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Modeling of hematologic malignancies by iPS technology.

Abstract：

:Induced pluripotent stem cells (iPSCs) can be generated from various types of cells with transduction of defined transcription factors. Patient-derived iPSCs are becoming commonly utilized for understanding the molecular pathways involved in disease and for the development of novel targeted therapies. With the use of patient-derived iPSCs differentiated to specific-lineage cells, the potency and toxicity of drug candidates can be evaluated. In the past, patient-derived iPSCs were mainly established from patients of inherited hematologic diseases, followed by the expansion of target to acquired diseases like myeloproliferative neoplasms. Thanks to the rapid development of novel genome editing technologies, we can now utilize genetically modified and unprocessed iPSCs more readily than before. These technologies, which enable us to modulate genetic status or even chromosome structure at the right time, could help the elucidation of pathogenesis of hematologic diseases. If iPSC-derived hematopoietic cells are to be robustly reconstituted in vivo as a consequence of the development of reprogramming and conversion technology, research on leukemic stem cells must be widely promoted. Therefore, iPSC technology has great potential on oncology research using patient samples.

journal_name

Exp Hematol

journal_title

Experimental hematology

authors

Arai S,Miyauchi M,Kurokawa M

doi

10.1016/j.exphem.2015.06.006

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

654-60

issue

8

eissn

0301-472X

issn

1873-2399

pii

S0301-472X(15)00214-3

journal_volume

43

pub_type

杂志文章,评审

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