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The change in one-hour postload plasma glucose levels, and an analysis of its related factors in abdominally obese Han Chinese men with normal glucose tolerance.

Abstract：

OBJECTIVE:This study was to observe the difference in one-hour postload plasma glucose levels and analyze its related factors in abdominally obese men with normal glucose tolerance (NGT). DESIGN:This case-control study included 36 abdominally obese men (waist circumference ≥90 cm) and 31 non-abdominally obese men (waist circumference <90 cm) aged 20-50 years with NGT. Cases and controls were matched in age. All subjects underwent oral glucose tolerance test with 75 g of oral anhydrous glucose. RESULTS:0.5 and 1-h postload plasma glucose levels were higher in abdominally obese group than in non-abdominally obese group (P<.05). Fasting plasma glucose (FPG), 2 and 3-h postload plasma glucose were similar in the two groups (P>.05). 1-h postload plasma glucose was positively correlated with body mass index (r=0.454), waist circumference (WC) (r=0.519), systolic blood pressure (r=0.456), diastolic blood pressure (r=0.338), triglycerides (r=0.439), and negatively correlated with high density lipoprotein cholesterol (r=-0.391), 1/fasting insulin (r=-0.459), insulinogenic index (r=-0.357) and disposition index (r=-0.602) (P<.01). In multiple regression analysis, 1-h postload plasma glucose maintained an independent association with disposition index (β=-1.367, P=.000), WC (β=0.103, P=.000) and triglycerides (β=0.185, P=.017). CONCLUSIONS:The present study demonstrated that the level of one-hour postload plasma glucose was elevated in abdominally obese men with NGT. Besides FPG and 2-h postload plasma glucose, we must also pay attention to the measurement of one-hour postload plasma glucose. Disposition index, WC and triglycerides were independently related factors for elevated one-hour postload plasma glucose.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Qin CM,Wang R,Yin FZ,Liu B,Ma CM,Lu Q

doi

10.1016/j.jdiacomp.2012.05.022

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

536-9

issue

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(12)00176-6

journal_volume

pub_type

杂志文章

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The change in one-hour postload plasma glucose levels, and an analysis of its related factors in abdominally obese Han Chinese men with normal glucose tolerance.