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Synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes: functional analysis by gene ontology.

Abstract：

:Plasma semicarbazide-sensitive amine oxidase (SSAO) and angiotensin-converting enzyme (ACE) were studied for their correlation with diabetes (DM) complication. The effect of interaction between SSAO and ACE in DM complication is of interest. Studying the functional change due to interaction between SSAO and ACE is difficult. In this work, the author used a new gene ontology technology to predict the functional change resulting from the interaction between SSAO and ACE. According to this study, there is a synergetic effect resulting from the interaction between SSAP and ACE. This can imply that co-expression of SSAP-ACE leads to more severe complication of DM. However, the author can also demonstrate that some molecular functions such as proteasome activator activity of SSAO and hydrolase activity, metallopeptidase activity, and zinc ion binding of ACE are suppressed after co-expression. These results provide good information for further study in diabetes medicine. However, further experimental works are required to support this in silico research.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Wiwanitkit V

doi

10.1016/j.jdiacomp.2007.02.007

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

413-9

issue

6

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(07)00027-X

journal_volume

22

pub_type

杂志文章

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