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High-intensity statin therapy and regression of coronary atherosclerosis in patients with diabetes mellitus.

Abstract：

:Recommended low-density lipoprotein cholesterol (LDL-C) levels for patients with documented cardiovascular disease (CVD) are <100mg/dL (2.6mmol/l) with further reduction to <70mg/dL (1.8mmol/l) for higher-risk patients. High-intensity statin treatment may halt the progression as well as stabilize and induce regression of coronary atheromatous plaques while lowering CVD event rates. Diabetes mellitus (DM) is a major negative determinant of coronary artery plaque regression during statin therapy. However, regression of coronary atherosclerosis in DM patients is feasible to the same degree as in those without DM when very low LDL-C values (<70mg/dL; 1.8mmol/l) are achieved with high intensity statin treatment. The recent 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults suggest to abandon specific LDL-C treatment targets. This strategy may deprive high risk patients, such as those with DM, from very high intensity statin treatment or drug combinations aiming to achieve very low LDL-C levels in order to reduce clinical events.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Athyros VG,Katsiki N,Karagiannis A,Mikhailidis DP

doi

10.1016/j.jdiacomp.2014.10.004

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

142-5

issue

1

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(14)00297-9

journal_volume

29

pub_type

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