Abstract:
:A model of radiation-induced bystander effects is presented that explicitly takes into account the transient nature of bystander signal emission post-irradiation, signal lifetime and the non-linear cellular response to the signals. Data are analysed on mutagenesis induced in human lymphoblasts in medium transfer experiments, in which the signal build-up time, medium dilution and the duration of reporter cells' exposure to the medium were varied. The model implies that the cellular release of bystander signals decreases rather slowly, with a characteristic time of about a day, whereas the signal itself decays with a lifetime of about an hour.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Kundrát P,Friedland Wdoi
10.1093/rpd/ncv170subject
Has Abstractpub_date
2015-09-01 00:00:00pages
148-51issue
1-4eissn
0144-8420issn
1742-3406pii
ncv170journal_volume
166pub_type
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