Increasing the miR-126 expression in the peripheral blood of patients with diabetic foot ulcers treated with maggot debridement therapy.

Abstract:

BACKGROUND:miR-126 may increase angiogenesis in patients with diabetic foot ulcers (DFUs) treated with maggot debridement therapy (MDT). METHODS:Real-time quantitative PCR was used to detect expression of miR-126 mRNA in the peripheral blood among the non-diabetic population, type 2 diabetes mellitus patients without DFU, and patients with DFUs of type 2 diabetes mellitus. The expression of miR-126 mRNA in the peripheral blood of patients with DFUs was observed before and after MDT. Finally, human umbilical vein endothelial cells (HUVEC) were utilized to explore miR-126 mRNA expression with maggot excretions/secretions (ES). RESULTS:In the patients with DFUs, the miR-126 mRNA expression level in the peripheral blood was less than that type 2 diabetes mellitus patients without DFU, and much lower than that in the non-diabetic population (P<0.001). The miR-126 expression level was significantly increased in those DFU patients treated with MDT (P<0.05). Finally, using HUVEC co-cultured with ES, we showed the ES increased miR-126 expression in vitro (P<0.001). CONCLUSION:MDT upregulates the miR-126 expression in the peripheral blood of patients with DFUs.

authors

Zhang J,Sun XJ,Chen J,Hu ZW,Wang L,Gu DM,Wang AP

doi

10.1016/j.jdiacomp.2016.07.026

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

241-244

issue

1

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(16)30328-2

journal_volume

31

pub_type

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