Measurement of serum levels of macrophage colony-stimulating factor (M-CSF) in patients with uremia.

Abstract:

:Serum levels of monokines, including macrophage colony-stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha) and IL-1 beta (IL-1 beta), were measured in patients with chronic renal failure in an attempt to clarify the kinetics of these cytokines in the course of renal anemia. M-CSF was the only monokine detectable in the serum from all patients as well as healthy donors, making this cytokine feasible and reliable for serial evaluations. On all occasions, the level of M-CSF in uremic patients was significantly higher than that in healthy donors (29.4 +/- 12.3 vs. 5.5 +/- 1.1 ng/mL). In patients undergoing hemodialysis, the serum level of M-CSF was greater than that in patients undergoing continuous ambulatory peritoneal dialysis or in uremic patients without dialysis therapy. No difference was observed, however, in the levels of IL-1 alpha, IL-1 beta and TNF-alpha levels in these groups. Patients with severe anemia were subsequently treated with 60 to 80 U/kg per week of human recombinant erythropoietin (rhEpo) for 3 months. After this replacement therapy, hemoglobin levels increased with a variable change ranging from 0 to 3.5 g/dL. The pretherapy M-CSF level, however, was found to predict statistically the response to the therapy (p < 0.05). Patients with a lower pretherapy value responded better to rhEpo therapy; those with a higher level showed a minor degree of response. From these results, we postulate that the elevated M-CSF serum level in uremic patients is in part a consequence of the dialysis procedure and that rhEpo therapy is more effective in patients who are under sophisticated dialysis protocol and have a lower M-CSF level.

journal_name

Exp Hematol

journal_title

Experimental hematology

authors

Kawano Y,Takaue Y,Motoyoshi K,Minakuchi J,Kawashima S,Saito S,Hirao A,Sato J,Shimizu T,Kuroda Y

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

220-3

issue

2

eissn

0301-472X

issn

1873-2399

journal_volume

21

pub_type

杂志文章
  • Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.

    abstract::The recent cloning of thrombopoietin (TPO) has allowed us to study its in vivo effects in normal and myelosuppressed mice. Normal Balb/c mice were treated with recombinant human TPO (hTPO) at doses ranging from 1 to 20 kU for 7 days, and complete blood counts (CBCs) and the number of megakaryocytes in the bone marrow ...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Grossmann A,Lenox J,Ren HP,Humes JM,Forstrom JW,Kaushansky K,Sprugel KH

    更新日期:1996-08-01 00:00:00

  • In vivo regulation of hemopoiesis by transforming growth factor beta 1: stimulation of GM-CSF- and M-CSF-dependent murine bone marrow precursors.

    abstract::Injection of mice with either natural bovine bone-derived or human recombinant transforming growth factor beta 1 (TGF-beta 1) resulted in a significant increase of the macrophage and macrophage-granulocyte-forming capacity of their macrophage colony-stimulating factor (M-CSF)- and granulocyte-macrophage colony-stimula...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Bursuker I,Neddermann KM,Petty BA,Schacter B,Spitalny GL,Tepper MA,Pasternak RD

    更新日期:1992-05-01 00:00:00

  • Preparation of human erythropoietin for tissue culture.

    abstract::A simple two-step procedure has been developed for the production of human urinary erythropoietin suitable for tissue culture use. Lyophilized human urinary protein was fractionated by phenyl-Sepharose chromatography, the erythropoietin binding in 2 M lithium chloride and being eluted by an ascending linear gradient t...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Cutler RL,Johnson GR,Nicola NA

    更新日期:1985-09-01 00:00:00

  • Effect of endoglin overexpression during embryoid body development.

    abstract::Increasing evidence points to endoglin (Eng), an accessory receptor for the transforming growth factor-β superfamily commonly associated with the endothelial lineage, as an important regulator of the hematopoietic lineage. We have shown that lack of Eng results in reduced numbers of primitive erythroid colonies as wel...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2012.06.007

    authors: Baik J,Borges L,Magli A,Thatava T,Perlingeiro RC

    更新日期:2012-10-01 00:00:00

  • Progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3 is a potent mobilizer of hematopoietic stem cells.

    abstract:OBJECTIVE:Progenipoietin-1 is an agonist of both the granulocyte colony-stimulating factor and fetal liver tyrosine kinase-3 receptors capable of inducing the proliferation of multiple hematopoietic cell lineages. The potential of progenipoietin-1 to mobilize transplantable hematopoietic stem cells into the peripheral ...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/s0301-472x(01)00675-0

    authors: Fleming WH,Mulcahy JM,McKearn JP,Streeter PR

    更新日期:2001-08-01 00:00:00

  • Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure.

    abstract:OBJECTIVE:To investigate the role of perforin-mediated cell apoptosis in murine models of immune-mediated bone marrow (BM) failure. MATERIALS AND METHODS:We compared C57BL/6J (B6) mice carrying a perforin gene deletion (Prf(-/-)) with wild-type (WT) controls for cellular composition in lymphohematopoietic tissues. Lym...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2008.12.001

    authors: Sarcon AK,Desierto MJ,Zhou W,Visconte V,Gibellini F,Chen J,Young NS

    更新日期:2009-04-01 00:00:00

  • Multilineage dysplasia as assessed by immunophenotype has no impact on clinical-biological features and outcome of NPM1-mutated acute myeloid leukemia.

    abstract::The presence of multilineage dysplasia (MLD) by morphology at diagnosis in acute myeloid leukemia (AML) defines a separate subset in the World Health Organization classification with still-debated prognostic value. A major controversy concerns MLD's role in NPM1-mutated (NPM1⁺) AML, which correlates with good prognosi...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2015.06.003

    authors: Mannelli F,Ponziani V,Bonetti MI,Bencini S,Cutini I,Gianfaldoni G,Scappini B,Pancani F,Rondelli T,Benelli M,Caporale R,Grazia Gelli AM,Peruzzi B,Longo G,Bosi A

    更新日期:2015-10-01 00:00:00

  • Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia.

    abstract::BAALC is identified as a leukemia-associated gene and is highly expressed in CD34-positive hematopoietic stem cells. High BAALC expression is associated with poor prognosis in several types of acute myeloid leukemia. We explored binding partner proteins of BAALC by means of mass spectrometry and analyzed biological pr...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2020.12.003

    authors: Maki H,Yoshimi A,Shimada T,Arai S,Morita K,Kamikubo Y,Ikegawa M,Kurokawa M

    更新日期:2021-01-14 00:00:00

  • Mutagenicity of merocyanine 540-mediated photosensitization.

    abstract::Merocyanine 540 (MC 540) is a photosensitizing dye with antineoplastic and antiviral properties. Because photoexcited MC 540 generates singlet molecular oxygen and possibly other reactive oxygen species there is concern that MC 540-mediated photosensitization may be mutagenic. In this paper, we report on the induction...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: O'Brien JM,Sieber F

    更新日期:1989-02-01 00:00:00

  • Cell biological effects of total body irradiation on growth and differentiation of acute myelogenous leukemia cells compared to normal bone marrow.

    abstract::Radiation therapy is used as total body treatment in preparation of the acute myelogenous leukemia (AML) patient for bone marrow transplantation. Many AML patients will have residual leukemia cells at the time of total body irradiation (TBI). In the present study, the effect of TBI on leukemic myeloid cells was compar...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Greenberger JS,Weichselbaum RR,Botnick LE,Sakakeeny M,Moloney WC

    更新日期:1979-01-01 00:00:00

  • The anti-apoptotic gene Anamorsin is essential for both autonomous and extrinsic regulation of murine fetal liver hematopoiesis.

    abstract::Anamorsin (AM) is an antiapoptotic molecule that confers factor-independent survival on hematopoietic cells. AM-deficient (AM(-/-)) mice are embryonic lethal because of a defect in definitive hematopoiesis; however, the significance of AM in embryonic hematopoiesis remains unknown. This study characterized the hematop...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2014.01.002

    authors: Tanimura A,Shibayama H,Hamanaka Y,Fujita N,Ishibashi T,Sudo T,Yokota T,Ezoe S,Tanaka H,Matsumura I,Oritani K,Kanakura Y

    更新日期:2014-05-01 00:00:00

  • Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model.

    abstract::Graft-versus-host disease (GVHD), mediated by donor-derived alloreactive T cells, is a major cause of nonrelapse mortality in allogeneic hematopoietic stem cell transplantation. Its therapy is not well-defined. We established allele-specific anti-human leukocyte antigen (HLA) monoclonal antibodies (ASHmAbs) that speci...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2014.10.008

    authors: Nakauchi Y,Yamazaki S,Napier SC,Usui J,Ota Y,Takahashi S,Watanabe N,Nakauchi H

    更新日期:2015-02-01 00:00:00

  • Treatment of canine malignancies by 1200 R total body irradiation and autologous marrow grafts.

    abstract::Twenty-five dogs with malignant lymphoma (L) and 18 dogs with solid, nonhematologic tumors (ST) were treated with 1200 R total body irradiation (TBI). Rescue from the otherwise lethal hemopoietic toxicity by infusion of autologous marrow aspirated before TBI was attempted, and survival, response to TBI, and immune rea...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Weiden PL,Storb R,Lerner KG,Kao GF,Graham TC,Thomas ED

    更新日期:1975-04-01 00:00:00

  • Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.

    abstract:OBJECTIVE:To test function of hematopoietic stem cells (HSCs) in vivo in C57BL/6 (B6) and Trp53-deficient (Trp53 null) mice by using two HSC enrichment schemes. MATERIALS AND METHODS:Bone marrow (BM) Lin-CD41-CD48-CD150+ (signaling lymphocyte activation molecules [SLAM]), Lin-CD41-CD48-CD150- (SLAM-) and Lin-Sca1+CD11...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2008.04.012

    authors: Chen J,Ellison FM,Keyvanfar K,Omokaro SO,Desierto MJ,Eckhaus MA,Young NS

    更新日期:2008-10-01 00:00:00

  • The role of fibroblastoid cells and macrophages from mouse bone marrow in the in vitro growth promotion of haemopoietic tumour cells.

    abstract::Adherent cells from mouse bone marrow have been shown to promote the in vitro growth of the AVRij-1 tumour cell line. The experiments presented here suggest that the adherent cells involved in this phenomenon are the progeny of bone marrow derived fibroblastoid colony forming units. The latter were characterized by me...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Zipori D,Bol S

    更新日期:1979-04-01 00:00:00

  • Immunomodulation with donor regulatory T cells armed with Fas-ligand alleviates graft-versus-host disease.

    abstract::Infusion of large numbers of donor regulatory T cells (Tregs) is an effective approach to suppress graft-versus-host disease (GvHD). We have reported previously that enhancing the killing activity of CD25(+) Tregs by decoration with short-lived Fas-ligand (FasL) protein (killer Tregs) is effective in abrogation of aut...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2013.04.016

    authors: Yolcu ES,Kaminitz A,Mizrahi K,Ash S,Yaniv I,Stein J,Shirwan H,Askenasy N

    更新日期:2013-10-01 00:00:00

  • Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells.

    abstract::Differentiation- and lineage-related differences in the expression of two anti-apoptotic molecules, bcl-x and bcl-2, were examined using various human hematopoietic cell lines. Bcl-x was strongly expressed in cell lines with erythroid and megakaryocytic properties (K562, HEL, CMK, and Mo7E), and was moderately express...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Terui Y,Furukawa Y,Kikuchi J,Iwase S,Hatake K,Miura Y

    更新日期:1998-03-01 00:00:00

  • A burst-promoting activity derived from the human bone marrow stromal cell line KM-102 is identical to the granulocyte-macrophage colony-stimulating factor.

    abstract::Recently, several human bone marrow stromal cell lines have established and produced hematopoietic growth factors. One of these factors, a burst-promoting activity (BPA), was purified from 6 liters of serum-free conditioned medium cultured from stromal cell line KM-102, which was stimulated by phorbol myristate acetat...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Kohama T,Handa H,Harigaya K

    更新日期:1988-08-01 00:00:00

  • Analysis of bax protein in sphingosine-induced apoptosis in the human leukemic cell line TF1 and its bcl-2 transfectants.

    abstract::Sphingosine, a sphingolipid breakdown product, has been proposed as an apoptosis-inducing agent. In this study, we examined the effect of sphingosine in bcl-2-overexpressing cells compared with cells that do not express the bcl-2 gene. The human erythroleukemic cell line TF1, which lacks bcl-2 expression, was easily i...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Isogai C,Murate T,Tamiya-Koizumi K,Yoshida S,Ito T,Nagai H,Kinoshita T,Kagami Y,Hotta T,Hamaguchi M,Saito H

    更新日期:1998-11-01 00:00:00

  • Dendritic cells in cancer vaccines.

    abstract::Dendritic cells (DC) are recognized as the most potent antigen-presenting cells with the ability to stimulate naive resting T cells and to initiate primary immune responses. Encouraging results in vaccination studies in animal models and the development of protocols to generate sufficient numbers of human DC for clini...

    journal_title:Experimental hematology

    pub_type: 杂志文章,评审

    doi:10.1016/s0301-472x(01)00730-5

    authors: Brossart P,Wirths S,Brugger W,Kanz L

    更新日期:2001-11-01 00:00:00

  • Hematopoietic stem cell mobilization with G-CSF induces innate inflammation yet suppresses adaptive immune gene expression as revealed by microarray analysis.

    abstract:OBJECTIVE:Granulocyte colony-stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counterproductive. We tested the hypothesis that G-CSF-mobilized peripheral blood stem cell (PBSC) products are immunologically downregulated based on ge...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2007.06.001

    authors: Buzzeo MP,Yang J,Casella G,Reddy V

    更新日期:2007-09-01 00:00:00

  • Long-term persistent lymphopenia in hematopoietic stem cell donors after donation for donor lymphocyte infusion.

    abstract:OBJECTIVES:To analyze the consequences of lymphocyte donations on lymphopoiesis in donors having previously undergone hematopoietic stem cell collection for allogeneic stem cell transplantation. METHODS:Repeated analysis of leukocyte subsets in the peripheral blood of 76 hematopoietic stem cell donors undergoing lymph...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2004.07.021

    authors: Nicolini FE,Wattel E,Michallet AS,Bourgeot JP,Tremisi JP,Hequet O,Michallet M

    更新日期:2004-11-01 00:00:00

  • Allogeneic transplantation of blood stem cells concentrated by density gradients.

    abstract::Discontinuous albumin density gradients were used to physically separate hemopoietic cells from immunocompetent lymphocytes in peripheral blood mononuclear cells of dogs. Transplantation of these stem cell concentrates into lethally irradiated allogeneic recipients restored hemopoiesis in nine of 12 animals. Tolerance...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Gerhartz HH,Nothdurft W,Carbonell F,Fliedner TM

    更新日期:1985-02-01 00:00:00

  • Internal tandem duplication of Flt3 modulates chemotaxis and survival of hematopoietic cells by SDF1alpha but negatively regulates marrow homing in vivo.

    abstract:OBJECTIVE:We have previously shown that Flt3 ligand (FL)/Flt3 signaling regulates hematopoietic cell migration by modulating the SDF1alpha/CXCR4 signaling pathway. Herein, we evaluated whether a functional interaction between SDF1alpha/CXCR4 signaling and internal tandem duplication (ITD) of Flt3 regulates aberrant hem...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2006.04.001

    authors: Fukuda S,Pelus LM

    更新日期:2006-08-01 00:00:00

  • Absence of both subunits of cytochrome b558 in the UM384 cell line relative to the inability to generate superoxide anions.

    abstract::Phagocytic cells are characterized by their ability to generate superoxide anions upon activation by appropriate stimuli. UM384, a myelomonocytic cell line, was shown to be defective in this oxidase activity as measured by nitroblue tetrazolium or cytochrome c reduction. Cytochrome b558, a unique pigment present in ph...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Champelovier P,Laporte F,Verhoeven AJ,Hilarius P,de Klein A,Revol C,Seigneurin D,Kolodie L

    更新日期:1993-07-01 00:00:00

  • Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia.

    abstract::Megakaryocytes have been implicated in the micro-environmental abnormalities associated with fibrosis and hematopoietic failure in the bone marrow (BM) of primary myelofibrosis (PMF) patients, the Philadelphia-negative myeloproliferative neoplasm (MPN) associated with the poorest prognosis. To identify possible therap...

    journal_title:Experimental hematology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.exphem.2019.10.001

    authors: Ishikawa G,Fujiwara N,Hirschfield H,Varricchio L,Hoshida Y,Barosi G,Rosti V,Padilla M,Mazzarini M,Friedman SL,Hoffman R,Migliaccio AR

    更新日期:2019-11-01 00:00:00

  • Prospective identification of erythroid elements in cultured peripheral blood.

    abstract::We have developed a prospective approach to identify the generation of erythroid cells derived from cultured peripheral blood mononuclear cells (PBMC) by monitoring the expression of the cell surface protein CD48. Unpurified populations of PBMC obtained from the buffy coats of normal volunteers were grown in suspensio...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/s0301-472x(98)00086-1

    authors: Miller JL,Njoroge JM,Gubin AN,Rodgers GP

    更新日期:1999-04-01 00:00:00

  • Differential effect of adenosine on DNA synthesis in lymphoid and myeloid cell lines.

    abstract::In this report, the effects of adenosine on the promyelocytic cell line HL-60 and on T-lymphocytic clones are compared. According to previous reports, adenosine induces a dose-dependent inhibition of DNA synthesis in T-lymphocytes. Conversely, adenosine dose-dependently enhances DNA synthesis in HL-60 cells, as docume...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Orrico A,Capecchi PL,De Magistris T,Nuti S,Pasini FL

    更新日期:1991-11-01 00:00:00

  • Antibodies to the beta 1-integrin chain, CD44, or ICAM-3 stimulate adhesion of blast colony-forming cells and may inhibit their growth.

    abstract::Early hematopoietic progenitor cells adhere to bone marrow stromal cells (BMSCs) mainly through VLA-4/VCAM-1 interactions. However, many adhesion molecules are expressed by these cell types. Cell adhesion molecules not only mediate adhesion; some are also capable of triggering cellular signaling events. These signals ...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Oostendorp RA,Spitzer E,Reisbach G,Dörmer P

    更新日期:1997-04-01 00:00:00

  • Animal & computer investigations into the murine erythroid response to chronic hypoxia.

    abstract::During chronic hypoxia, the number of splenic erythroid progenitor cells in mice, particularly CFU-E, increased dramatically but transiently. Since all three classes of erythroid progenitors in the femoral bone marrow were suppressed, a large part of this increase might be attributed to migration of CFU-E and/or their...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Dunn CD,Smith LN,Leonard JI,Andrews RB,Lange RD

    更新日期:1980-01-01 00:00:00