Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) on acute radiation hematopoietic injury in mice.

abstract：:Agar cultures of human bone marrow cells stimulated by cord plasma or irradiated cord blood feeder layers demonstrated the presence of a multilineage hemopoietic growth factor in cord blood. When bone marrow cultures stimulated with giant cell tumor-conditioned medium (GCT-CM) were supplemented with this cord blood-de...

journal_title：Experimental hematology

authors： Yuen E,Brown RD,Kronenberg H,Rickard KA

更新日期：1986-09-01 00:00:00

abstract：:A modified regimen of high-dose cyclophosphamide (CTX) plus cyclosporine (CsA) was adopted for patients with severe or very severe aplastic anemia, and the effectiveness was compared with a regimen of antithymocyte globulin (ATG) plus CsA. A total of 121 patients enrolled in this study received either CTX plus CsA (CT...

journal_title：Experimental hematology

authors： Zhang F,Zhang L,Jing L,Zhou K,Wang H,Peng G,Li Y,Li Y,Li J,Ye L,Shi L,Fan H,Zhao X,Chu Y,Hao Y,Wang J

更新日期：2013-04-01 00:00:00

abstract：:An increasing amount of data provides strong evidence for the complex multifactorial control of primary hemopoietic functions. Here we present a new multicellular functional unit, the Hematon, isolated from the light-density floating fraction of normal human bone marrow (BM) aspirates. The Hematon is organized in a co...

journal_title：Experimental hematology

authors： Blazsek I,Misset JL,Benavides M,Comisso M,Ribaud P,Mathé G

更新日期：1990-05-01 00:00:00

abstract：:In this report, the effects of adenosine on the promyelocytic cell line HL-60 and on T-lymphocytic clones are compared. According to previous reports, adenosine induces a dose-dependent inhibition of DNA synthesis in T-lymphocytes. Conversely, adenosine dose-dependently enhances DNA synthesis in HL-60 cells, as docume...

journal_title：Experimental hematology

authors： Orrico A,Capecchi PL,De Magistris T,Nuti S,Pasini FL

更新日期：1991-11-01 00:00:00

abstract：:Ouabain has been shown to increase the number of clonally derived erythroid stem cells, CFUE and BFUE, from normal murine bone marrow. We report here that digoxin and theophylline also enhance erythroid stem cell colony formation, in the presence of suboptimal concentrations of erythropoietin (Ep) (0.01 IU/ml) in meth...

journal_title：Experimental hematology

authors： Gallicchio VS,Chen MG,Murphy MJ Jr

更新日期：1982-09-01 00:00:00

abstract：:Telomeres cap chromosomal ends and are shortened throughout a lifetime. Additional telomere erosion has been documented during conventional chemotherapy or hematopoietic stem cell transplantation. Previous studies of stem cell transplantation reported variable amounts of telomere shortening with inconsistent results r...

journal_title：Experimental hematology

authors： Widmann T,Kneer H,König J,Herrmann M,Pfreundschuh M

更新日期：2008-01-01 00:00:00

abstract：:We compared the effects of recombinant (r) tumor necrosis factor (TNF) and lymphotoxin (rLT) on in vitro colony formation by erythroid, multipotential and granulocyte, monocyte (CFU-GM) precursor cells. Recombinant granulocyte, macrophage-colony stimulating factor and bone marrow preparations enriched for hematopoieti...

journal_title：Experimental hematology

authors： Murphy M,Perussia B,Trinchieri G

更新日期：1988-02-01 00:00:00

abstract：:When cultured mast cells of (WB X C57BL/6)F1-+/+(WBB6F1-+/+) and WB-+/+(WB) mice were directly injected into the skin of genetically mast cell-deficient WBB6F1-W/Wv mice, mast cell clusters appeared at the injection sites. Although in vitro colony-forming ability is comparable between cultured mast cells of WB mice an...

journal_title：Experimental hematology

authors： Nakano T,Waki N,Kanakura Y,Fujita J,Sonoda S,Asai H,Kitamura Y

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:About one third of patients requiring allogeneic hematopoetic stem cell transplantation (HSCT) would not find a matched sibling or alternative donor. Allogeneic HSCT from matched unrelated and mismatched donors carries an increased risk of graft-vs-host disease (GVHD) and transplant-related mortality (TRM). ...

journal_title：Experimental hematology

authors： Ayuk F,Diyachenko G,Zabelina T,Panse J,Wolschke C,Eiermann T,Binder T,Fehse B,Erttmann R,Kabisch H,Bacher U,Kröger N,Zander AR

更新日期：2008-08-01 00:00:00

abstract：:We have previously shown that CD33- CD34+ human marrow cells are capable of giving rise to colony-forming cells (CFC) in long-term marrow culture (LTMC) but are mainly depleted of progenitors that directly form colonies in semi-solid media. In contrast, the CD33+ CD34+ population contains most of the CFC but not the p...

journal_title：Experimental hematology

authors： Bernstein ID,Leary AG,Andrews RG,Ogawa M

更新日期：1991-08-01 00:00:00

abstract：:Transcription factors are essential to govern differentiation along the lymphoid lineage from uncommitted hematopoietic stem cells. Although many of these transcription factors have putative roles based on murine knockout experiments, their function in human lymphoid development is less known and was studied further. ...

journal_title：Experimental hematology

authors： Toor AA,Lund TC,Miller JS

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To examine the possibility of adoptive cellular immunotherapy such as donor lymphocyte infusion using ex vivo expanded cord blood (CBL) lymphocytes, the potential expansion ability of CBL lymphocytes and the function of expanded CBL lymphocytes were evaluated. MATERIALS AND METHODS:Mononuclear cell fractions...

journal_title：Experimental hematology

authors： Azuma H,Yamada Y,Shibuya-Fujiwara N,Yamaguchi M,Murahashi H,Fujihara M,Sato N,Fukazawa K,Ikebuchi K,Ikeda H

更新日期：2002-04-01 00:00:00

abstract：:Recently we have described a CD4+ human T-cell hybridoma Ft.F3 (ATCC HB 9713). This hybridoma produces two proteins having molecular weights of 29 kd (P29) and 14.7 kd (P14.7) that function as activators of human monocyte tumor cytotoxicity and interleukin 1 (IL-1) synthesis (macrophage cytotoxicity-inducing factors, ...

journal_title：Experimental hematology

authors： Jones CM,Prince CA,Williams JS

更新日期：1991-08-01 00:00:00

abstract：:This review of adjunctive therapy with subcutaneous granulocyte-colony stimulating factor (G-CSF) to patients with acute myocardial infarction (AMI) focus on the cardioprotective effects and potential mechanisms of G-CSF and discuss the therapeutic potential of G-CSF. All clinical trials published in peer-reviewed jou...

journal_title：Experimental hematology

authors： Ripa RS,Kastrup J

更新日期：2008-06-01 00:00:00

abstract：:Initially described as an endogenous inhibitor of proteases, the tissue inhibitor of metalloproteinases 1 (TIMP-1) also displays cytokine-like functions. TIMP-1 is a soluble protein whose levels are increased under inflammatory conditions. We recently found that TIMP-1(-/-) mice have decreased bone marrow (BM) cellula...

journal_title：Experimental hematology

authors： Rossi L,Forte D,Migliardi G,Salvestrini V,Buzzi M,Ricciardi MR,Licchetta R,Tafuri A,Bicciato S,Cavo M,Catani L,Lemoli RM,Curti A

更新日期：2015-11-01 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) are somatic mutation-driven hematologic malignancies characterized by bone marrow fibrosis and the accumulation of atypical megakaryocytes with reduced polyploidization in the primary myelofibrosis subtype of the MPNs. Increasing evidence points to a dominant role of abnormal me...

journal_title：Experimental hematology

authors： Yang Q,Crispino JD,Wen QJ

更新日期：2017-04-01 00:00:00

abstract：:The effect of recombinant interleukin 3 (IL-3) on the function of murine resident peritoneal macrophages was investigated. IL-3 enhanced the phagocytosis of Candida pseudotropicalis and Candida albicans and enhanced killing of the former. The enhanced killing is inhibited by scavengers of oxygen radicals, suggesting t...

journal_title：Experimental hematology

authors： Bleiberg I,Kletter Y,Riklis I,Fabian I

更新日期：1989-09-01 00:00:00

abstract：:The statistical distribution of colony counts in the spleen colony assay was determined in C57BL/6 and C3H mice under varying conditions of the assay procedure. Assay mice were given syngeneic bone marrow cells from normal or irradiated donors. The mice were injected intravenously with marrow cells either immediately ...

journal_title：Experimental hematology

authors： Mossman KL

更新日期：1977-11-01 00:00:00

abstract：:Aplastic anemia serum (AAS) contains humoral factors that alter both proliferation and maturation of human megakaryocytes (MK). The ability of AAS to augment MK colony formation (colony-forming unit, CFU-MK) was neutralized by an antiserum against MK colony-stimulating factor (MK-CSF), a glycoprotein isolated from AAS...

journal_title：Experimental hematology

authors： Straneva JE,Briddell RA,McDonald TP,Yang HH,Hoffman R

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:Assays that can evaluate the potential of individual human hematopoietic stem cells (HSC) are still lacking. We previously developed the myeloid-lymphoid initiating cell (ML-IC) assay that enumerates single CD34(+) cells that generate long-term culture-initiating (LTC-IC) and NK-initiating (NK-IC) daughter ce...

journal_title：Experimental hematology

authors： Theunissen K,Verfaillie CM

更新日期：2005-02-01 00:00:00

abstract：:Serum levels of monokines, including macrophage colony-stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha) and IL-1 beta (IL-1 beta), were measured in patients with chronic renal failure in an attempt to clarify the kinetics of these cytokines in the course of renal an...

journal_title：Experimental hematology

authors： Kawano Y,Takaue Y,Motoyoshi K,Minakuchi J,Kawashima S,Saito S,Hirao A,Sato J,Shimizu T,Kuroda Y

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:Our laboratory reported that the angiotensin converting enzyme inhibitor captopril improves erythroid recovery from total body irradiation (TBI) in mice when administered after irradiation. However, captopril administered before TBI attenuates erythroid recovery. Here we investigate captopril and radiation re...

journal_title：Experimental hematology

authors： Barshishat-Kupper M,Mungunsukh O,Tipton AJ,McCart EA,Panganiban RA,Davis TA,Landauer MR,Day RM

更新日期：2011-03-01 00:00:00

abstract：:Antisera from rabbits immunized with murine macrophage colony-stimulating factor (CSF-1) were evaluated for cross-reactivity with human urine CSF-1. One cross-reactive antiserum was used to purify CSF from human urine. The IgG fractions from normal rabbit serum and the anti-CSF serum were bound to cyanogen bromide-act...

journal_title：Experimental hematology

authors： Waheed A,Shadduck RK

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:We previously demonstrated that allogeneic bone marrow transplantation (BMT) after low-dose total lymphoid irradiation (200 cGy) and depletion of donor-reactive cells with cyclophosphamide (Cy) converted recipients to graft-vs-host disease (GVHD)-free chimeras tolerant to donor skin grafts. BMT also generate...

journal_title：Experimental hematology

authors： Prigozhina TB,Gurevitch O,Elkin G,Morecki S,Yakovlev E,Slavin S

更新日期：2003-01-01 00:00:00

abstract：:Umbilical cord blood (CB) is a rich source of hematopoietic stem cells (HSCs) with important applications in allogeneic stem cell transplantation. However, the low numbers of hematopoietic stem and progenitor cells (HSPCs) in banked units remain a major limitation. Protocols developed for HSPC expansion ex vivo or to ...

journal_title：Experimental hematology

authors： Pineault N,Abu-Khader A

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Approximately 60% of all anaplastic large-cell lymphomas (ALCL) contain a specific t(2;5)(p23;q35) chromosomal translocation leading to overexpression of NPM-ALK. As the chimeric tyrosine kinase is involved in tumorigenesis and pathogenesis of ALCL, we were interested to inhibit NPM-ALK expression using an ex...

journal_title：Experimental hematology

authors： Hübinger G,Wehnes E,Xue L,Morris SW,Maurer U

更新日期：2003-03-01 00:00:00

abstract：:Mice deprived of water for three days showed hemoconcentration due to a reduced plasma volume, suppressed erythropoiesis and reduced food intake. All three classes of erythroid progenitor cells in both the bone marrow and spleen of dehydrated mice were markedly suppressed but recovered rapidly upon rehydration. In add...

journal_title：Experimental hematology

authors： Dunn CD,Smith LN

更新日期：1980-05-01 00:00:00

abstract：:We have developed a prospective approach to identify the generation of erythroid cells derived from cultured peripheral blood mononuclear cells (PBMC) by monitoring the expression of the cell surface protein CD48. Unpurified populations of PBMC obtained from the buffy coats of normal volunteers were grown in suspensio...

journal_title：Experimental hematology

authors： Miller JL,Njoroge JM,Gubin AN,Rodgers GP

更新日期：1999-04-01 00:00:00

abstract：:We have found that treatment of B6SUtA1 cells with 0.01% glutaraldehyde transformed them into mechanically resistant spheres, thereby making it possible to use these high interleukin 3 (IL-3) receptor-bearing cells as a solid phase reagent suitable for the large scale purification of murine IL-3 (mIL-3). Using this te...

journal_title：Experimental hematology

authors： Murthy SC,Eaves CJ,Krystal G

更新日期：1989-11-01 00:00:00

abstract：:Fanconi anemia (FA) is a rare recessive disease characterized by progressive bone marrow failure, congenital abnormalities, and increased incidence of cancers. To date, mutations in 22 genes can cause FA or an FA-like phenotype. In China, in addition to clinical information, FA diagnosis primarily relies on genetic se...

journal_title：Experimental hematology

authors： Li N,Ding L,Li B,Wang J,D'Andrea AD,Chen J

更新日期：2018-10-01 00:00:00