Mechanistic modelling of radiation-induced bystander effects.

Abstract:

:A model of radiation-induced bystander effects is presented that explicitly takes into account the transient nature of bystander signal emission post-irradiation, signal lifetime and the non-linear cellular response to the signals. Data are analysed on mutagenesis induced in human lymphoblasts in medium transfer experiments, in which the signal build-up time, medium dilution and the duration of reporter cells' exposure to the medium were varied. The model implies that the cellular release of bystander signals decreases rather slowly, with a characteristic time of about a day, whereas the signal itself decays with a lifetime of about an hour.

journal_name

Radiat Prot Dosimetry

authors

Kundrát P,Friedland W

doi

10.1093/rpd/ncv170

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

148-51

issue

1-4

eissn

0144-8420

issn

1742-3406

pii

ncv170

journal_volume

166

pub_type

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