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PAX4 R192H is associated with younger onset of Type 2 diabetes in East Asians in Singapore.

Abstract：

AIMS:Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly, in our preliminary YT2D (mean = 25 years old) cohort, the prevalence of PAX4 R192H variant was remarkably higher (21.4%) than the general population. Therefore, we sought to determine whether PAX4 R192H is associated with younger onset of T2D in our East Asian (Chinese) population. METHODS:Genotyping of PAX4 R192H was carried out using Illumina OmniExpress BeadChips as part of a genome-wide association study. Data analysis was performed using SPSS Ver. 22. RESULTS:PAX4 R192H genotype was associated with younger onset age (CC: 47.1, CT: 46.0, TT: 42.6) after adjusting for gender, F = 5.402, p = 0.005. Independently, onset of diabetes was younger among males by 2.52 years, 95% CI [-3.45, -1.59], p < 0.0001. HOMA-IR and HOMA-%B were not significantly different across genotypes for a subset (n = 1045) of the cohort. CONCLUSIONS:Minor allele (T) of PAX4 R192H is associated with younger onset diabetes among Chinese in Singapore. Determining this genotype is important for identifying at-risk individuals for earlier onset diabetes and diabetic complications.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Ang SF,Tan CSH,Wang L,Dorajoo R,Fong JCW,Kon WYC,Lian JX,Ang K,Rahim JB,Jeevith B,Lee SBM,Tang WE,Subramanium T,Sum CF,Liu JJ,Lim SC

doi

10.1016/j.jdiacomp.2018.10.002

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

53-58

issue

1

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(18)30227-7

journal_volume

33

pub_type

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