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Plerixafor stimulates adhesive activity and endothelial regeneration of endothelial progenitor cells via elevating CXCR7 expression.

Abstract：

AIMS:To assess the effects of plerixafor on function and endothelial regeneration of endothelial progenitor cells (EPCs). METHODS:The proliferation and adhesion capacity of EPCs were evaluated in vitro. Furthermore, the expression levels of CXC chemokine receptor-7 (CXCR7) were detected before and after treatment with plerixafor. The CXCR7 expression of EPCs was knocked-down by RNA interference to evaluate the role of CXCR7 in regulating function of EPCs. A rat carotid artery injury model was established to assess the influences of plerixafor on endothelial regeneration. RESULTS:Plerixafor stimulated adhesion capacity of EPCs, associating with upregulation of CXCR7 and activation of LFA-1 and VLA-4 molecules. Knockdown of CXCR7 slightly impaired proliferation capacity but significantly attenuated adhesion capacity of EPCs. Plerixafor facilitated endothelial repair at 7 days, while reduced neointimal hyperplasia at 7 and 14 days via recruiting more EPCs participating in endothelial reparation. CONCLUSIONS:Plerixafor can positively regulate adhesion capacity of EPCs to HUVECs via elevating the expression level of CXCR7 and stimulating LFA-1 and VLA-4 molecules activation. Treatment with plerixafor accelerated re-endothelialization and inhibited neointimal hyperplasia after endoth elial injury, indicating that it can to be used for endothelial regeneration.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Jiang C,Li R,Ma X,Hu H,Wei L,Zhao J

doi

10.1016/j.jdiacomp.2020.107654

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

107654

issue

10

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(20)30413-X

journal_volume

34

pub_type

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