Blast colony-forming cells and precursors of colony-forming cells detectable in long-term marrow culture express the same phenotype (CD33- CD34+).

abstract：OBJECTIVE:Although all-trans retinoic acid (ATRA) can bring about complete remission of acute promyelocytic leukemia (APL), the incidence of early recurrence is considerably high. Thus, chemotherapeutic agents, such as anthracycline agents or cytosine arabinoside (AraC), are generally co-administered with ATRA. The the...

journal_title：Experimental hematology

authors： Niitsu N,Higashihara M,Honma Y

更新日期：2002-11-01 00:00:00

abstract：:A right atrial catheter was implanted into 15 patients undergoing bone marrow transplantation as a treatment for acute leukemia. The catheter remained in position for 79 +/- 34 days. No catheter-related septicemia was observed. It appears that this catheter is helpful in supporting bone marrow transplant recipients. ...

journal_title：Experimental hematology

authors： Blume KG,Bross KJ,Riihimaki DU,Schmidt GM

更新日期：1978-08-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated a silencing role for signal transducers and activators of transcription 3 (STAT3) in gamma-globin gene regulation in primary erythroid cells. Recently, GATA-1, a key transcription factor involved in hematopoietic cell development, was shown to directly inhibit STAT3 activity in vivo...

journal_title：Experimental hematology

authors： Yao X,Kodeboyina S,Liu L,Dzandu J,Sangerman J,Ofori-Acquah SF,Pace BS

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:The advantage of recipient hematopoiesis over that of xenogeneic donors poses a fundamental obstacle to the induction of xenograft tolerance through mixed hematopoietic chimerism. Here we explore the role of beta1 integrins in maintenance of human vs porcine hematopoiesis within a human hematopoietic environm...

journal_title：Experimental hematology

authors： Giovino MA,Wang H,Sykes M,Yang YG

更新日期：2005-03-01 00:00:00

abstract：:Deletion of chromosome 13q is believed to be an adverse prognostic marker in patients with multiple myeloma (MM). Interphase fluorescence in situ hybridization (I-FISH) is the method of choice for detection of chromosome 13q deletion (del13q). However, I-FISH has high false-positive rates attributed to a low percentag...

journal_title：Experimental hematology

authors： Hardan I,Rothman R,Gelibter A,Cohen N,Shimoni A,Sokolovsky M,Reichart M,Ishoev G,Amariglio N,Rechavi G,Nagler A,Trakhtenbrot L

更新日期：2004-03-01 00:00:00

abstract：:It is known that inadequate erythropoietin (EPO) production contributes to the pathogenesis of anemia of inflammation, although the exact molecular mechanism is unknown. Aryl hydrocarbon receptor (AhR) may compete with hypoxia-inducible factor 2α (HIF-2α), the master regulator of EPO production, for binding with HIF-1...

journal_title：Experimental hematology

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00

abstract：:We performed the present study to define the in vitro hemopoietic activity of murine recombinant (r) granulocyte colony-stimulating factor (G-CSF) using murine hemopoietic culture systems of normal bone marrow cells, fetal liver cells, and spleen cells of 5-fluorouracil (FU)-treated mice. Recombinant G-CSF supported o...

journal_title：Experimental hematology

authors： Suda T,Suda J,Kajigaya S,Nagata S,Asano S,Saito M,Miura Y

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is expressed by the malignant cells of about 30% of cases of Hodgkin's lymphoma (HL) and is therefore a potential target for immune attack. Given the predominantly immunosuppressive nature of HL infiltrating lymphocytes (HLILs) and the ability ...

journal_title：Experimental hematology

authors： Marshall NA,Culligan DJ,Tighe J,Johnston PW,Barker RN,Vickers MA

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Donor T cells expressing lymph node homing receptors are the foremost initiators of acute graft-vs-host disease (aGVHD), and a high proportion of CD4(+)CCR7(+) T cells in human leukocyte antigen-matched allografts has been shown to confer a high risk of aGVHD without interfering in other outcomes. METHODS:Na...

journal_title：Experimental hematology

authors： Yakoub-Agha I,Saule P,Depil S,Grutzmacher C,Boulanger F,Magro L,Jouet JP,Dessaint JP,Labalette M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Hematopoietic progenitor cells are a promising source for generation of genetically modified dendritic cells. A prerequisite for using these cells in therapeutic approaches is stable vector-mediated transgene expression during and after cell maturation. We investigated the expression of enhanced green fluores...

journal_title：Experimental hematology

authors： Lindemann C,Schilz AJ,Emons B,Baum C,Löw R,Fauser AA,Kuehlcke K,Eckert HG

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether Flk1(+)CD31(-)CD34(-) cells isolated from fetal bone marrow (BM) have characteristics of hemangioblasts, i.e., progenitors of endothelial and hematopoietic cells. MATERIALS AND METHODS:Mononuclear cells from fetal BM were negatively sorted by CD45, GlyA, and CD34 micromagnetic beads, t...

journal_title：Experimental hematology

authors： Guo H,Fang B,Liao L,Zhao Z,Liu J,Chen H,Hsu SH,Cui Q,Zhao RC

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To design a culture method allowing the quantitative and qualitative analysis of terminal erythroid differentiation. METHODS:Primary erythroid progenitors derived either from mouse tissues or from human umbilical cord blood were differentiated using hanging drop cultures and compared to methylcellulose cultu...

journal_title：Experimental hematology

authors： Gutiérrez L,Lindeboom F,Ferreira R,Drissen R,Grosveld F,Whyatt D,Philipsen S

更新日期：2005-10-01 00:00:00

abstract：:Epitopes on the CD34 molecule detected by some CD34 antibodies can be cleaved by a unique glycoprotease from Pasteurella haemolytica, which cleaves only glycoproteins rich in O-linked glycans. A method to isolate CD34+ cells from adult bone marrow was developed subsequently, in which CD34+ cells were isolated in high ...

journal_title：Experimental hematology

authors： Sutherland DR,Yeo EL,Stewart AK,Nayar R,DiGiusto R,Zanjani E,Hoffman R,Murray LJ

更新日期：1996-06-01 00:00:00

abstract：:Four types of colonies can be formed by progenitor cells (CFUc) in double layer agar cultures: eosinophil, granulocyte, macrophage, and mixed granulocyte-macrophage. We have developed a method for in situ staining of intact agar plates with luxol fast blue and acetoorcein employed to differentiate the type of colonies...

journal_title：Experimental hematology

authors： Kirshner JJ,Goldberg J

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:The hematopoietic system is nurtured by a supportive stroma environment allowing maintenance and differentiation of hematopoietic stem cells (HSC). However, only a limited number of these stromal cell clones support hematopoiesis in the absence of cytokine supplementation. So far, only two bone marrow-derived...

journal_title：Experimental hematology

authors： Weisel KC,Gao Y,Shieh JH,Moore MA

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:The cause of delayed hematopoietic reconstitution after umbilical cord blood transplantation (UCBT) remains controversial. We hypothesized that hematopoietic stem/progenitor cells (HS/PCs) from UCB have some defects of the homing-related molecules responsible for their slow engraftment. MATERIALS AND METHODS...

journal_title：Experimental hematology

authors： Zheng Y,Watanabe N,Nagamura-Inoue T,Igura K,Nagayama H,Tojo A,Tanosaki R,Takaue Y,Okamoto S,Takahashi TA

更新日期：2003-12-01 00:00:00

abstract：:Normal human peripheral blood mononuclear cells (MNCs), particularly T lymphocytes (T cells), are a rich source of granulocyte-macrophage colony-stimulating factor (GM-CSF). Glucocorticoids are known to inhibit GM-CSF production in in vitro cultures of a human fibroblast cell line and in normal human blood monocytes a...

journal_title：Experimental hematology

authors： Chikkappa G,Lansing LS,Chu RC,Pasquale D

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Haplotype-mismatched CD34(+) selected allogeneic stem cell transplantation (HASCT) has been described as a therapeutic option for patients with acute myeloid leukemia. The success of this regimen is based mainly on natural killer (NK) cell-mediated antileukemia effects. MATERIALS AND METHODS:We prospectively...

journal_title：Experimental hematology

authors： Schulze A,Schirutschke H,Oelschlägel U,Schmitz M,Füssel M,Wassmuth R,Ehninger G,Bornhäuser M,Platzbecker U

更新日期：2008-04-01 00:00:00

abstract：:The ectopic implantation of mouse marrow to the kidney capsule offers considerable scope as an assay of the hemopoietic microenvironment. Our previous work has shown that whole-body irradiation of the graft recipient prior to implantation results in superior ossicle formation in the kidney of the host. Here we report ...

journal_title：Experimental hematology

authors： Molineux G,Schofield R,Hendry JH,Testa NG

更新日期：1987-07-01 00:00:00

abstract：:Anemia is a frequently observed adverse effect in cancer patients who receive chemotherapy or drugs designed to block specific oncogenic signaling pathways, although the underlying mechanisms are poorly understood. An article first published online (Zhu HH, Luo X, Zhang K, et al. Proc Natl Acad Sci USA 2015;112:13342-...

journal_title：Experimental hematology

authors： Chen WS,Zhu HH,Feng GS

更新日期：2016-05-01 00:00:00

abstract：:Telomeres cap chromosomal ends and are shortened throughout a lifetime. Additional telomere erosion has been documented during conventional chemotherapy or hematopoietic stem cell transplantation. Previous studies of stem cell transplantation reported variable amounts of telomere shortening with inconsistent results r...

journal_title：Experimental hematology

authors： Widmann T,Kneer H,König J,Herrmann M,Pfreundschuh M

更新日期：2008-01-01 00:00:00

abstract：:We have established an in vitro system with which to examine the ability of Abelson murine leukemia virus (A-MuLV) to infect early hemopoietic progenitor cells. Blast cell colonies containing less than 100 cells were shown to contain up to 85% of cells with secondary hemopoietic colony-forming ability. Infection of ce...

journal_title：Experimental hematology

authors： Wong PM,Chung SW,Raefsky E,Eaves CJ,Nienhuis AW

更新日期：1988-01-01 00:00:00

abstract：:The transcription factor SCL is critically required for establishing hematopoiesis and for proper endothelial development, but not for maintenance of hematopoietic stem cells or endothelial cells in the adult. Conflicting data exists regarding the developmental function of SCL, namely, whether it acts as a master regu...

journal_title：Experimental hematology

authors： Ismailoglu I,Yeamans G,Daley GQ,Perlingeiro RC,Kyba M

更新日期：2008-12-01 00:00:00

abstract：:Peripheral blood and bone marrow specimens from patients with polycythemia vera (PV) and chronic myelogenous leukemia (CML) were assayed for erythroid and granulopoietic progenitor cells. All compartments were increased in CML patients in relapse although the ratio of BFU-E to CFU-C numbers remained constant in all CM...

journal_title：Experimental hematology

authors： Eaves AC,Henkelman DH,Eaves CJ

更新日期：1980-01-01 00:00:00

abstract：:Bone marrow endothelial cells are likely to play an important role in the homing of hematopoietic progenitor cells. In view of analyzing the interactions between endothelial cells and hematopoietic progenitor cells, we studied several methods of isolating endothelial cells from human bone marrow, including fluorescenc...

journal_title：Experimental hematology

authors： Schweitzer CM,van der Schoot CE,Dräger AM,van der Valk P,Zevenbergen A,Hooibrink B,Westra AH,Langenhuijsen MM

更新日期：1995-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure. AML is a clinically, morphologically, and genetically heterogeneous disease, and biological differences between adult and childhood AML have been identi...

journal_title：Experimental hematology

authors： Laing AA,Harrison CJ,Gibson BES,Keeshan K

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:T lymphocytes can be activated by soluble factors such as cytokines or through direct cell-cell interactions. Although cytokine receptors are known to signal through STAT family transcription factors, the mechanisms by which other cell-surface molecules, such as CD2, transduce signals is unclear. The goal of ...

journal_title：Experimental hematology

authors： Mahajan S,Gollob JA,Ritz J,Frank DA

更新日期：2001-02-01 00:00:00

abstract：:We have previously reported that granulocyte-macrophage colony-stimulating factor (GM-CSF) given after the administration of 5-fluorouracil (5-FU) results in augmented hematopoietic recovery as evidenced by increased white blood cell and neutrophil counts. Mice receiving GM-CSF following 5-FU administration were obser...

journal_title：Experimental hematology

authors： O'Reilly M,Gamelli RL

更新日期：1990-10-01 00:00:00

abstract：:The effects of chronic exposure to graded hypoxia (inspired PO2 = 146, 90, 78, 73 and 60 torr) on the development of hypoxia-induced hemoglobinemia and the rate of hemoglobin degradation in intact and acutely splenectomized rats were studied. Hemoglobin mass increased with hypoxia over the whole range studied. Hemoglo...

journal_title：Experimental hematology

authors： Ou LC

更新日期：1980-03-01 00:00:00

abstract：:Peritoneal injection of thioglycollate medium (TM) to mice results in a dramatic increase in total number of peritoneal macrophages within 48 to 72 hours. Unlike resident macrophages, a fraction (10 to 20%) of these newly arrived young macrophages, designated as macrophage colony-forming cells (M-CFC), are highly prol...

journal_title：Experimental hematology

authors： Chen B,Chou TH,Sensenbrenner L

更新日期：1993-11-01 00:00:00