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Plasma NT-proBNP is independently associated with albuminuria in type 2 diabetes.

Abstract：

OBJECTIVE:The aim of this study is to investigate the relationship between plasma NH2-terminal pro-brain natriuretic peptide (NT-proBNP) levels and diabetic nephropathy in type 2 diabetic patients. METHODS:The records of 983 patients with type 2 diabetes hospitalized in the Endocrinology and Metabolism Department of Peking University People's Hospital between January 2009 and December 2012 were reviewed. Based on their urinary albumin-to-creatinine ratio (UACR), the subjects were divided into three groups, those with normal, micro- and macro-albuminuria. Clinical manifestations and biochemical parameters, including plasma NT-proBNP concentrations, were compared between the three groups. The association between plasma NT-proBNP levels and stages of diabetic nephropathy was also evaluated by ordinal and stepwise linear regression analyses. RESULTS:The median plasma NT-proBNP concentration in the 983 patients with type 2 diabetes was 60.3 pg/ml, which is within the normal range of healthy subjects. One-way ANOVA analysis showed significant differences in plasma NT-proBNP concentrations among the three groups (p=0.000). Ordinal logistic regression analysis showed that plasma NT-proBNP concentration was an independent risk factor for advanced diabetic nephropathy (odds ratio=1.87,95% CI 1.52-2.29, p=0.000). Plasma NT-proBNP concentration was highly correlated with UACR (r=0.421, p=0.000) and had an independently positive association with UACR by stepwise linear regression analysis (p=0.000). CONCLUSION:Plasma NT-proBNP levels correlated with the degree of diabetic nephropathy in patients with type 2 diabetes.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Zhou L,Cai X,Li M,Han X,Ji L

doi

10.1016/j.jdiacomp.2016.01.017

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

669-74

issue

4

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(16)00019-2

journal_volume

30

pub_type

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