Abstract:
:Monocyte chemoattractant protein-1 (MCP-1), is a chemokine that mediates renal interstitial inflammation, tubular atrophy, and interstitial fibrosis by recruiting monocytes/macrophages into renal tubulointerstitium. Recent studies have demonstrated that protein overload in renal tubular cells up-regulates MCP-1 gene and its protein expression. Therefore, we hypothesized that increased expression of MCP-1 in renal tubuli, probably triggered by an increase in the leakage of plasma protein from glomerular capillary to tubular fluid, may contribute to renal tubular damage and accelerate the progression of diabetic nephropathy. To test this hypothesis, we examined urinary excretion levels of MCP-1 and N-acetylglucosaminidase (NAG), a sensitive marker of renal tubular damage, in Japanese Type II diabetic patients with normoalbuminuria (n=29), microalbuminuria (n=25), and macroalbuminuria (n=18). The median urinary excretion level of MCP-1 in patients with macroalbuminuria (394.4 ng/g creatinine) was significantly elevated compared to the levels in patients with normoalbuminuria and microalbuminuria (159.6 and 193.9 ng/g creatinine, respectively). Furthermore, the urinary MCP-1 excretion level was positively correlated with urinary excretion levels of albumin (r=.816, P<.001) and NAG (r=.569, P<.001) in all subjects. These results suggest that MCP-1 is produced in renal tubular cells and released into urine in proportion to the degree of proteinuria (albuminuria), and that increased MCP-1 expression in renal tubuli contributes to renal tubular damage. Therefore, we conclude that heavy proteinuria itself may accelerate the progression of diabetic nephropathy by increasing the MCP-1 expression in renal tubuli.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Morii T,Fujita H,Narita T,Shimotomai T,Fujishima H,Yoshioka N,Imai H,Kakei M,Ito Sdoi
10.1016/s1056-8727(02)00176-9keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
11-5issue
1eissn
1056-8727issn
1873-460Xpii
S1056872702001769journal_volume
17pub_type
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes and its complications
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更新日期:2014-11-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/1056-8727(95)80005-y
更新日期:1995-10-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(96)00048-7
更新日期:1997-07-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2005.03.003
更新日期:2005-09-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.12.007
更新日期:2013-07-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(95)00086-0
更新日期:1997-01-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.12.027
更新日期:2016-04-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2013.09.004
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2006.02.006
更新日期:2007-05-01 00:00:00
abstract:AIMS:Determine the prevalence of glucocorticoid use in U.S. adults with diabetes and whether prevalence is associated with reduced skeletal health, as measured by fracture history and bisphosphonate use. METHODS:Participants were age≥20years from the cross-sectional National Health and Nutrition Examination Survey (19...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.06.021
更新日期:2017-02-01 00:00:00
abstract:AIMS:Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly,...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00