Abstract：
:The thickening of alveolar basement membrane is found in autopsies, along with microvascular pathologies, in Type 1 and 2 diabetes mellitus (DM). To detect the function and permeability of alveolar basement membrane, carbon monoxide diffusion capacity (DLCO) and technetium 99m-diethyltriaminepentaaceticacid ((99m)Tc-DTPA) aerosol scintigraphy methods can be used. The aim of this study was to determine alveolar basement membrane damage using these two methods. Nineteen women and 6 men, nonsmoking, Type 2 DM cases, without any lung and/or heart disease and who had neither anemia nor obesity, made up the patient group. They were compared with six female and nine male healthy cases who had the same characteristics with the diabetes cases. All of the cases DLCO were measured by single-breath method and (99m)Tc-DTPA aerosol scintigraphy was performed. DLCO showed no difference between the two groups. Aerosol scintigraphy was significantly decreased in the diabetic group (P=.01). In cases with >5 years of diabetic duration (P<.01), in cases with glycolized hemoglobin (HbA(1c)) 8% (P<.05), and in microangiopathic cases (P<.01), alveolo-capillary permeability was significantly decreased than in the control group. Among the same groups, no significant difference could be detected for DLCO. The permeability of alveolar basement membrane can reduce in respect to diabetes duration and poor metabolic control. According to our investigation, (99m)Tc-DTPA aerosol scintigraphy method is more sensitive than DLCO method for determining these pathologies.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Ozşahin K,Tuğrul A,Mert S,Yüksel M,Tuğrul Gdoi
10.1016/j.jdiacomp.2005.07.003subject
Has Abstractpub_date
2006-07-01 00:00:00pages
205-9issue
4eissn
1056-8727issn
1873-460Xpii
S1056-8727(05)00088-7journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Apolipoprotein A-II (ApoA-II) constitutes approximately 20% of the total HDL protein content. The results of various studies on the relationship between cardiovascular diseases (CVD) and the plasma ApoA-II level are contradictory. The aim of this study was to determine the relationship between ApoA-II polymo...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.05.024
更新日期：2015-09-01 00:00:00
abstract：:Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2017.08.012
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Type 1 diabetes (T1DM) is a pro-inflammatory state characterized by high C-reactive protein (CRP) levels. However, there is a paucity of data examining the role of CRP in promoting the pro-inflammatory state of diabetes. Thus, we examined the pro-inflammatory effects of human CRP using spontaneously diabetic ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2012.03.020
更新日期：2013-01-01 00:00:00
abstract：AIMS:There are few data available on the incremental benefits of risk factor modification in type 2 diabetes mellitus (T2DM). We simulated the potential benefits of achieving lower systolic blood pressure (SBP) and LDL-cholesterol targets. METHODS:We used the UKPDS Outcomes Model v2.0 to estimate 10-year event rates f...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.09.017
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The prevalence of the metabolic syndrome is rapidly increasing with a considerable ethnic variation within and across populations. This study was conducted to estimate the prevalence of the metabolic syndrome and its individual components using Adult Treatment Panel III (ATP III) criteria among Northern Jord...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2005.11.003
更新日期：2007-07-01 00:00:00
abstract：AIMS:This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D). METHODS:12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox pr...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2013.06.005
更新日期：2014-05-01 00:00:00
abstract：:Diabetic retinopathy resists arrest of its progression after reestablishment of good glycemic control that follows a profound period of poor glycemic control. The objective of this study was to elucidate the role of inflammation in the resistance of retinopathy to arrest after termination of hyperglycemia. Streptozoto...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2008.10.002
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:MicroRNAs (miRNAs) have emerged as promising regulators of diabetes mellitus (DM)-induced angiogenic dysfunction in endothelial cells (ECs), but information vis-à-vis the functional roles of distinct miRNAs remain surprisingly scarce. The current study was designed to elucidate the expression and function of ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.02.001
更新日期：2019-05-01 00:00:00
abstract：AIMS:We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. METHODS:Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional ass...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jdiacomp.2017.01.019
更新日期：2017-05-01 00:00:00
abstract：:Vasomotion, the spontaneous rhythmic contraction exhibited by small arteries and arterioles is dysregulated in patients with diabetic neuropathy. We examined the relationship between Charcot arthropathy and vasomotion at the dorsum of the foot. We studied nine diabetic patients with clinically diagnosed neuropathy and...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(97)00080-9
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVES:The objectives of this study were to evaluate and to compare the glycemic control of various antidiabetic agents and the role of homocysteine in type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:Two hundred forty patients with type 2 diabetes mellitus, divided into Groups 1-6 (n=40), received glipizide,...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2006.09.001
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:We investigated the clinical relevance of non-albumin proteinuria (NAP) in Korean patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:We enrolled 883 T2D patients who had both their urinary albumin-to-creatinine ratio (uACR) and protein-to-creatinine ratio (uPCR) measured. We classified the pati...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.04.014
更新日期：2019-08-01 00:00:00
abstract：:This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic gluco...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/1056-8727(95)80005-y
更新日期：1995-10-01 00:00:00
abstract：AIMS:To estimate the cost of diabetes complications in the United States (U.S.). METHODS:We constructed longitudinal panel data using one of the largest claims databases in the U.S. for privately insured Type 1 (T1DM) and type 2 (T2DM) diabetes patients with a follow-up time of one to ten years. Complication costs wer...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2020.107735
更新日期：2020-12-01 00:00:00
abstract：AIMS:Investigate the importance of treating diabetes by evaluating mortality risk of untreated and medically-treated diabetic patients. METHODS:Historical prospectively collected observational data of hospitalized patient ≥18years, admitted for any-cause to medical wards, between January 2011 and December 2013. Main o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.04.011
更新日期：2016-08-01 00:00:00
abstract：:Type 2 diabetes results from the abnormal resistance of peripheral tissues to insulin and from the progressive insulin secretory failure of the pancreatic beta-cells. Treatment of type 2 diabetes has greatly improved due to the availability of new classes of oral antidiabetic drugs (OADs) and new insulin analogs. Thre...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/s1056-8727(01)00207-0
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:Hyperglycemia-induced inflammation is central to the vascular complications in diabetes. Toll-like receptors (TLRs) are key players in regulating inflammatory responses. There are sparse data on the role of TLR2 and TLR4 in regulating human macrovascular aortic endothelial cells (HMAECs) inflammation and gly...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.01.014
更新日期：2016-05-01 00:00:00
abstract：AIMS:To assess the impact of diabetic foot care delivery in preventing lower extremity amputation (LEA). METHODS:We systematically searched the MEDLINE database for research evaluating the association between any aspect of diabetic foot care delivery and risk of LEA. Meta-analysis was conducted by calculating a pooled...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2020.107837
更新日期：2020-12-31 00:00:00
abstract：AIMS:Increased adiposity is a risk factor for suboptimal diabetes control and cardiovascular disease (CVD) complications. Our goal was to identify modifiable behavioral characteristics of overweight and obese pediatric patients with type 1 diabetes mellitus (T1DM) who achieve optimal glycemic control and to evaluate th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.107513
更新日期：2020-04-01 00:00:00
abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is associated with approximately two fold increase in coronary heart disease (CHD) in men and fourfold increase in CHD in women. In most studies, the duration of diabetes and severity of glycemia are only weakly related to CHD in NIDDM, suggesting that the prediabetic pe...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/s1056-8727(96)00099-2
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Unprovoked "A-β+" Ketosis-Prone Diabetes (KPD), a unique diabetic syndrome of adult-onset, obesity and proneness to ketoacidosis, is associated with rapid recovery of β cell function and insulin-independence. Whereas most patients experience prolonged remission, a subset relapses early to insulin dependence. ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.04.013
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:Two insulin regimens were used to explore acute and chronic postprandial changes in glycemia, lipemia, and metabolic markers associated with increased risk of cardiovascular disease. METHODS:An open-label, randomized, two-period crossover study (12 weeks/period) compared a prandial regimen [premeal insulin l...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2005.11.005
更新日期：2007-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the mortality experience of persons with longstanding diabetes who had received pituitary irradiation for diabetic retinopathy compared to a matched group of persons with diabetes who had not had pituitary ablation. The irradiated cohort consisted of 167 patients treated at th...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/s1056-8727(97)00124-4
更新日期：1998-09-01 00:00:00
abstract：AIMS:To evaluate whether increased urinary orosomucoid excretion rate (UOER) is an independent predictor of cardiovascular and all-cause mortality in type 2 diabetes (T2DM) and type 1 diabetes (T1DM) at 10years of follow-up. METHOD:We followed 430 patients with T2DM and 148 patients with T1DM until emigration, death o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2013.05.008
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:In diabetes, foot ulceration may result from increased skin fragility. Retinoids can reverse some diabetes-induced deficits of skin structure and function, but their clinical utility is limited by skin irritation. The effects of diabetes and MDI 301, a nonirritating synthetic retinoid, and retinoic acid have...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2011.10.002
更新日期：2011-11-01 00:00:00
abstract：AIMS:The Japan Diabetes Complications Study (JDCS), a nation-wide, multicenter, prospective study of patients with type 2 diabetes, reported that hemoglobin A1c (HbA1c), systolic blood pressure, and smoking were risk factors for the onset of macroalbuminuria. This study explored the risk factors for glomerular filtrati...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jdiacomp.2016.06.020
更新日期：2017-02-01 00:00:00
abstract：AIMS:To compare the effects of structured and routine testing regimens used in self-monitoring of blood glucose (SMBG) on glycemic control and diabetes self-management in insulin-naïve type 2 diabetes patients. METHODS:Sixty-two outpatients with insulin-naïve type 2 diabetes were randomly allocated into two less-frequ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2016.08.019
更新日期：2017-01-01 00:00:00
abstract：:Painful diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus, affecting, by some estimates, up to one quarter of diabetic patients. Since 2010, no fewer than 5 major international treatment guidelines for painful DPN have been issued, and there are meaningful differences among them. Dulox...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2014.08.008
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To measure trends in glycemic control in type 2 diabetes in the United States from 1988-1994 to 1999-2004 and to identify factors influencing glycemic control, including the presence of comorbid conditions and race/ethnicity. METHODS:Participants in the National Health and Nutrition Examination Surveys (1988...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.07.001
更新日期：2010-11-01 00:00:00
abstract：AIMS:The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS:In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as ad...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.07.012
更新日期：2017-11-01 00:00:00
