Abstract：
:The yield of chromosome aberrations is not only dependent on dose but also on radiation quality, with high linear energy transfer (LET) typically having a greater biological effectiveness per unit dose than those of low-LET radiation. Differences in radiation track structure and cell morphology can also lead to quantitative differences in the spectra of the resulting chromosomal rearrangements, especially at low doses associated with typical human exposures. The development of combinatorial fluorescent labelling techniques (such as mFISH and mBAND) has helped to reveal the complexity of rearrangements, showing increasing complexity of observed rearrangements with increasing LET but has a resolution limited to ∼10 MBp. High-LET particles have not only been shown to produce clustered sites of DNA damage but also produce multiple correlated breaks along its path resulting in DNA fragments smaller than the resolution of these techniques. Additionally, studies have shown that the vast majority of radiation-induced HPRT mutations were also not detectable using fluorescent in situ hybridisation (FISH) techniques, with correlation of breaks along the track being reflected in the complexity of mutations, with intra- and inter-chromosomal insertions, and inversions occurring at the sites of some of the deletions. Therefore, the analysis of visible chromosomal rearrangements observed using current FISH techniques is likely to represent just the tip of the iceberg, considerably underestimating the extent and complexity of radiation induced rearrangements.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Hill MAdoi
10.1093/rpd/ncv151subject
Has Abstractpub_date
2015-09-01 00:00:00pages
295-301issue
1-4eissn
0144-8420issn
1742-3406pii
ncv151journal_volume
166pub_type
杂志文章abstract：:Regional cooperation in radioactive waste management (RWM) in the Asian and Oceanic countries has been successfully developing for more than 20 y. At present, the Asian and Oceanic countries recognise that there are several projects under the regional cooperation, such as the Forum for Nuclear Cooperation in Asia (FNC...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncr124
更新日期：2011-07-01 00:00:00
abstract：:This study characterises and evaluates an Al2O3:C-based optically stimulated luminescent dosemeter (OSLD) system, commercially known as the nanoDot™ dosemeter and the InLight® microStar reader, for personal and in vivo dose measurements in diagnostic radiology. The system characteristics, such as dose linearity, reade...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncz186
更新日期：2019-12-31 00:00:00
abstract：:Monte Carlo simulations of the energy response of a conventionally packaged single metal-oxide field effect transistors (MOSFET) detector were performed with the goal of improving MOSFET energy dependence for personal accident or military dosimetry. The MOSFET detector packaging was optimised. Two different 'drop-in' ...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncq144
更新日期：2010-09-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncy277
更新日期：2019-11-30 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncx256
更新日期：2018-08-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncr435
更新日期：2012-07-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncl100
更新日期：2007-01-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/oxfordjournals.rpd.a006036
更新日期：2002-01-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/nct069
更新日期：2013-09-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncl468
更新日期：2006-01-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncv430
更新日期：2016-06-01 00:00:00
abstract：:To estimate internal doses due to the inhalation of radionuclides produced by the nuclear spallation of the air nuclei in high-energy proton accelerator facilities, the physicochemical properties of radionuclides are very important. Thus, the ratio of aerosol and gases of 38Cl and 39Cl formed by irradiating argon gas-...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncm475
更新日期：2007-01-01 00:00:00
abstract：:The EC (European Council) Directive on radiation protection of patients requires that criteria for acceptability of equipment in diagnostic radiology, nuclear medicine and radiotherapy be established throughout the member states. This study reviews the background to this requirement and to its implementation in practi...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章,评审
doi：10.1093/rpd/ncs295
更新日期：2013-02-01 00:00:00
abstract：:The SCK·CEN has carried out neutron field characterisation campaigns at several nuclear reactors. The main goal of these measurement campaigns was to evaluate the performance of different neutron personal dosemeters. To be able to evaluate the performance of neutron personal dosemeters in terms of Hp(10), knowledge of...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncu193
更新日期：2014-10-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncu075
更新日期：2014-07-01 00:00:00
abstract：:The Schauinsland inter-calibration facility (INTERCAL) has been designed to enable long-term comparison experiments for 20 different dose rate probes from different networks. Two reference probes characterised by the European Radiation Dosimetry WG3 inter-calibration experiments in 2008 and 2009 have been installed at...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncu039
更新日期：2014-08-01 00:00:00
abstract：:CsBr phosphor ceramics doped with different luminescence centres such as In2O3, Eu2O3, EuCl3, SmCl3, TbCl3, GdCl3 or NdCl3 as the candidate for a new optically-stimulable phosphor for medical X-ray imaging sensor were prepared using a conventional ceramic fabrication process. It was found that X-ray-irradiated Eu-dope...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/nci515
更新日期：2006-01-01 00:00:00
abstract：:The NPL simulated reactor neutron field facility provides neutron spectra similar to those found in the environs of UK gas-cooled reactors. Neutrons are generated by irradiating a thick lithium-alloy target with monoenergetic protons between 2.5 and 3.5 MeV (depending on the desired spectrum), and then moderated by a ...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncm018
更新日期：2007-01-01 00:00:00
abstract：:The results of large-scale computed tomography (CT) patient dose surveys from the USA, UK and Germany undertaken during the period 1999-2001 were reviewed. The mean values for volume-weighted CT dose index (CTDI(vol)) and dose length product (DLP) were extracted. For head CT examinations, the reported values for the t...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncs123
更新日期：2013-01-01 00:00:00
abstract：:An assessment of multiple biomarkers from radiation casualties undergoing limited- or full-supportive care including treatment with filgrastim is critical to develop rapid and effective diagnostic triage strategies. The efficacy of filgrastim with full-supportive care was compared with results with limited-supportive ...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncw176
更新日期：2016-12-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncm086
更新日期：2007-01-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/nch168
更新日期：2004-01-01 00:00:00
abstract：:The purpose of this work is to compare different methods for shielding calculation in computed tomography (CT). The BIR-IPEM (British Institute of Radiology and Institute of Physics in Engineering in Medicine) and NCRP (National Council on Radiation Protection) method were used for shielding thickness calculation. Sca...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncr287
更新日期：2011-09-01 00:00:00
abstract：:Relatively high organ doses absorbed by patients in interventional cardiology suggest the opportunity to define these patients as a cohort to be followed forward in time in an epidemiological study of the cancer risks associated with exposure to low-dose ionising radiation. In this paper, the UNSCEAR 2000 Report risk ...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章,评审
doi：10.1093/rpd/ncn036
更新日期：2008-01-01 00:00:00
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journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncaa143
更新日期：2020-11-27 00:00:00
abstract：:Various radionuclides are used in nuclear medicine in different diagnostic and therapeutic procedures. Recently, interest has grown in therapeutic agents for some interesting applications in nuclear medicine. Internal dose models and methods in use for many years are well established, and can give radiation doses to s...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.rpd.a006306
更新日期：2003-01-01 00:00:00
abstract：:Developments in hadron therapy require efforts to improve the accuracy of the dose delivered to a target volume. Here, the determination of the absorbed dose under reference conditions was analysed. Based on the International Atomic Energy Agency TRS-398 code of practice, for hadron beams, the combined standard uncert...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/nct299
更新日期：2014-10-01 00:00:00
abstract：:In order to check developed software tools, it was necessary to compare estimates of statistical characteristics of annual absorbed plutonium internal doses obtained by PANDORA and IMBA software with the same original data. The results were compared from dose calculations of five cases with different initial data on p...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncx085
更新日期：2017-11-01 00:00:00
abstract：:A comparative analysis of radiation doses determined by tooth enamel electron paramagnetic resonance (EPR) spectroscopy and by an acknowledged analytical method is performed for individual doses and for average doses in population of some settlements of the Bryansk region (Russia), which have been contaminated after t...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncu132
更新日期：2014-06-01 00:00:00
abstract：:In March 2011, the Fukushima Daiichi Nuclear Power Plant Accident occurred and a large amount of radionuclides was released. To study its effect, we estimated the internal exposure due to intake of tap water in the early phase after the accident. As the number of measured values of tap water following the accident was...
journal_title：Radiation protection dosimetry
pub_type： 杂志文章
doi：10.1093/rpd/ncx208
更新日期：2018-04-01 00:00:00
