Abstract:
OBJECTIVE:The effect of epicatechin-3-gallate (ECG), a polyphenol that is present in green tea, on doxorubicin (DOX) cytotoxicity in H9C2 cardiomyocytes and its underlying mechanisms were investigated. RESULTS:Pretreatment with ECG (20 and 30 μM) significantly increased DOX-induced apoptosis to 16-18% in H9C2 cardiomyocytes. The Bax/Bcl-2 ratio increased significantly after 1 h pretreatment with ECG. ECG also enhanced the phosphorylation of AMP-activated protein kinase (AMPK) which was induced by DOX in a dose-dependent manner. CONCLUSION:Pretreatment with ECG sensitized H9C2 cells to DOX-mediated apoptosis through modulation of proteins involved in apoptosis and AMPK.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Cai Y,Hong HQ,Zhao L,Cai YP,Qin Ydoi
10.1007/s10529-015-1879-0subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1937-43issue
10eissn
0141-5492issn
1573-6776pii
10.1007/s10529-015-1879-0journal_volume
37pub_type
杂志文章abstract::An endo-beta-(1-->3),(1-->4)-glucanase gene (bglBC1) from Bacillus circulans ATCC21367 was modified by substituting its native promoter with a strong promoter, BJ27X, to increase expression of the gene when cloned into B. subtilis RM125 and B. megaterium ATCC14945. A 771-bp endo-beta-(1-->3),(1-->4)-glucanase open rea...
journal_title:Biotechnology letters
pub_type: 杂志文章
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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abstract::Several alkyl-substituted methoxysilanes were evaluated as potential activity and stability enhancing agents for biomimetic silicification of Rhodosporidium toruloides D-amino acid oxidase (RtDAO). When methyl-substituted silanes along with tetramethoxysilane were used as silicic acid precursors for polyallylamine (PA...
journal_title:Biotechnology letters
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更新日期:2013-03-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Biotechnology letters
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journal_title:Biotechnology letters
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
doi:10.1007/s10529-019-02732-z
更新日期:2019-11-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1023/a:1026038201193
更新日期:2003-10-01 00:00:00
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更新日期:2015-02-01 00:00:00
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journal_title:Biotechnology letters
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更新日期:2005-10-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-011-0568-x
更新日期:2011-07-01 00:00:00
abstract::Ultraviolet-B (UV-B) radiation has significantly negative effect on cell survival rate (P < 0.01) and positive effect on astaxanthin accumulation (P < 0.01) of Haematococcus pluvialis. H. pluvialis accumulated 3.2 mg/g of astaxanthin when being exposed to 5 W/m(2) of UV-B for 60 min prior to 72 h of high light treatme...
journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-010-0371-0
更新日期:2010-12-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-017-2348-8
更新日期:2017-08-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-009-9942-3
更新日期:2009-06-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章
doi:10.1007/s10529-009-0060-z
更新日期:2009-11-01 00:00:00
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journal_title:Biotechnology letters
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00