Abstract：
OBJECTIVE:To determine the prevalence of a negative insulinogenic index (change in plasma insulin/change in plasma glucose from 0 to 30 min) from an oral glucose tolerance test according to glucose tolerance category. MATERIALS AND METHODS:Data from the San Antonio Heart Study (n=2494), Japanese American Community Diabetes Study (JACDS; n=594) and Genetics of NIDDM Study (n=1519) were examined. Glucose tolerance was defined by ADA criteria. RESULTS:In the combined cohort, the prevalence of a negative insulinogenic index was significantly higher in diabetes 20/616 (3.2%) compared to normal glucose tolerance 43/2667 (1.6%) (p<0.05). Longitudinally, in the JACDS cohort, the prevalence did not change from baseline (3/594; 0.5%) to 5 (4/505; 0.7%) and 10 years (8/426; 1.9%) (p=0.9) and no subject had a repeat negative insulinogenic index. CONCLUSIONS:A negative insulinogenic index occurs at a low prevalence across glucose tolerance categories although more often in diabetes, but without recurrence over time.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Faulenbach MV,Wright LA,Lorenzo C,Utzschneider KM,Goedecke JH,Fujimoto WY,Boyko EJ,McNeely MJ,Leonetti DL,Haffner SM,Kahn SE,American Diabetes Association GENNID Study Group.doi
10.1016/j.jdiacomp.2012.09.011subject
Has Abstractpub_date
2013-03-01 00:00:00pages
158-61issue
2eissn
1056-8727issn
1873-460Xpii
S1056-8727(12)00279-6journal_volume
27pub_type
杂志文章abstract：OBJECTIVE:Two insulin regimens were used to explore acute and chronic postprandial changes in glycemia, lipemia, and metabolic markers associated with increased risk of cardiovascular disease. METHODS:An open-label, randomized, two-period crossover study (12 weeks/period) compared a prandial regimen [premeal insulin l...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2005.11.005
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the prevalence of diabetes-related comorbidities in Asian Americans to the prevalence in other racial and ethnic groups in the United States using data from the 2001 Behavioral Risk Factor Surveillance System (BRFSS). METHODS:The BRFSS is a population-based telephone surv...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2004.08.003
更新日期：2005-03-01 00:00:00
abstract：INTRODUCTION:Diabetic polyneuropathy aetiology is based on oxidative stress generation due to production of reactive oxygen species. Ubiquinone is reduced to ubiquinol and redistributed into lipoproteins, possibly to protect them from oxidation. AIMS:To evaluate the impact of oral ubiquinone in diabetic polyneuropathy...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2012.04.004
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). AIM:To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glyc...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.10.014
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The prevalence of the metabolic syndrome is rapidly increasing with a considerable ethnic variation within and across populations. This study was conducted to estimate the prevalence of the metabolic syndrome and its individual components using Adult Treatment Panel III (ATP III) criteria among Northern Jord...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2005.11.003
更新日期：2007-07-01 00:00:00
abstract：:We compared the levels of microparticles, platelet activation markers, soluble cell adhesion molecules, soluble selectins, and antioxidized low-density lipoprotein (anti-Ox LDL) antibody between patients with hyperlipidemia and control subjects. Binding of anti-glycoprotein (GP) IIb/IIIa and anti-GPIb monoclonal antib...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(02)00172-1
更新日期：2003-05-01 00:00:00
abstract：:Although slow gastric emptying (gastroparesis) is a well-known complication of chronic hyperglycemia in diabetes mellitus (DM), it recently has become clear that rapid gastric emptying also is a frequent and important diabetic complication. In contrast, acute hyperglycemia causes slow gastric emptying, and acute hypog...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2019.107414
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Apolipoprotein A-II (ApoA-II) constitutes approximately 20% of the total HDL protein content. The results of various studies on the relationship between cardiovascular diseases (CVD) and the plasma ApoA-II level are contradictory. The aim of this study was to determine the relationship between ApoA-II polymo...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.05.024
更新日期：2015-09-01 00:00:00
abstract：AIMS:To investigate the effect of a single nucleotide polymorphism (SNP) in transmembrane protein 182 (TMEM182) on the risk of having central obesity and the related phenotype. METHODS:In total, 2141 subjects with central obesity (n = 827) and normal controls (n = 1314) were included. The most strongly associated SNPs...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2020.107732
更新日期：2020-12-01 00:00:00
abstract：AIMS:To highlight the differences between eight international expert panel diagnostic criteria (either current or outdated but in use) for the diagnosis of gestational diabetes mellitus (GDM) and implications of switching to the International Association of Diabetes in Pregnancy Study Groups (IADPSG) criterion. METHOD...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.03.006
更新日期：2015-05-01 00:00:00
abstract：AIM:The aims of this study are to investigate the relative regulation between miR-126 and VEGF/PI3K/AKT signaling pathway in retinal vascular endothelial cells. METHODS:Rhesus macaque choroid-retinal endothelial cell line (RF/6A) cells were cultured in high glucose to imitate the conditions occurring in DR. First, we ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.12.004
更新日期：2017-04-01 00:00:00
abstract：:Hyperglycaemia increases inflammatory cytokine concentration in the blood. Elevated levels of interleukin-18 (IL-18), a cytokine belonging to the interleukin-1 (IL-1) family, were recently reported in patients with Type 2 diabetes mellitus (DM2) and nephropathy. The aim of the present work was an examination of IL-18 ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2005.02.008
更新日期：2005-11-01 00:00:00
abstract：:Radial pulse spectrum has been shown to correlate with coronary stenosis in patients with type 2 diabetes mellitus (T2DM). In academia, it has not been demonstrated that the radial artery pulse spectrum is an independent risk factor for major adverse cardiovascular events (MACE), including myocardial infarction, strok...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.10.009
更新日期：2019-02-01 00:00:00
abstract：AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,meta分析
doi：10.1016/j.jdiacomp.2014.07.007
更新日期：2014-11-01 00:00:00
abstract：AIM:Analyze clustering of unhealthy lifestyle behavior and its relationship with nonadherence to clinical preventive care services among Spanish diabetic adults. METHODS:Cross-sectional study including 2156 diabetic adults from the 2006 Spanish National Health Survey. Subjects were asked about their uptake of BP measu...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2010.04.002
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of the Semmes-Weinstein monofilament examination (SWME) for diabetic peripheral neuropathy (DPN) screening at an outpatient clinic. METHODS:Eighty-two type 2 diabetic outpatients were questioned about 13 subjective symptoms and tested for deep reflexes. They were examined using ...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/j.jdiacomp.2003.12.006
更新日期：2005-01-01 00:00:00
abstract：:The role cardiac autonomic neuropathy (CAN) plays in diabetes is not well known. The aim of this study was to identify the factors involved in CAN in diabetic patients. One hundred patients, 44 insulin-dependent (IDDM) and 56 non-insulin-dependent (NIDDM), were investigated, using five standard tests. Three of these t...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(97)00005-6
更新日期：1997-05-01 00:00:00
abstract：:The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(94)00045-p
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications. METHODS:We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the e...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2018.08.012
更新日期：2018-11-01 00:00:00
abstract：:The study investigated the prevalence of incipient renal dysfunction in two cohorts with identical duration of type I diabetes but with childhood or adult onset of the disease. The pattern of glomerular (albumin, alb) and tubular (alpha(1)-microglobulin, alpha(1)-m, and N-acetyl-beta-D-glucosaminidase, NAG) urinary pr...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(99)00055-0
更新日期：1999-09-01 00:00:00
abstract：AIM:To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS:Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.03.008
更新日期：2018-06-01 00:00:00
abstract：AIMS:Previous studies have reported beneficial effects of chronic resistance exercise in the prevention and treatment of type 2 diabetes. To clarify potential modulators of acute responses to resistance exercise, we reviewed the literature to determine the effects of a single bout of resistance exercise on cardiometabo...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2020.107610
更新日期：2020-08-01 00:00:00
abstract：AIM:To assess the contribution of β-cell dysfunction and insulin resistance to type 2 diabetes (T2D) in obese and non-obese Chinese people. METHODS:In this cross-sectional study, we recruited 1384 newly diagnosed T2D patients and 1712 healthy controls. Insulin resistance was estimated by homeostasis model assessment o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.03.001
更新日期：2016-07-01 00:00:00
abstract：:Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. The increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the MI depletion found in the diabetic complications. The aim was to investigate whether single n...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2009.09.005
更新日期：2010-11-01 00:00:00
abstract：:We examined the potential of astemizole, a histamine H1-receptor antagonist that does not cross the blood-brain barrier, to reverse blood-retinal barrier leakage to albumin in streptozotocin diabetic rats. Four groups of nondiabetic and four groups of diabetic rats received vehicle or astemizole at dosages of 5, 10, o...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(92)90057-r
更新日期：1992-10-01 00:00:00
abstract：:Endothelin (ET)-1 has been implicated in the pathogenesis of diabetes, arteriosclerosis, and chronic renal failure. We studied whether low-density lipoprotein (LDL) apheresis alters plasma ET-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans (ASO). Plasma ET-1 levels were measured in 30 healt...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/s1056-8727(02)00171-x
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference. RESEARCH DESIGN AND METHODS:This was a double-blind, randomized, crossover trial with 20 patients with diabetes me...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdiacomp.2009.03.002
更新日期：2010-03-01 00:00:00
abstract：:This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic gluco...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章
doi：10.1016/1056-8727(95)80005-y
更新日期：1995-10-01 00:00:00
abstract：AIMS:The GLP-1 receptor agonist liraglutide improves impaired pancreatic β-cell function, thereby exerting glucose-lowering effects. However, the association of remaining β-cell function with long-term therapeutic efficacy of liraglutide remains largely unknown. METHODS:Patients with type 2 diabetes who started liragl...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.07.020
更新日期：2015-11-01 00:00:00
abstract：:Intact lenses from New Zealand white rabbits were incubated in tissue culture media containing either 5 mM glucose or 5 mM glucose plus 30 mM galactose. The standard media did not contain taurine. Lenses were also cultured in a third medium containing 30 mM galactose plus 0.2 mM taurine. The frequency of cataract form...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(93)90023-r
更新日期：1993-01-01 00:00:00
