Abstract：
:Distal symmetric peripheral polyneuropathy (DSPN) is a highly prevalent complication of diabetes. However, underlying pathophysiological mechanisms are multiple and not well understood. The aim of our study was to analyze the oxidative stress levels in circulating mononuclear cells by measuring the glutathione system, malondialdehyde and oxidized-LDL, in 60 type 2 diabetic patients from a well-characterized cohort of 196 type 2 diabetic patients. Using a nested case-control design, we studied 30 type 2 diabetic patients with distal symmetric polyneuropathy and 30 diabetic controls without this complication, according to the Neuropathy Disability Score. We have found that diabetic patients with distal symmetric polyneuropathy showed significantly lower values of reduced glutathione (GSH) and reduced glutathione/oxidized glutathione (GSH/GSSG) ratio. These data indicate an increased consumption of glutathione in mononuclear cells from patients with distal symmetric polyneuropathy. No significant differences were found in malondialdehyde or in oxidized-LDL levels comparing both groups. These data show an altered glutathione response in circulating monocytes from diabetic patients with distal symmetric polyneuropathy.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Mendez MM,Folgado J,Tormo C,Artero A,Ascaso M,Martinez-Hervás S,Chaves FJ,Ascaso JF,Real JTdoi
10.1016/j.jdiacomp.2015.05.023subject
Has Abstractpub_date
2015-09-01 00:00:00pages
923-7issue
7eissn
1056-8727issn
1873-460Xpii
S1056-8727(15)00228-7journal_volume
29pub_type
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