Abstract：
:We examined the potential of astemizole, a histamine H1-receptor antagonist that does not cross the blood-brain barrier, to reverse blood-retinal barrier leakage to albumin in streptozotocin diabetic rats. Four groups of nondiabetic and four groups of diabetic rats received vehicle or astemizole at dosages of 5, 10, or 20 mg/kg body weight for days 22-28 of a 28-day holding period. There were no significant differences in nondiabetic plasma-vitreous albumin ratios between animals receiving vehicle or any of the three astemizole dosages. Only diabetic rats receiving vehicle showed a significant (p < 0.05) 100% increase in the plasma-vitreous albumin ratio over their nondiabetic counterparts. Diabetic rats receiving either 5, 10, or 20 mg/kg astemizole exhibited total normalization of vitreous albumin accumulation, despite persistence of diabetes. These data indicate that astemizole, an H1-receptor antagonist that does not cross the blood-retinal barrier, is effective in reversing blood-retinal barrier leakage of albumin in experimental diabetes.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Hollis TM,Sill HW,Butler C,Campos MJ,Gardner TWdoi
10.1016/1056-8727(92)90057-rkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
230-5issue
4eissn
1056-8727issn
1873-460Xpii
1056-8727(92)90057-Rjournal_volume
6pub_type
杂志文章abstract：AIM:To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status. METHODS:In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.05.004
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:There are no large studies in Type 1 diabetic patients that have examined the relation between soluble adhesion molecules and micro- and macrovascular outcomes, although the risks of such complications are high. Therefore, the main objective is to examine the relationship between soluble (s) vascular cell adh...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2005.06.005
更新日期：2006-05-01 00:00:00
abstract：AIMS:Increased adiposity is a risk factor for suboptimal diabetes control and cardiovascular disease (CVD) complications. Our goal was to identify modifiable behavioral characteristics of overweight and obese pediatric patients with type 1 diabetes mellitus (T1DM) who achieve optimal glycemic control and to evaluate th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.107513
更新日期：2020-04-01 00:00:00
abstract：:Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(00)00069-6
更新日期：2000-03-01 00:00:00
abstract：:Diabetes is associated with a high level of mortality due to cardiovascular disease resulting from accelerated coronary artery atherosclerosis. A current focus for investigation of atherosclerotic mechanisms is the vascular endothelium since physical or functional injury may represent an initiating step for atherogene...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(01)00141-6
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:The notion of combining immunomodulatory agents with the incretin exendin-4 (Ex-4) has seen considerable favor as a potential therapy for the reversal of type 1 diabetes in man. While the addition of Ex-4 provides modest improvement to the effectiveness of immunological-based monotherapies in reversing hyperg...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2008.12.004
更新日期：2010-05-01 00:00:00
abstract：AIMS:To investigate the discontinuation of oral antihyperglycemic agents (OHA), and examine factors associated with OHA discontinuation, and the effect of OHA discontinuation on glycemic control and healthcare utilization among diabetes patients prescribed dual OHA therapy. METHODS:We identified 23,612 adult patients ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.07.021
更新日期：2016-01-01 00:00:00
abstract：AIMS:To investigate the relationship of unawareness of hypoglycemia with spectral analysis of heart rate variability (HRV) and clinical variables in type 1 diabetes (T1D) individuals. METHODS:Participants with type 1 diabetes mellitus (type 1 diabetes) were prospectively assessed for hypoglycemia awareness using the P...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2020.107617
更新日期：2020-08-01 00:00:00
abstract：AIMS:Type 2 diabetes (T2DM) is associated with cognitive impairment. We examined whether undiagnosed cognitive impairment in T2DM-patients is associated with a reduced health status and depressive symptoms. METHODS:In an observational study, 225 T2DM-patients aged ≥70years were examined at their homes and (some of the...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.07.010
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:The use of safe iodinated contrast media (CM) to prevent contrast-induced nephropathy (CIN) is an important consideration among renally impaired diabetic patients during coronary angiography. HYPOTHESIS:Diabetic patients with normal or mild renal dysfunction are less likely to receive renal protective measu...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2006.11.002
更新日期：2008-05-01 00:00:00
abstract：AIMS:To examine the effects of strict glycemic control on the birthweight of infants born to Japanese patients with early- or mid-to-late-detected gestational diabetes mellitus (ed- or md-GDM). METHODS:We retrospectively examined the characteristics of 101 patients with GDM who underwent guideline-based glycemic contr...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2021.107850
更新日期：2021-01-09 00:00:00
abstract：AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.07.017
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:In this longitudinal study we explored the relationships between plasma n-3 and n-6 polyunsaturated fatty acids (PUFAs) and Δ5 and Δ6 desaturase activities (D5D and D6D, respectively) and fasting lipids in youth with type 1 diabetes (T1D). METHODS:Incident cases of T1D in youth <20years of age who were seen fo...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.10.002
更新日期：2017-01-01 00:00:00
abstract：AIMS:The Diabetes Complications Severity Index (DCSI) converts diagnostic codes and laboratory results into a 14-level metric quantifying the long-term effects of diabetes on seven body systems. Adoption of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) necessitates tran...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.02.018
更新日期：2017-06-01 00:00:00
abstract：:The thickening of alveolar basement membrane is found in autopsies, along with microvascular pathologies, in Type 1 and 2 diabetes mellitus (DM). To detect the function and permeability of alveolar basement membrane, carbon monoxide diffusion capacity (DLCO) and technetium 99m-diethyltriaminepentaaceticacid ((99m)Tc-D...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2005.07.003
更新日期：2006-07-01 00:00:00
abstract：AIM:To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS:Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.03.008
更新日期：2018-06-01 00:00:00
abstract：AIMS:The Japan Diabetes Complications Study (JDCS), a nation-wide, multicenter, prospective study of patients with type 2 diabetes, reported that hemoglobin A1c (HbA1c), systolic blood pressure, and smoking were risk factors for the onset of macroalbuminuria. This study explored the risk factors for glomerular filtrati...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jdiacomp.2016.06.020
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to investigate the relationship between plasma NH2-terminal pro-brain natriuretic peptide (NT-proBNP) levels and diabetic nephropathy in type 2 diabetic patients. METHODS:The records of 983 patients with type 2 diabetes hospitalized in the Endocrinology and Metabolism Department of P...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.01.017
更新日期：2016-05-01 00:00:00
abstract：:Diabetic retinopathy resists arrest of its progression after reestablishment of good glycemic control that follows a profound period of poor glycemic control. The objective of this study was to elucidate the role of inflammation in the resistance of retinopathy to arrest after termination of hyperglycemia. Streptozoto...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2008.10.002
更新日期：2010-01-01 00:00:00
abstract：:To clarify the influence of blood glucose level or diabetes mellitus on serum KL-6, a mucin-like glycoprotein, concentrations, they were measured against 176 diabetic subjects, including receiving insulin (INS) group (n=54), oral antidiabetics (OAD) group (n=78), and diet and exercise (D&E) group (n=44). Serum KL-6 co...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(01)00220-3
更新日期：2002-09-01 00:00:00
abstract：AIMS:To investigate the renal pathological implications in type 2 diabetes mellitus patients with renal involvement. METHODS:A total of 328 type 2 diabetes mellitus (T2DM) patients with renal involvement who underwent a renal biopsy and received follow-up for at least one year were recruited in our study. The patients...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.10.024
更新日期：2017-01-01 00:00:00
abstract：:A changed vasomotor reactivity of renal arteries may lead to defect autoregulation of renal hemodynamics with damage of diabetic kidneys. Eleven streptozotocin-induced diabetic male Wistar rats were daily treated with insulin in order to achieve a blood glucose of 21 mmol/L. Seventeen age and gender-matched rats serve...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(96)00041-4
更新日期：1997-09-01 00:00:00
abstract：AIMS:This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D). METHODS:12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox pr...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2013.06.005
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:Hyperglycemia-induced inflammation is central to the vascular complications in diabetes. Toll-like receptors (TLRs) are key players in regulating inflammatory responses. There are sparse data on the role of TLR2 and TLR4 in regulating human macrovascular aortic endothelial cells (HMAECs) inflammation and gly...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.01.014
更新日期：2016-05-01 00:00:00
abstract：:Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship betw...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.05.023
更新日期：2019-09-01 00:00:00
abstract：:The purpose of this study was to evaluate the mortality experience of persons with longstanding diabetes who had received pituitary irradiation for diabetic retinopathy compared to a matched group of persons with diabetes who had not had pituitary ablation. The irradiated cohort consisted of 167 patients treated at th...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/s1056-8727(97)00124-4
更新日期：1998-09-01 00:00:00
abstract：:Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. The increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the MI depletion found in the diabetic complications. The aim was to investigate whether single n...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.09.005
更新日期：2010-11-01 00:00:00
abstract：:This study was designed to determine the incidence and prevalence of amputations in diabetic Mexican American elders and to identify correlates of lower extremity amputations. Data for this study came from baseline and two follow-up interviews of the Hispanic Established Population for the Epidemiological Study of the...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(02)00175-7
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:This meta-analysis was conducted to assess the association between diabetes mellitus and periodontal diseases by comparing the extent and severity of periodontal diseases between diabetics and nondiabetics. METHODS:A literature search was performed using MEDLINE database for published studies from January 1...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,meta分析
doi：10.1016/j.jdiacomp.2005.05.006
更新日期：2006-01-01 00:00:00
abstract：:Tamm-Horsfall protein (THP), a glycoprotein produced in the thick ascending limb (TAL) and the early distal convoluted tubule (DCT), is normally excreted in large amounts in urine. Urinary THP may be a useful marker for renal damage. The goal of this research project was to determine the THP excretion in control and d...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(99)00046-x
更新日期：1999-07-01 00:00:00
