Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus.

Abstract:

AIM:To identify the prevalence and effect of hepatopathies of different etiologies among pediatric patients with type 1 diabetes mellitus (T1DM) using transient elastography (TE) and its relation to glycemic control. METHODS:One hundred T1DM patients were studied focusing on liver functions, fasting lipid profile, hemoglobin A1c (HbA1c), hepatitis C virus (HCV), serum immunoglobulins, autoimmune antibodies; anti-nuclear antibody (ANA), anti-smooth muscle antibody (ASMA), and anti-liver kidney microsomal antibody (anti-LKM). Abdominal ultrasound was performed and TE was done for patients with HCV, positive autoimmune antibody and/or abnormal ultrasound findings. RESULTS:Thirty-one patients were found to have one or more hepatic abnormalities; clinical hepatomegaly in 8%, elevated alanine aminotransferase (ALT) in 10%, HCV in 6%, autoimmune hepatitis (AIH) in 11% (10 were positive for ASMA and 2 were positive for ANA while anti-LKM antibodies were negative) and abnormal hepatic ultrasound in 20% (12 non-alcoholic fatty liver disease, 5 AIH, 2 HCV, 1 Mauriac syndrome). Mean liver stiffness in those 31 patients was 7.0±2.1kPa (range, 3.1-11.8kPa); 24 were Metavir F0-F1, 7 were F2-F3 while none was F4. Type 1 diabetic patients with abnormal hepatic ultrasound had higher fasting blood glucose, HbA1c and total cholesterol than those with normal findings. Liver stiffness was significantly higher in patients with abnormal liver ultrasound compared with normal sonography. Liver stiffness was positively correlated to HbA1c and ALT. CONCLUSIONS:Hepatic abnormalities are prevalent in T1DM and related to poor metabolic control. TE provides a non-invasive method for detection of hepatopathy-induced fibrosis.

authors

Elkabbany ZA,Elbarbary NS,Ismail EA,Mohamed NA,Ragab D,Abdel Alem S,Ezzat YM,Maurice SS,Hashem NU

doi

10.1016/j.jdiacomp.2016.09.009

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

186-194

issue

1

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(16)30422-6

journal_volume

31

pub_type

杂志文章
  • Diabetic peripheral neuropathy: effects of age, duration of diabetes, glycemic control, and vascular factors.

    abstract::The aim of this study was to determine the factors associated with diabetic peripheral neuropathy and more particularly its relation to precisely assessed microangiopathy. Peripheral neuropathy was assessed in 135 diabetic patients: 28 insulin-dependent diabetes mellitus (IDDM), 85 non-insulin-dependent diabetes melli...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(95)00086-0

    authors: Valensi P,Giroux C,Seeboth-Ghalayini B,Attali JR

    更新日期:1997-01-01 00:00:00

  • Factors associated with psychological distress, behavioral impact and health-related quality of life among patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Data on psychological distress (DIS), behavioral impact (BI) and health-related quality of life (HRQoL) are important yet lacking among Asian patients with Type 2 diabetes mellitus (T2DM). We aim to identify factors associated with DIS, BI and HRQoL among T2DM to better understand patient needs. METHODS:DIS...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2015.01.009

    authors: Co MA,Tan LS,Tai ES,Griva K,Amir M,Chong KJ,Lee YS,Lee J,Khoo EY,Wee HL

    更新日期:2015-04-01 00:00:00

  • Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes.

    abstract:BACKGROUND:Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2016.10.003

    authors: Scalzo RL,Moreau KL,Ozemek C,Herlache L,McMillin S,Gilligan S,Huebschmann AG,Bauer TA,Dorosz J,Reusch JE,Regensteiner JG

    更新日期:2017-02-01 00:00:00

  • Carnitine deficiency in children and adolescents with type 1 diabetes.

    abstract::Carnitine is essential for the lipid and carbohydrate metabolism, and proper metabolic control in type 1 diabetes has potential impact on long-term complications. The plasma total, free, and acylcarnitine levels in 47 children and adolescents with type 1 diabetes were determined by a radioisotopic assay and compared t...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/S1056-8727(03)00091-6

    authors: Mamoulakis D,Galanakis E,Dionyssopoulou E,Evangeliou A,Sbyrakis S

    更新日期:2004-09-01 00:00:00

  • Retinal vessel reactivity is not attenuated in patients with type 2 diabetes compared with matched controls and is associated with peripheral endothelial function in controls.

    abstract:BACKGROUND AND AIMS:Attenuated retinal vasoreactivity in patients with type 2 diabetes preceding diabetic retinopathy development has been proposed to reflect local endothelial dysfunction. Whether retinal vessel reactivity is associated with peripheral endothelial dysfunction and large artery stiffness in patients wit...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.05.024

    authors: Baier JM,Funck KL,Petersen L,Vernstrøm L,Knudsen ST,Bek T,Poulsen PL,Laugesen E

    更新日期:2019-09-01 00:00:00

  • Effects of a calcium channel blocker, manidipine, on insulin sensitivity in essential hypertensives.

    abstract::This study was designed to investigate the effects of the calcium channel blocker manidipine on insulin-dependent glucose uptake (insulin sensitivity) and insulin action to renal sodium handling and pressor systems in essential hypertensive (EHT). Seven EHT were hospitalized and a 2-h euglycemic hyperinsulinemic gluco...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章

    doi:10.1016/1056-8727(95)80005-y

    authors: Iimura O,Shimamoto K,Masuda A,Higashiura K,Miyazaki Y,Hirata A,Fukuoka M,Murakami H

    更新日期:1995-10-01 00:00:00

  • STZ treatment induced apoptosis of retinal cells and effect of up-regulation of calcitonin gene related peptide in rats.

    abstract:BACKGROUND:Evidence indicates an early neural injury of the retinal cells in diabetes. The aim of the current study was to investigate the apoptosis of the retinal cells and the relationship with CGRP. MATERIALS AND METHODS:The diabetes was induced by treatment of STZ, using which the apoptosis of retinal cells, the c...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.08.001

    authors: Yang JH,Guo Z,Zhang T,Meng XX,Sun T,Wu J

    更新日期:2013-11-01 00:00:00

  • Psychological and quality of life changes in patients using GLP-1 analogues.

    abstract:AIMS:Using psychological and quality of life assessment tools, we prospectively studied changes in health-related quality of life and emotional well-being in patients who had commenced GLP-1 analogue therapy (exenatide) and compared them with new insulin starters. METHODS:Two matched groups of patients with type 2 dia...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2011.03.002

    authors: Grant P,Lipscomb D,Quin J

    更新日期:2011-07-01 00:00:00

  • Clustering of unhealthy lifestyle behaviors is associated with nonadherence to clinical preventive recommendations among adults with diabetes.

    abstract:AIM:Analyze clustering of unhealthy lifestyle behavior and its relationship with nonadherence to clinical preventive care services among Spanish diabetic adults. METHODS:Cross-sectional study including 2156 diabetic adults from the 2006 Spanish National Health Survey. Subjects were asked about their uptake of BP measu...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2010.04.002

    authors: Jiménez-García R,Esteban-Hernández J,Hernández-Barrera V,Jimenez-Trujillo I,López-de-Andrés A,Carrasco Garrido P

    更新日期:2011-03-01 00:00:00

  • Long-term effects of antihypertensive treatment and good glycemic control on plasma lipids in diabetic rats.

    abstract::The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(94)00045-p

    authors: Reddi AS,Jyothirmayi GN,Bollineni JS

    更新日期:1995-07-01 00:00:00

  • Lixisenatide plus basal insulin in patients with type 2 diabetes mellitus: a meta-analysis.

    abstract:AIMS:The efficacy of the once-daily prandial GLP-1 receptor agonist lixisenatide plus basal insulin in T2DM was assessed by pooling results of phase III trials. METHODS:A meta-analysis was performed of results from three trials in the GetGoal clinical program concerning lixisenatide or placebo plus basal insulin with/...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jdiacomp.2014.07.007

    authors: Charbonnel B,Bertolini M,Tinahones FJ,Domingo MP,Davies M

    更新日期:2014-11-01 00:00:00

  • Diabetic phenotype of transgenic pigs introduced by dominant-negative mutant hepatocyte nuclear factor 1α.

    abstract:AIM:The present study aimed to identify the characteristics of genetically modified pigs carrying a mutant human gene as a research model for diabetes and its complications. METHODS:We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e., human HNF-1α (P291fsinsC), which is responsible for ma...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.01.025

    authors: Umeyama K,Nakajima M,Yokoo T,Nagaya M,Nagashima H

    更新日期:2017-05-01 00:00:00

  • Prognostic indices for intra-hospital mortality in Nigerian diabetic NIDDM patients. Role of gender and hypertension.

    abstract::Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(00)00069-6

    authors: Kolawole BA,Ajayi AA

    更新日期:2000-03-01 00:00:00

  • Prevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitus.

    abstract:AIMS:To estimate the prevalence of symptoms suggestive of gastroparesis and their association to clinical and demographic data in a large population of patients with diabetes mellitus and in the general population in Israel. METHODS:A cross-sectional survey of type 2 diabetic patients treated in community settings was...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.02.004

    authors: Dickman R,Kislov J,Boaz M,Ron Y,Beniashvili Z,Raz I,Baigel I,Niv Y,Wainstein J

    更新日期:2013-07-01 00:00:00

  • Prostaglandins and diabetic nephropathy.

    abstract::Abnormalities of renal prostaglandins (PGs) contribute to the pathogenesis of diabetic nephropathy through changes in renal hemodynamics. Our recent studies have demonstrated that urinary excretion ratio of 6-keto-PGF1 alpha (6KF) to TXB2 is decreased in patients with non-insulin-dependent diabetes mellitus (NIDDM). I...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(95)80035-d

    authors: Umeda F,Kuroki T,Nawata H

    更新日期:1995-10-01 00:00:00

  • Differentially methylated circulating DNA: A novel biomarker to monitor beta cell death.

    abstract::Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2017.08.012

    authors: Liu Y,Tan Q,Liu F

    更新日期:2018-03-01 00:00:00

  • Screening for impaired fasting glucose and diabetes using available health plan data.

    abstract:AIMS:To develop and validate prediction equations to identify individuals at high risk for type 2 diabetes using existing health plan data. METHODS:Health plan data from 2005 to 2009 from 18,527 members of a Midwestern HMO without diabetes, 6% of whom had fasting plasma glucose (FPG) ≥110mg/dL, and health plan data fr...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.01.003

    authors: McEwen LN,Adams SR,Schmittdiel JA,Ferrara A,Selby JV,Herman WH

    更新日期:2013-11-01 00:00:00

  • The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy.

    abstract::In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(95)80025-a

    authors: Utsunomiya K,Ohta H,Kurata H,Tajima N,Isogai Y

    更新日期:1995-10-01 00:00:00

  • Mexican population sub-analysis of the lixilan clinical program with the fixed ratio combination of insulin glargine and lixisenatide (iGlarLixi).

    abstract:AIM:To evaluate the efficacy and safety of iGlarLixi in Mexican patients with type 2 diabetes who participated in the LixiLan clinical trials and compare results with the rest of the patients. METHODS:Data was collected for Mexican patients who participated in either of three studies: phase 2 trial LixiLan-POC, that c...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.05.020

    authors: González-Gálvez G,Díaz-Toscano ML,Llamas-Moreno JF,Fernández-Rodarte K,Sañudo-Maury ME

    更新日期:2020-08-01 00:00:00

  • Association between ApoA-II -265T/C polymorphism and oxidative stress in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Apolipoprotein A-II (ApoA-II) constitutes approximately 20% of the total HDL protein content. The results of various studies on the relationship between cardiovascular diseases (CVD) and the plasma ApoA-II level are contradictory. The aim of this study was to determine the relationship between ApoA-II polymo...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2015.05.024

    authors: Koohdani F,Sadrzadeh-Yeganeh H,Djalali M,Eshraghian M,Keramat L,Mansournia MA,Zamani E

    更新日期:2015-09-01 00:00:00

  • Depression and incident lower limb amputations in veterans with diabetes.

    abstract:PROBLEM:Depression is associated with a higher risk of macrovascular and microvascular complications and mortality in diabetes, but whether depression is linked to an increased risk of incident amputations is unknown. We examined the association between diagnosed depression and incident non-traumatic lower limb amputat...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2010.07.002

    authors: Williams LH,Miller DR,Fincke G,Lafrance JP,Etzioni R,Maynard C,Raugi GJ,Reiber GE

    更新日期:2011-05-01 00:00:00

  • Paecilomyces varioti pneumonia in a patient with diabetes mellitus.

    abstract::Paecilomyces is a saprophytic soil fungus that is an uncommon human pathogen. We report a diabetic patient who developed an upper lobe pulmonary infection due to Paecilomyces varioti. This pneumonia responded poorly to oral imidazole therapy with ketoconazole. Eventual treatment of the chronic infiltrating process req...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(92)90027-i

    authors: Byrd RP Jr,Roy TM,Fields CL,Lynch JA

    更新日期:1992-04-01 00:00:00

  • Self-rated health among American adolescents with type 1 diabetes in the T1D Exchange Clinic Registry.

    abstract:BACKGROUND:The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D). METHODS:A logistic regression analysis of baseline data from adolescents in the United States included in the T1D Exchange Clinic Registry in 2010-2012 was conducted. Participants were 13-18years old...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.09.013

    authors: Abualula NA,Rodan MF,Milligan RA,Jacobsen KH

    更新日期:2018-01-01 00:00:00

  • Diabetes mellitus and malignant external otitis: a case study.

    abstract::Malignant external otitis (MEO) is an infection of the external auditory meatus, that affects elderly diabetic patients. As this disease results in a high percentage of deaths, especially if the diagnosis is delayed, we thought that it would be useful to cite a recent case study that was resolved in a positive way, in...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(94)00043-3

    authors: Manfrini S,Gregorio F,Capoolicasa E

    更新日期:1996-01-01 00:00:00

  • Effect of low-density lipoprotein apheresis on plasma endothelin-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans.

    abstract::Endothelin (ET)-1 has been implicated in the pathogenesis of diabetes, arteriosclerosis, and chronic renal failure. We studied whether low-density lipoprotein (LDL) apheresis alters plasma ET-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans (ASO). Plasma ET-1 levels were measured in 30 healt...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章

    doi:10.1016/s1056-8727(02)00171-x

    authors: Nakamura T,Ushiyama C,Osada S,Inoue T,Shimada N,Koide H

    更新日期:2003-11-01 00:00:00

  • Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.

    abstract::Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship betw...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.05.023

    authors: Wiromrat P,Bjornstad P,Roncal C,Pyle L,Johnson RJ,Cherney DZ,Lipina T,Bishop F,Maahs DM,Wadwa RP

    更新日期:2019-09-01 00:00:00

  • Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats.

    abstract:AIM:Changes in glycoconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as fiber-rich source. METHOD:This was studied by measuring the contents of total sugar, uronic acid, amino sugar, and sulfate in the streptozotocin-induced diabetic ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2007.09.005

    authors: Vijayalakshmi B,Kumar GS,Salimath PV

    更新日期:2009-01-01 00:00:00

  • Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes.

    abstract:AIM:To evaluate the risk of urinary tract infections (UTI) in subjects with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Subjects aged ≥18years and diagnosed with T2DM between 1/1/10 and 12/31/10 were identified using the MarketScan® databases, which are representative of the commercially insured US popula...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2014.06.009

    authors: Fu AZ,Iglay K,Qiu Y,Engel S,Shankar R,Brodovicz K

    更新日期:2014-11-01 00:00:00

  • Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: a two-year observational study.

    abstract:AIMS:To observe the natural history of hand function during a two-year period in participants with hand syndromes associated with diabetes and to determine factors related to changing function. METHODS:Hand function was measured over three annual visits using Disability of the Arm, Shoulder and Hand (DASH) and SF-36v2...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2012.04.009

    authors: Redmond CL,Bain GI,Laslett LL,McNeil JD

    更新日期:2012-07-01 00:00:00

  • Silent atrial fibrillation detected by home-monitoring: Cardiovascular disease and stroke prevention in patients with diabetes.

    abstract:OBJECTIVE:Patients with silent and undiagnosed paroxysmal atrial fibrillation and flutter (AF) have increased risk of ischemic stroke. Patients with diabetes have a higher risk of both AF and ischemic stroke compared to patients without diabetes. Our aim was to investigate the prevalence of silent AF in patients with d...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2020.107711

    authors: Højager A,Tingsgaard JK,Andersen D,Søholm H,Taskiran M,Bock TG,Schoos MM

    更新日期:2020-12-01 00:00:00