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Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis.

Abstract：

:A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious anaemia and gastric carcinoids in DMT1 patients. Screening for AGPA followed by serum gastrin and vitamin B(12) levels constitute the most evidence-based diagnostic approach.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Tzellos TG,Tahmatzidis DK,Lallas A,Apostolidou K,Goulis DG

doi

10.1016/j.jdiacomp.2008.05.003

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

434-7

issue

6

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(08)00052-4

journal_volume

23

pub_type

杂志文章

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