reduced to ubiquinol and redistributed into lipoproteins, possibly to protect them from oxidation. AIMS:To evaluate the impact of oral ubiquinone in diabetic polyneuropathy...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2012.04.004

    authors: Hernández-Ojeda J,Cardona-Muñoz EG,Román-Pintos LM,Troyo-Sanromán R,Ortiz-Lazareno PC,Cárdenas-Meza MA,Pascoe-González S,Miranda-Díaz AG

    更新日期:2012-07-01 00:00:00